212 research outputs found
METAL IONS AS POTENTIAL REGULATORY FACTORS IN THE BIOSYNTHESIS OF RED HAIR PIGMENTS: A NEW BENZOTHIAZOLE INTERMEDIATE IN THE IRON OR COPPER ASSISTED OXIDATION OF 5-S-CYSTEINYLDOPA
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ATROPOISOMERIC MELANIN INTERMEDIATES BY OXIDATION OF THE MELANOGENIC PRECURSOR 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID UNDER BIOMIMETIC CONDITIONS
No full textFORMATION OF NOVEL TETRAHYDROISOQUINOLINE RETINOIDS BY PICTET-SPENCLER REACTION OF DOPAMINE AND RETINALDEHYDE UNDER CONDITIONS OF RELEVANCE TO BIOLOGICAL ENVIRONMENTS
No full textNUOVI ASPETTI DELLA CHIMICA DI NEUROTRASMETTITORI MONOAMMINICI E DERIVATI CALECOLICI CORRELATI: REAZIONI CON ALDEIDI ED ALTRI SUBSTRATI DI INTERESSE BIOLOGICO
No full textLA SENSIBILITÀ CUTANEA, ESPRESSA IN TERMINI DI MED, COME FUNZIONE DEI LIVELLI DI MELANINA NELLA CUTE E NEI SUOI ANNESSI
No full textSynthesis of 10-Alkylthio- and Arylthio-1,8-Dihydroxy-9-anthrones, A New Class of Anthracene Derivatives of Potential Pharmacological Interest
No full textThe reaction of anthrone I (R = OH) with R1SH [R1 = CH2CH(NH2)CO2H, PhCH2, Bu, Ph) in F3CCO2H gave 51-62% I (R = R1S)
Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update
No full textA review, with 69 refs. No longer dismissed as just a mere curiosity in the family of melanin pigments, neuromelanin is attracting increasing interest as a central constituent of certain populations of dopaminergic neurons in the human substantia nigra, which may hold the key for the understanding of neuron functioning and degeneration in aging and in Parkinson's disease. It is the purpose of this article to provide a concise review of the most significant data on the origin, structure, and functional significance of neuromelanin that accrued over the past few years. It also aims at critically surveying the currently debated views regarding the role of such intriguing pigment in the etiol. and biochem. pathol. of Parkinson's disease
Mechanism of the rearrangement of dopachrome to 5,6-dihydroxyindole
No full textKinetic and isotopic labeling studies provide for the first time evidence that at physiol. pH the rearrangement of dopachrome (I) to 5,6-dihydroxyindole (II) involves abstraction of the proton at position 3 and formation of the intermediate quinone-methide III
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