1,722,782 research outputs found
Lo sci di fondo per persone con disabilità psichica: programma d'intervento ed evidenze valutative
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The dilemma of surgical research between evidences and experience, impact factor and innovation
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The role of laparoscopic distal pancreatectomy in elderly patients
No full textINTRODUCTION: Minimally invasive surgery has gained wide acceptance in many institutions. Complex surgery such as pancreatic resections delayed its diffusion due to high rate postoperative complications and technical aspects, while for pancreaticoduodenctomy the role of a minimally invasive approach is still on debate. Laparoscopic distal pancreatectomy may be considered a safe procedure and a valid alternative in selected cases. The operating time, learning curve and the costs represent major drawbacks for the laparoscopic approach. Elderly patients (>70 years of age) are generally considered to be at higher risk for developing complications after pancreatic surgery due to compromised physiological reserve and presence of multiple comorbidities. Our aim was to make a review about the role of laparoscopic distal pancreatectomy (LDP) in the elderly population. EVIDENCE ACQUISITION: A systematic search of the scientific literature was performed using PubMed, EMBASE, online journals, and the Internet for all publications on LDP and open distal pancreatectomy (ODP) in old age patients.All selected articles were reviewed and analyzed. We found 393 abstract that were reviewed. We considered all type of publications. EVIDENCE SYNTHESIS: Laparoscopic pancreatic resections are considered more difficult due to the retroperitoneal organ location and by the presence of surrounding large vessels and other crucial structures. Therefore, an adequate learning curve is needed. Beyond these remarks, in many institutions, LDP is a standard approach in patients with lesions in the body and tail of the pancreas. The most evident advantage of LDP is the shorter length of stay. Age alone should not be considered as an absolute contraindication for LDP. Obviously, it is still too early to assess oncological outcomes, but the R0 resection rate, the number of harvested lymph nodes, and the overall survival rate are superimposable to ODP. CONCLUSIONS: LDP is safe and feasible if compared to ODP in selected elderly patients with body and tail pancreatic tumors. Less blood loss and shorter hospital stay are the most evident advantages of minimally invasive approach. Randomized controlled trials and high-volume centers prospective studies with long-term outcomes are necessary to consider laparoscopy a standard of care. Minimally invasive robotic surgery may represent an interesting alternative to laparoscopy especially for spleen-preserving procedures
Hidden peculiarities in the potential energy time series of a tripeptide highlighted by a recurrence plot analysis: A molecular dynamics simulation.
No full textA multidimensional approach to the classification of neoclassical combining forms
No full textiThis paper aims to show the usefulness of multidimensional analysis techniques for linguistic classification, and to propose a solution to the much debated categorial status of combining forms providing a classification of such elements based on a detailed analysis of a representative corpus taken from the Italian language. Computational methods for statistical analysis of observed correlations allow for internally compact clusters that are well apart from each other, and also permit the establishment of descriptive variables in consideration of a given data set. This methodology satisfies the requirements of structural stability and flexible adaptability called for in linguistic prototype theory and at the same time it resolves both the problem of an optimal number of classes and predictivity of classification. This analysis gives both a structural description of the studied data set as a whole and a precise allocation of each analyzed item. The analysis, performed on a corpus of 563 Italian combining forms, is based on explicit criteria so that its linguistic interpretation is relatively straightforward. Solid empirical evidence is given to demonstrate that typical combining forms are bound lexemes (stems), consequentially their classification does not require any further linguistic category beyond those of affix and lexeme (the term “combing form” is a convenient descriptive tool for grasping together bound elements used to form morphological complex words not sharing all the characteristics of lexemes or affixes of a particular language). The results support the idea of a more widespread use of cluster analysis in linguistics, both from a methodological and empirical point of view
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