15 research outputs found
Is youth unemployment really the major worry? (AOM)
No full textYouth unemployment is neither the only nor the basic problem of the European labour market. The comparative analysis of unemployment data demonstrates that the unemployment of older people is even more serious. The article proves that the weight of young people in total unemployment has as a tendency been declining in the “inner periphery” of the EU, among them in Central and Eastern European member states (CEECs). The trend is just the opposite in the developed or “core” countries of the Union where youngsters took a higher share in total unemployment in 2012 than 10-12 years ago. In Europe there are millions of young people beyond the active unemployed who do not want to work or think they cannot find a job that fulfils their expectations and refuse to take part in any kind of education or training (NEETs-“Not in Employment, Education or Training”). By estimating the rate of NEETs in the adult population the article claims that the NEETs-phenomenon is not the differentia specifica of the youth. At the end the article details two suggestions for the mitigation of the problem. It concludes that the joblessness in Europe is an old and tendencially worsening problem that cannot be solved by particular policies
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Identifying idiolect in forensic authorship attribution: an n-gram textbite approach
No full textForensic authorship attribution is concerned with identifying authors of disputed or anonymous documents, which are potentially evidential in legal cases, through the analysis of linguistic clues left behind by writers. The forensic linguist “approaches this problem of questioned authorship from the theoretical position that every native speaker has their own distinct and individual version of the language [. . . ], their own idiolect” (Coulthard, 2004: 31). However, given the diXculty in empirically substantiating a theory of idiolect, there is growing concern in the Veld that it remains too abstract to be of practical use (Kredens, 2002; Grant, 2010; Turell, 2010). Stylistic, corpus, and computational approaches to text, however, are able to identify repeated collocational patterns, or n-grams, two to six word chunks of language, similar to the popular notion of soundbites: small segments of no more than a few seconds of speech that journalists are able to recognise as having news value and which characterise the important moments of talk. The soundbite oUers an intriguing parallel for authorship attribution studies, with the following question arising: looking at any set of texts by any author, is it possible to identify ‘n-gram textbites’, small textual segments that characterise that author’s writing, providing DNA-like chunks of identifying material
Forces experienced by instrumented animals depend on lifestyle
No full textAbstractAnimal-attached devices have transformed our understanding of vertebrate ecology. However, to be acceptable, researchers must minimize tag-related harm. The long-standing recommendation that tag masses should not exceed 3% of the animal’s body mass ignores tag forces generated by movement. We used collar-attached accelerometers on four free-ranging carnivores, spanning two orders of magnitude in mass, to reveal that during movement, forces exerted by ‘3%’ tags were generally equivalent to 4-19% of the animals’ masses, with a record of 54% in a hunting cheetah. Controlled studies on domestic dogs revealed how the tag forces are dictated by animal gait and speed but appear largely invariant of body mass. This fundamentally changes how acceptable tag mass limits should be determined, requiring cognizance of animal athleticism.One Sentence SummaryThere can be no universal rule for collar-tag masses as a percentage of carrier mass since tag forces depend on lifestyle.We gratefully acknowledge the access provided by the National Trust and Forest Service NI. 35 We are also grateful to the RSPCA’s Llys Nini Wildlife Centre in Penllergaer, Wales, and to Judy Corbett and Peter Welford at Gwydir Castle in Llanrwst, Wales, for allowing us to work on their property with their dogs. We thank Derek van Heerden and the staff at Harnas Wildlife Foundation in Namibia for their kindness and supporting our work. We thank SANParks and the Department of Wildlife and National Parks, Botswana for allowing our research in the Kgalagadi Transfrontier Park (Permit Number SCAM 1550). We are grateful to Angela Bruns, Sam Ferreira 40 and Danny Govender and Pauli Viljoun for facilitating the research and to the many field staff and volunteers that conducted the fieldwork including Wayne Oppel, Corera Links, Martin van Rooyen and Mads Frost Bertelsen. We are grateful to Fraser Menzies and all the field staff at the Department of Agriculture, Environment and Rural Affairs, DARD. We are also grateful to the Vincent wildlife trust for supporting this research.Funding: This research also contributes to the CAASE project funded by King Abdullah University of Science and Technology (KAUST) under the KAUST Sensor Initiative. This work acknowledges support from the Royal Society/Wolfson Lab refurbishment scheme (RPW). We are grateful for funding from Department of Learning and the Challenge Funding, and access provided by the National Trust and Forest Service NI. The cheetah research was supported by the Royal Society (2009/R3 JP090604) and Natural Environment Research Council (NE/I002030/1) (DMS). The lion work was supported by a Department for Economy Global Challenges Research Fund (DMS) with ethics
50 approval from Queen’s University Belfast (QUB-BS-AREC-18-006), Pretoria University (NAS061-19) and South (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. bioRxiv preprint doi: https://doi.org/10.1101/2020.08.20.258756; this version posted August 21, 2020. The copyright holder for this preprint African National Parks. The badger work was funded by and the Department of Agriculture and Rural Development (DARD) Northern Ireland (currently the Department of Agriculture, Environment and Rural Affairs) through various studentships (DMS, NJM). The Pine marten work was funded by a Department for the Economy studentship to JPT (DMS, NJM); Author contributions: RPW conceived the work and wrote the manuscript with KAR and DMS. RG, SHB, NM, JPT, J.H and DMS collected data, which was analyzed by RPW, KAR, RG and DMS using software developed by MH. All authors provided valuable input to the writing and primary analysis
Exploited Edens: paradise discourse in colonial and postcolonial literature
No full textThis thesis examines the relation between figures of paradise and the ideologies and economies of colonialism, imperialism, and global capitalism, arguing that paradise myth is the product of a value-laden discourse related to profit, labour, and exploitation of resources, both human and environmental, which evolves in response to differing material conditions and discursive agendas. The literature of imperialism and conquest abounds with representations of colonies as potential gold-lands to be mined materially or discursively: from the EI Dorado of the New World and the 'infernal paradise' of Mexico, to the 'Golden Ophir' of Africa and the 'paradise of dharma' of Ceylon. Most postcolonial analyses of paradise discourse have focused exclusively on the Caribbean or the South Pacific, failing to acknowledge the appearance of fantasies of paradise in association with Africa and Asia. Therefore, my thesis not only performs a comparative reading of marginalized paradisal topoi and tropes related to Mexico, Zanzibar, and Ceylon, but also uncovers literature from these regions which has been overlooked in mainstream postcolonial .criticism, mapping the circulations, continuities, and reconfigurations of the paradise myth as it travels across colonie{and continents, empires and ideologies. My analysis of these three regions is divided into six chapters, the first of each section excavating colonial uses ofthe paradise myth and constructing its genealogy for that particular region, the second investigating revisionary uses of the motif by postcolonial writers including Malcolm Lowry, Wilson Harris, Abdulrazak Gurnah, and Romesh Gunesekera. I address imperialist discourse from outside the country in conjunction with discourse from within the independent nation in order to demonstrate how paradise begins as a literal topos motivating European exploration and colonization, develops into an ideological myth justifying imperial praxis and economic exploitation, and [mally becomes a literary motif used by contemporary postcolonial writers to challenge colonial representations and criticize neocolonial conditions
The loss of a child: the long term impact upon the parent-child bond
No full textResearch has been carried out from a psychological perspective, to examine the effects of bereavement in families when they have experienced the loss of a baby, child, teenager or young adult. This has involved interviewing parents in Lebanon, Tanzania and Uganda. The results were then compared to previous research carried out by the author in England (For a M.Phil. in Theology titled, ‘Bereavement in Families who have lost Babies, Children and Teenagers; An Empirical and Theological Study’. Birmingham University , 1995). Using the collective data, the theory of Shadow Grief is investigated in terms of whether it is a genuine condition within bereaved parents, as compared to other grief reactions such as chronic grief, disenfranchised grief or pathological grief.
It was found that the bond between a parent and child was a particularly deep rooted affectionate bond. There are similarities between this bond and Bowlby’s concept of attachment theory. Parents from the English sample showed some signs of maintaining a bond with the deceased many years after the loss. This was seen to a lesser extent in the African context. This requires further research to clarify this effect both in the English culture and cross-culturally, looking at a broader section of communities where child loss had taken place. Grief therapists need to be more aware of the long lasting effects that the loss of a child has upon a parent, especially those who are bereaved of older children
Consanguineous marriage and congenital heart defects: a case-control study in the neonatal period.
No full textThe independent effect of consanguinity on the prevalence of congenital heart defects (CHDs), all and specific types, was investigated in newborns admitted to nine hospitals located in Beirut, Lebanon and members of the National Collaborative Perinatal Neonatal Network (NCPNN). Cases were 173 newborns admitted to the Neonatal Intensive Care Units (NICU) of participating hospitals during the 3-year period from January 1, 2000 to December 31, 2002 and diagnosed during their hospital stay as having one or more CHD. Cases with chromosomal abnormalities were excluded. Cases with more than one CHD were assigned one principal malformation. Controls consisted of a random sample of 865 newborns without a CHD admitted to the NICU during the same period. After controlling for confounders, first cousin consanguinity remained significantly associated with an increased risk of CHD: infants born to first cousin marriages had a 1.8 times higher risk of having a CHD diagnosed at birth compared to those born to unrelated parents (95% CI: 1.1-3.1). In particular, first-cousin marriage was a significant risk factor for ventricular septal defect (VSD), atrial septal defect (ASD), hypoplastic left heart (HLH), and single ventricle (SV). No association was found with d-transposition of the great arteries, coarctation, pulmonary atresia (PA), atrioventricular septal defect (AVSD), and tetralogy of Fallot (TOF). The results of this study suggest a familial factor in the multifactorial etiology of CHDs. Additional epidemiologic and family-based genetic studies are needed to understand the complex cause of CHDs
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No full textPACE TWO
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MEWHKRSHIP APPLICATION
Swincncan lleague of California
Palo Alto Branch
11.111-Mle.y, lOHl
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Memorial rtum-li
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Make Your
4.50 each
A special doll pillow given away to each little girl
that visits our store
STUDY OUR WINDOWS
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Phone 12 222 University Avenue
ISLETON BUTTER
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Going Picnicking?
What a Poor Picnic
A Picnic Would Be
*V.thout A Good
Picnic Dinner!
UK ARK IIKAlHJIAHTEItS a-t>R AIM'ETIZJNG
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Phones 837 and 838
Masonic Temple Bid*?
History and prophecy in the Qumran Pesharim: an examination of the key figures and groups in the Dead Sea Scrolls by way of their prophetic designations.
No full textThe thesis examines the Qumran pesharim and seeks to test the claim that these texts are solely 'historically' based. Instead, it finds that the interpretations are driven by prophetic concerns, founded on and guided by the biblical concept of 'pesher' as dream-interpretation. The study concentrates on the various sobriquets in the pesharim, and is loosely divided into two main parts. Part one examines those designations of groups, including the Kittim, Ephraim and Manasseh, and the Seekers of Smooth Things. Part two, meanwhile, focuses on the interrelationship between the Teacher of Righteousness, the Wicked Priest, and the Man of Falsehood. One of the dominating themes of the thesis is the stress laid on the relationship between the Teacher and the Man of Falsehood, while the thesis also proposes that 'Ephraim' and 'Seekers of Smooth Things' are an offshoot of the Man of Falsehood's original followers. This allows the opposition to this group in 4QpNahum to be properly understood, and suggests a lurk between the Qumran group and the proto-Pharisaic movement. In concluding, the study condemns the suggestion that the 'masking' by sobriquets intentionally conceals these subjects' identity. Rather, such masking links the intended target with prophetic expectations. In short, the thesis finds that although the two are often distinguished in modem scholarship, the correct interpretation of any aspect of the 'historical' pesharim inevitably relies on the understanding of the prophetic term 'pesher' - and vice versa. The thesis does not tackle the issue of the dating of these texts. Rather, it assumes the consensus view that the pesharim were composed during the first century BCE. Occasionally, it will be evident that a text requires a composition before or after a particular date or event, or even that it must postdate another Qumran text, but in general the question has not been an overriding concern
Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting. evidence from the REPOSI register
No full textDiabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie-Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria
Биологическое и клиническое действие абиратерона на антирезорбтивную и анаболическую активность микроокружения костной ткани
No full textПрименение абиратерона ацетата (АА) сопровождается не только значимым увеличением выживаемости пациентов с метастатическим кастрационно-резистентным раком предстательной железы (мКРРПЖ), но также отдалением времени до развития рентгенологического прогрессирования заболевания. Эти преимущества относительно костных метастатических очагов могут быть связаны с непосредственным воздействием на метастатические клетки рака предстательной железы в костях или со специфическими механизмами, направленными на костное микроокружение. Чтобы проверить эти гипотезы, мы прове- ли исследование in vitro, направленное на оценку потенциального действия AA на первичные остеокласты (ОКЛ) / остеобласты (ОБЛ); in vivo оценивали изменения уровней маркеров костного метаболизма, С-концевых телопептидов коллагена 1-го типа (CTX, маркер костной резорбции) и щелочной фосфатазы (ЩФ) у 49 пациентов с мКРРПЖ, получавших AA.Наши результаты показали, что AA оказывает статистически значимое ингибирующее действие на дифференцировку и активность ОКЛ, уменьшая экспрессию ОКЛ-маркерных генов TRAP (тартратрезистентная кислая фосфатаза), образование катепсина К и матриксной металлопротеиназы-9. Кроме того, AA способствовал дифференцировке ОБЛ и отложению костной матрицы, увеличивая экспрессию специфичных для ОБЛ генов RUNX2 (фактор транскрипции-2, содержащий домен Runt), образование ЩФ и остеокальцина. Также мы наблюдали in vivo значимое снижение уровня CTX в сыворотке и повышение уровня ЩФ у пациентов, получавших AA.Эти данные позволяют предполагать новый биологический механизм действия AA, состоящий в прямом анаболическом и антирезорбтивном влиянии на костную ткань.Применение абиратерона ацетата (АА) сопровождается не только значимым увеличением выживаемости пациентов с метастатическим кастрационно-резистентным раком предстательной железы (мКРРПЖ), но также отдалением времени до развития рентгенологического прогрессирования заболевания. Эти преимущества относительно костных метастатических очагов могут быть связаны с непосредственным воздействием на метастатические клетки рака предстательной железы в костях или со специфическими механизмами, направленными на костное микроокружение. Чтобы проверить эти гипотезы, мы провели исследование in vitro, направленное на оценку потенциального действия AA на первичные остеокласты (ОКЛ) / остеобласты (ОБЛ); in vivo оценивали изменения уровней маркеров костного метаболизма, С-концевых телопептидов коллагена 1-го типа (CTX, маркер костной резорбции) и щелочной фосфатазы (ЩФ) у 49 пациентов с мКРРПЖ, получавших AA.Наши результаты показали, что AA оказывает статистически значимое ингибирующее действие на дифференцировку и активность ОКЛ, уменьшая экспрессию ОКЛ-маркерных генов TRAP (тартратрезистентная кислая фосфатаза), образование катепсина К и матриксной металлопротеиназы-9. Кроме того, AA способствовал дифференцировке ОБЛ и отложению костной матрицы, увеличивая экспрессию специфичных для ОБЛ генов RUNX2 (фактор транскрипции-2, содержащий домен Runt), образование ЩФ и остеокальцина. Также мы наблюдали in vivo значимое снижение уровня CTX в сыворотке и повышение уровня ЩФ у пациентов, получавших AA.Эти данные позволяют предполагать новый биологический механизм действия AA, состоящий в прямом анаболическом и антирезорбтивном влиянии на костную ткань
