1,720,995 research outputs found
The prognostic significance of E-cadherin expressioin laryngeal squamous-cell carcinoma: A systematic review
No full textThe aim of this study was to systematically review publications that investigated the prognostic role of E-cadherin immunostaining in patients affected by laryngeal squamous cell carcinoma. An appropriate string was run on PubMed to retrieve articles dealing with this topic. A double cross-check was performed on citations and full-text articles by two authors independently to analyse all manuscripts and perform a comprehensive quality assessment. Among 89 abstracts identified, 13 articles were included. These studies reported on 1,121 patients with histologically confirmed diagnosis of laryngeal squamous cell carcinoma. Overall, there were 10 studies that showed a significant correlation between E-cadherin immunohistochemical expression and at least one of the clinical and histopathological parameters considered by the authors. In particular E-cadherin expression was significantly associated with N stage (five studies), grading (four studies) and disease-free survival/disease-specific survival (six studies). In conclusion, the findings of our review appear similar to the results published by other authors on the putative role of E-cadherin in progression of malignancy. In fact, for laryngeal squamous cell carcinoma it seems that lower levels of E-cadherin correlate with increased tumoural aggressiveness and worse prognosis. Nevertheless, further high-quality prospective studies should be carried out to clarify if E-cadherin expression may be considered as an independent prognostic factor for patients affected by laryngeal cancer
Letter to editor concerning the “Therapeutic strategies in the treatment of Meniere’s disease: the Italian Experience”
No full textIn this letter, we discuss possible alternatives and future perspectives in the therapy of Meniere’s disease. Special attention should be paid to the role of dietary restrictions for glucose in patients with Meniere’s disease, as there is a strong evidence about the presence of insulin receptors in the saccule, the main structure affected by pathological changes due to endolymphatic hydrops; to the possible use of endogenous antisecretory factor administered in specially processed cereals; and to the effects of low-dose intratympanic gentamicin, especially in patients with intractable Meniere’s disease
Effectiveness of intratympanic administration of gentamicin in unilateral menière’s disease
No full textTo the Editor: In a recent issue published by Otology and
Neurotology, Yaz et al. (1) presented an interesting work
to analyze the effectiveness of an intratympanic (IT)
injection of aminoglycosides compared to intratympanic
corticosteroids to control vertigo and protect hearing in
Menie`re’s disease (MD) patients with persistent vertigo
attacks despite medical treatment
Clinical application of cVEMPs and oVEMPs in patients affected by ménière’s disease, vestibular neuritis and benign paroxysmal positional vertigo: A systematic review
Full text linkAttualmente l’applicazione dei potenziali evocati vestibolari miogenici (VEMPs) sta crescendo in molte e differenti patologie. La possibilità di studiare la funzione vestibolare in modo selettivo sia nel sacculo (VEMPs cervicali) sia nell’utricolo (VEMPs oculari) rappresenta una possibilità
recentemente acquisita e l’utilità di tali indagini strumentali sta ancora emergendo e sempre meglio delineandosi. Lo scopo della nostra revisione è
stato quello di definire per quanto possibile le novità nell’applicazione dei VEMPs per la diagnosi e l’approfondimento clinico di tre importanti entità
patologiche: la neurite vestibolare, la malattia di Ménière e la vertigine posizionale benigna. Per realizzare questa revisione sistematica abbiamo
quindi utilizzato tre differenti stringhe di parole chiave su PubMed ricercando in tal modo tutti gli articoli attinenti a queste tematiche. Una doppia
verifica incrociata è stata eseguita da due degli autori prima su tutti i titoli scaturiti dalla ricerca e poi sugli specifici testi degli articoli selezionati
al fine di poterne accertarne la qualità e la effettiva pertinenza. Su un totale di 140 articoli identificati, 26 studi sono stati inclusi nella revisione.
Questi studi comprendevano 1.181 pazienti affetti rispettivamente da neurite vestibolare (296 soggetti), malattia di Ménière (378 soggetti) e vertigine
parossistica benigna (507 soggetti). Per quanto concerne la neurite vestibolare complessivamente l’utilizzo dei cVEMPs e degli oVEMPs è apparso
particolarmente utile nel migliorare l’accuratezza della diagnosi topografica della malattia. Sia per la malattia di Ménière che per la vertigine parossistica posizionale benigna ben 8 studi su 10 che comprendevano anche un gruppo controllo di pazienti sani hanno mostrato come la registrazione dei
VEMPs sia risultata significativamente anormale nei soggetti patologici rispetto a quelli sani. Sebbene ulteriori studi saranno certamente necessari
per meglio definire le soglie di normalità nei valori dei VEMPs per ogni singola entità patologica qui analizzata, al momento possiamo concludere
che la nostra revisione indica la reale utilità della registrazione dei VEMPs. Infatti se integrata alle altre opzioni strumentali disponibili essa sembra
realmente poter garantire un ulteriore innalzamento nella qualità di inquadrare clinicamente queste tre patologie vertiginose.Vestibular evoked myogenic potentials (VEMPs) are increasingly used for different pathologies with new clinical insights. Although the study of otolithic function selectively in both its saccular (cervical VEMPs) and utricular (ocular VEMPs) parts does not represent a recent achievement, the clinical utility of this tool is still emerging. The aim of the present report is to define advances in application of VEMPs in diagnosis and clinical study of vestibular neuritis, Ménière’s disease and benign paroxysmal positional vertigo. To perform a systematic review of the literature, three appropriate strings were run in PubMed to retrieve dedicated articles. A double cross-check was performed on citations and two independent investigators independently reviewed all full-text articles and performed a comprehensive quality assessment. Of 140 articles identified, 26 articles were included, comprising a total of 1,181 patients affected by vestibular neuritis (296 subjects), Ménière’s disease (378 patients) and benign paroxysmal positional vertigo (507 patients). Overall, the use of both cVEMP and oVEMP appeared particularly useful in improving the topographic diagnosis of vestibular neuritis. Most (n = 8) of the studies dedicated to Ménière’s disease and benign paroxysmal positional vertigo (10 overall) also reported significantly abnormal VEMP values compared to healthy controls. Although further reports will be necessary to better define normal threshold levels of VEMPs for each pathology, our review suggests that VEMPs may represent a useful aid in improving the diagnostic accuracy for these three common vestibular pathologies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A novel seated repositioning maneuver for geotropic lateral canal BPPV: efficacy and technique
No full textPurpose: This study introduces and evaluates the sitting lateral canal maneuver (SLCM), a novel seated repositioning technique for treating geotropic lateral canal benign paroxysmal positional vertigo (BPPV). Methods: We conducted a retrospective chart review at the Hospital of Salerno, focusing on 26 patients diagnosed with geotropic LC-BPPV between 2021 and 2022. The SLCM was applied, and its efficacy was assessed based on the resolution of nystagmus and vertigo symptoms. A 95% confidence interval was calculated to estimate the success rate. Results: The SLCM demonstrated a high success rate, with 22 out of 26 patients (approximately 85%, 22/26 patients) showing positive outcomes. The 95% confidence interval for the success rate ranged from approximately 65.02–100%. These findings suggest that SLCM is a potentially effective intervention for LC-BPPV, especially beneficial for patients who find traditional supine or lateral maneuvers uncomfortable. Conclusion: The SLCM represents a promising alternative to traditional BPPV maneuvers, especially for patients requiring a seated approach. While the initial results are encouraging, further research with larger sample sizes and longer follow-up periods is needed to validate its efficacy and explore its full potential in the management of LC-BPPV. Level of evidence: This study represents a Level IV source of evidence, as defined by the evidence-based practice guidelines. It is a retrospective chart review that involves a moderate cohort of patients diagnosed with geotropic horizontal positional nystagmus consistent with lateral canal benign paroxysmal positional vertigo (LC-BPPV). While the study provides valuable insights into the efficacy of the sitting lateral canal maneuver (SLCM) and contributes to the existing literature on BPPV management, it is important to note the inherent limitations associated with this level of evidence
Inner ear disorders in scuba divers: a review
Full text linkSelf-Contained Underwater Breathing Apparatus (SCUBA) diving is a popular sport. However, improper diving may injure different organs. The majority of dive-related disorders concern otolaryngology, and may include hearing loss, tinnitus, aural fullness, disequilibrium, and vertigo. Three main inner ear pathological conditions can occur underwater: inner ear barotrauma (IEB), inner ear decompression sickness (IEDS), and alternobaric vertigo (AV). IEB results from inappropriate equalization of middle ear pressure and consequent inner ear injury produced by pressure changes within the middle ear; IEDS is characterized by the formation of gas bubbles within the vessels of the inner ear during rapid ascent; AV typically develops while ascending or performing the Valsalva maneuver and can follow asymmetrical equalization of middle ear pressure transmitted via the oval and round window membranes. The clinical pictures of these pathological conditions are partly superimposable, even if they have specific peculiarities. Before starting SCUBA diving, a fit-to-dive assessment is recommended. It should include an otolaryngologic examination with audiological assessment to evaluate nasal, middle ear, and tubal patency and to minimize the risk of IEB, IEDS, and AV. It is of utmost importance to identify individual risk factors and predisposing pathological conditions that favor inner ear injury before diving, to pre-vent acute events and preserve auditory and vestibular functions in SCUBA divers. This review aims to provide an overview of the pathological conditions characterized by inner ear injury in SCUBA divers, discussing their pathogenetic mechanisms, diagnostic work-up, and prevention
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