2,393 research outputs found
Tauveron C. (coord.) : Lire la littérature à l'école. Pourquoi et comment conduire cet apprentissage spécifique de la GS au CM. ?, 2002
No full textTurco Gilbert. Tauveron C. (coord.) : Lire la littérature à l'école. Pourquoi et comment conduire cet apprentissage spécifique de la GS au CM. ?, 2002. In: Repères, recherches en didactique du français langue maternelle, n°24-25, 2001. Enseigner l'oral, sous la direction de Claudine Garcia-Debanc et Isabelle Delcambre. pp. 284-289
Observatoire national de la lecture ; J. Morais et G. Robillart (Dir.) (1998) : Apprendre à lire au cycle des apprentissages fondamentaux (GS, CP, CE1) Analyses, réflexions, propositions
No full textDucancel Gilbert. Observatoire national de la lecture ; J. Morais et G. Robillart (Dir.) (1998) : Apprendre à lire au cycle des apprentissages fondamentaux (GS, CP, CE1) Analyses, réflexions, propositions. In: Repères, recherches en didactique du français langue maternelle, n°18, 1998. À la conquête de l'écrit, sous la direction de Mireille Brigaudiot et Roland Goigoux. pp. 224-227
Observatoire national de la lecture ; J. Morais et G. Robillart (Dir.) (1998) : Apprendre à lire au cycle des apprentissages fondamentaux (GS, CP, CE1) Analyses, réflexions, propositions
No full textDucancel Gilbert. Observatoire national de la lecture ; J. Morais et G. Robillart (Dir.) (1998) : Apprendre à lire au cycle des apprentissages fondamentaux (GS, CP, CE1) Analyses, réflexions, propositions. In: Repères, recherches en didactique du français langue maternelle, n°18, 1998. À la conquête de l'écrit, sous la direction de Mireille Brigaudiot et Roland Goigoux. pp. 224-227
Photograph - Scholarships - Melbourne. Belinda Franjic and Owain Emshe (both National ’97) with Professor Alan Gilbert and Rae Pierce (Principal of Penleigh & Essendon GS). 28 Feb 1997
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/288117Scholarships - Melbourne. Belinda Franjic and Owain Emshe (both National ’97) with Professor Alan Gilbert and Rae Pierce (Principal of Penleigh & Essendon GS). 28 Feb 1997298585
Item: [2003.0003.05096] "Photograph - Scholarships - Melbourne. Belinda Franjic and Owain Emshe (both National ’97) with Professor Alan Gilbert and Rae Pierce (Principal of Penleigh & Essendon GS). 28 Feb 1997
GILBERT SYNDROME: GENETIC FACTORS AND DIAGNOSTIC APPROACHES
No full textGilbert syndrome (GS) is an inherited disorder of bilirubin metabolism characterized by unconjugated hyperbilirubinemia. The condition is associated with a mutation in the promoter region of the UGT1A1 gene, which encodes the enzyme uridine diphosphate-glucuronosyltransferase 1A1. Although often asymptomatic, accurate diagnosis of GS is important to prevent misdiagnosis, unnecessary investigations, and overtreatment
Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America.
No full textThe genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies. The analyses show 85 predicted open reading frames (ORFs), conservation with sequenced HHV-6A reference strain U1102, and closest identity to the recently determined GS strain, despite different geographic origins (United States and Gambia)
Gilbert sendromlu hastalarda aort sertliğinin değerlendirilmesi: Artmış bilirubin düzeyinin koruyucu etkisi
No full textAmaç: Gilbert sendromu (GS) indirekt bilirubin artışıyla karakterize otozomal resesif bir hastalıktır. Gilbert sendromunda aterosklerotik kalp hastalığı insidansı azalmıştır. Biz bu çalışmada GS’nin varlığı ve nabız dalga hızı (NDH) arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Bu çalışmaya hastanemiz iç hastalıkları kliniğine başvuran 32 kadın (yaş: 27.12±7.27) ve 26 erkek (yaş: 26.63±5.84) olmak üzere toplam 58 GS’li hasta alındı. Kontrol grubu olarak benzer yaş grubunda olan 35 kadın (yaş: 27.33±8.06, p=0.716) ve 23 erkek (yaş: 27.38±6.91, p=0.923) olmak üzere 58 sağlıklı katılımcı çalışmaya dahil edildi. Her iki grubun NDH’si sağ karotis ve femoral arterlerden ölçüldü. Bulgular: Gilbert sendromu grubunun yaş ortalaması 26.03±8.22 yıl ve sağlıklı grubun yaş ortalaması 26.60±5.84 yıl idi. Gilbert sendromu grubunun diyastolik kan basıncı (67.76±8.59 mmHg) ve NDH’si (5.63±1.12 m/s) kontrol grubundan (71.72±7.28 mmHg, p=0.008; 6.18±1.22 m/s, p=0.014) anlamlı olarak daha düşüktü. Gilbert sendromu gru- bunun yüksek yoğunluklu lipoprotein düzeyi (1.4±0.3 mmol/L) kontrol grubundan (1.2±0.3 mmol/L mmol/L, p=0.029) anlamlı şekilde daha yüksekti. Sonuç: Biz bu çalışmada, GS’li hastaların NDH değerlerini sigara içmeyen, yaş uyumlu sağlıklı bireylerden düşük bulduk.Objective: Gilbert’s syndrome (GS) is an autosomal reces- sive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS. Methods: The study included 58 GS patients (32 females, age; 27.12±7.27 years, 26 males, age; 26.63±5.84 years) admitted to the internal medicine clinic of the hospital. The control group included 58 healthy individuals (35 females [27.33±8.06 years old, p=0.716] and 23 males [27.38±6.91 years old, p=0.923]). PWV of both groups was measured from the right carotid and femoral arteries. Results: Mean age of the GS group was 26.03±8.22 years, while that of the healthy group was 26.60±5.84 years. The GS group’s diastolic blood pressure and PWV were significantly lower than those of the control group: 67.76±8.59 mmHg vs 71.72±7.28 mmHg; p=0.008, and 5.63±1.12 m/s vs 6.18±1.22 m/s; p=0.014 respectively. The GS group’s high density lipo- protein (HDL) level was significantly higher than that of the control group: 1.4±0.3 mmol/L vs 1.2±0.3 mmol/L, p=0.029. Conclusion: This study found PWV among GS patients to be lower than that among non-smoking and aged-matched healthy controls
Acute pancreatitis and severe hyperbilirubinemia as initial presentation of Gilbert syndrome
No full textGilbert syndrome (GS) is benign, often familial condition characterized by recurrent but asymptomatic mild unconjugated hyperbilirubinemia in the absence of hemolysis or underlying liver disease. The coexistence of GS with other more clinically significant conditions could interfere with their diagnoses. The genetic variation described as GS may affect drug glucuronidation and could potentially precipitate. Gallstones are the commonest ailment affecting the hepato-biliary system. Associated jaundice is usually direct, commonly due to biliary obstructive lesions. Unconjugated hyperbilirubinemia with cholelithiasis is commonly seen with hemolytic disease. In the absence of hemolysis or systemic causes, congenital causes prevail, commonest of which is Gilbert’ Syndrome. Here we report a case of 21-year old male who presented to our hospital with complaint of pain abdomen and was diagnosed as gall stone induced pancreatitis which was further diagnosed as GS after genetic testing for UGT1A1 gene polymorphism
SÍNDROME DE GILBERT E SUA RELAÇÃO COM DOENÇAS CARDIOVASCULARES: GILBERT\u27S SYNDROME AND ITS RELATIONSHIP WITH CARDIOVASCULAR DISEASES
No full textRESUMO
Introdução: A Síndrome de Gilbert (SG), caracterizada pelo aumento moderado de bilirrubina não conjugada (BNC), pode coexistir com outras condições mais clinicamente significativas e interferir em seus parâmetros clínicos e diagnósticos. Objetivo: Identificar na literatura a relação da Síndrome de Gilbert com doenças cardiovasculares (DCV), além de trazer uma visão geral sobre a associação da bilirrubina ao metabolismo lipídico alterado e a outros parâmetros hematológicos. Método: Trata-se de uma revisão integrativa, utilizando como fontes de pesquisa a SciELO, LILACS, PubMed e periódicos da CAPES. Artigos de revisão, relatos de casos, teses, dissertações e monografias foram excluídos. Os descritores “Doença de Gilbert”, “doenças cardiovasculares”, “hiperbilirrubinemia” e “testes hematológicos” foram utilizados no idioma inglês e seus correspondentes em português, empregando o operador booleano “AND”. Resultados: A busca nas bases de dados resultou na seleção de 11 artigos, publicados entre 2011 e 2017, que permitiram especular evidências sobre a relação existente entre a hiperbilirrubinemia leve na SG com as DCV. Níveis de estresse oxidativo reduzido, atenuação de ativação plaquetária e de processos pró-inflamatórios, hipocolesterolemia e outros achados foram associados à concentração de BNC. Conclusão: Os estudos evidenciaram possíveis mecanismos que podem contribuir para a redução do risco de DCV em indivíduos com SG, principalmente na incidência de arritmias cardíacas, doença arterial coronariana e cardiopatias ateroscleróticas.
Palavras-chave: Doença de Gilbert; UDP-glucuronosiltransferase; Hiperbilirrubinemia; Doenças Cardiovasculares; Testes Hematológicos.
ABSTRACT
Introduction: Gilbert\u27s Syndrome (GS), characterized by a moderate increase in unconjugated bilirubin (UCB), can coexist with other more clinically significant conditions and interfere with its clinical and diagnostic parameters. Objective: To identify in the literature the relationship between Gilbert\u27s Syndrome and cardiovascular diseases (CVD), in addition to providing an overview of the association of bilirubin with altered lipid metabolism and other hematological parameters. Method: This is an integrative review, using SciELO, LILACS, PubMed and CAPES journals as research sources. Review articles, case reports, theses, dissertations and monographs were excluded. The descriptors "Gilbert Disease", "cardiovascular diseases", "hyperbilirubinemia" and "hematologic tests" were used in english and their correspondents in portuguese, using the boolean operator "AND". Results: The search in the databases resulted in the selection of 11 articles, published between 2011 and 2017, which allowed speculating evidence on the relationship between mild hyperbilirubinemia in GS and CVD. Levels of reduced oxidative stress, attenuation of platelet activation and pro-inflammatory processes, hypocholesterolemia and other findings were associated with UCB concentration. Conclusion: The studies showed possible mechanisms that can contribute to the reduction of CVD risk in individuals with GS, mainly in the incidence of cardiac arrhythmias, coronary artery disease and atherosclerotic heart diseases.
Keywords: Gilbert Disease; UDP-glucuronosyltransferase; Hyperbilirubinemia; Cardiovascular Diseases; Hematologic Test
EBUS-GS and VBN for GGO lesions
No full textBackground: Endobronchial ultrasonography with guide sheath (EBUS-GS) could be useful for diagnosing ground-glass opacity (GGO) predominant-type lesions in the peripheral lung. Furthermore, several studies have reported that transbronchial biopsy using EBUS-GS and virtual bronchoscopic navigation (VBN) was safe and effective for diagnosing small peripheral lung lesions. Our objectives were to diagnose solitary peripheral GGO predominant-type lesions by transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance, and to evaluate the clinical factors associated with diagnostic yield. Methods: The medical records of 169 patients with GGO predominant-type lesions who underwent transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance were retrospectively reviewed. Results: Endobronchial ultrasonography images could be obtained for 156 (92%) of 169 GGO predominant-type lesions, and 116 (69%) were successfully diagnosed by this method (20 of 31 pure GGO lesions [65%]; 96 of 138 mixed GGO predominant-type lesions [70%]). The mean size of diagnosed lesions was significantly larger than that of nondiagnosed lesions (22 mm versus 18 mm, p < 0.01). Regarding diagnostic yield based on computed tomography sign, cases with presence of a bronchus leading directly to a lesion had significantly higher diagnostic yield than the other lesions (p < 0.01). Conclusions: The addition of VBN to EBUS-GS could be useful in clinical practice for diagnosing GGO predominant-type lesions in the peripheral lung
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