76 research outputs found
Vertebral body stent augmentation to reconstruct the anterior column in neoplastic extreme osteolysis.
No full textBACKGROUND
Extensive lytic lesions of the vertebral body (VB) increase risk of fracture and instability and require stabilization of the anterior column. Vertebral augmentation is an accepted treatment option, but when osteolysis has extensively destroyed the VB cortical boundaries (a condition herein defined as 'extreme osteolysis'), the risk of cement leakage and/or insufficient filling is high. Vertebral body stents (VBSs) might allow partial restoration of VB height, cement containment, and reinforcement, but their use in extreme osteolysis has not been investigated.
OBJECTIVE
To assess retrospectively the feasibility and safety of VBS augmentation in patients with 'extreme osteolysis' of the VB.
METHODS
We retrospectively analyzed 41 treated vertebrae (from T1 to L5). VB reconstruction was assessed on postprocedure CT images and rated on a qualitative 4-point scale (poor-fair-good-excellent). Clinical and radiological follow-up was performed at 1 month and thereafter at intervals in accordance with oncological protocols.
RESULTS
VBS augmentation was performed at 12 lumbar and 29 thoracic levels, with bilateral VBS in 23/41. VB reconstruction was judged satisfactory (good or excellent) in 37/41 (90%) of levels. Bilateral VBS received higher scores than unilateral (p=0.057, Pearson's X). We observed no periprocedural complications. Cement leaks (epidural or foraminal) occurred at 5/41 levels (12.2%) without clinical consequences. Follow-up data were available for 27/29 patients, extending beyond 6 months for 20 patients (7-28 months, mean 15.3 months). VBS implant stability was observed in 40/41 cases (97.5%).
CONCLUSIONS
Our results support the use of VBS as a minimally invasive, safe and effective option for reconstructing the anterior column in prominent VB osteolysis
The Relationship Between Sensory Processing and Academic Readiness in Preschool-Age Children of High-Need Families
No full textAbstract
Date Presented 3/30/2017
This session reviews study results describing the relationships among sensory processing, child behavior, academic readiness, and caregiver characteristics in preschool children from high-risk families. Results of the study and implications for occupational therapy practice are presented.
Primary Author and Speaker: Jeanne Zobel-Lachiusa
Contributing Authors: Kathryn Wiezbicki-Stevens, Dawn DiStefano</jats:p
Erratum: Excisional hemorrhoidectomy versus dearterialization with mucopexy for the treatment of grade III hemorrhoidal disease: the EMODART3 multicenter study, (vol 66, pg e1254-e1263, 2023)
No full textIn the article “Excisional Hemorrhoidectomy Versus Dearterialization With Mucopexy for the Treatment of Grade III Hemorrhoidal Disease: The EMODART3 Multicenter Study,”1 which appeared in Volume 66, Issue 12, pages e1259-e1263 of Disease of the Colon & Rectum, the first name of one of the collaborators was incorrectly listed. The correct name is Giuseppe Giuliani and is corrected below. EMODART3 Study Group: Antonio Giuliani, Lucia Romano, Stefano Necozione, Vincenza Cofini, Giada Di Donato, Mario Schietroma, Francesco Carlei, Andrea Nervini, Gaetano Gallo, Renato Pietroletti, Giuseppe Giuliani, Antonella Veglia, Nicola Antonacci, Letizia Santandrea, Giacomo Sermonesi, Francesca Babic, Giulia Ceschiutti, Giuseppe Sica, Giulia Bagaglini, Andrea Divizia, Vittoria Bellato, Noureen Fazili, Janindra Warusavitarne, Luigi Boccia, Annalisa Pascariello, Andrea Bondurri, Claudio Guerci, Anna Maffioli, Luca Domenico Bonomo, Giovanni Distefano, Alberto Jannaci, Alberto Buonanno, Luca Cardinali, Irene Marziali, Gianfranco Cocorullo, Federico Cozzani, Mario Giuffrida, Matteo Rossini, Paola De Nardi, Andrea Marco Tamburini, Claudio Francesco Feo, Chiara Ninniri, Cristina Folliero, Davide Gattesco, Marta Mozzon, Marco La Torre, Filippo La Torre, Cristina De Padua, Immacolata Iannone, Antonio Langone, Raffaele Galleano, Omar Ghazouani, Giorgio Lisi, Michela Campanelli, Umberto Passaro, Pierluigi Lobascio, Rita Laforgia, Massimo Ottonello, Roberto Perinotti, Mauro Pozzo, Davide Piccolo, Patrizio Capelli, Gerardo Palmieri, Nicoletta Sveva Pipitone Federico, Marcella Rinaldi, Gennaro Martines, Arcangelo Picciariello, Francesco Selvaggi, Francesco Maria Romano, Lucio Selvaggi, Nicola Tricomi, Leonardo Comparetto, Luigi Velci, Edoardo Virgilio, Alfredo Annicchiarico, Carlo Salvemini, Cinzia Tanda, Paolo Federico Corona, Gianfranco Porc
Kinetic Trapping of an Out‐of‐Equilibrium Dynamic Library of Imines by Changing Solvent
No full textA well-behaved dynamic library composed of two imines and corresponding amines was subjected to the action of an activated carboxylic acid (ACA), whose decarboxylation is known to be base promoted, in different solvents, namely CD2Cl2, CD3CN, and mixtures of them. Two non-equilibrium systems are consequently obtained: i) a dissipative (CD2Cl2) and ii) an out-of-equilibrium (CD3CN) dynamic library whose composition goes back to equilibrium after a given time. In the former case, the library is fully coupled with the decarboxylation of the ACA, while in the latter, an energy ratchet operates. In the mixed solvents, the library exhibits a mediated behavior. Interestingly, in the presence of an excess of added ACA, the different behavior of the imine library in the two solvents is expected to manifest only when the excess acid is consumed.When an Activated Carboxylic Acid (ACA) is employed to perturb a dynamic library of imines, the nature of the solvent has a crucial role in defining the non-equilibrium state of such library. A dissipative dynamic library in CD2Cl2, fully coupled with the decarboxylation of the ACA, or a kinetically trapped out-of-equilibrium dynamic library in CD3CN can be generated. imag
Spectrum of skeletal abnormalities in a complex malformation syndrome with "cutis tricolor" (Ruggieri-Happle syndrome)
No full textBackground: The term cutis tricolor describes the combination of congenital hyper- and hypopigmented skin lesions in close proximity to each other in a background of normal complexion. This phenomenon has been reported: (i) as a purely cutaneous trait; (ii) as a part of a complex malformation syndrome (Ruggieri-Happle syndrome - RHS); (iii) as a distinct type [cutis tricolor parvimaculata]; (iv) in association with other (e.g. vascular) skin disturbances. Objectives: To delineate the spectrum of skeletal defects in cutis tricolor. Methods: Retrospective and prospective analysis of skeletal surveys in 14 subjects (eight men; six women; aged 2-28 years) with cutis tricolor [4 purely cutaneous trait; 10 syndromic (RHS)]. Results: Bone abnormalities were recorded in 71.4% (10/14) of patients [100% (10/10) of cases with (other-than-skeletal) extra-cutaneous manifestations vs. null (0/4) in cases with purely cutaneous traits] and included overall small skull (n = 6); prognathism (n = 6); 'J'-shaped pituitary fossa (n = 1); absence of atlas posterior arch (n = 3); frontal bossing (n = 6); scoliosis (n = 9) with kyphosis (n = 6) and/or lordosis (n = 6); vertebral (n = 9) and ribs (n = 4) defects. Negative ZFHX1B gene analyses excluded overlaps with Mowat-Wilson syndrome. Conclusions: Cutis tricolor may be a marker of underlying skeletal involvement particularly in subjects with a complex syndromic (RHS) phenotype. © 2010 The Author(s)/Acta Pædiatrica © 2010 Foundation Acta Pædiatrica
Building the future. Zero energy school : Cairate
No full textLAUREA MAGISTRALENel contesto di un piccolo comune di provincia, Cairate, abitato da
meno di 8.000 cittadini si inserisce la progettazione di un Nuovo Polo
Scolastico da 600 studenti, che permetterà la dismissione di obsolete
e tecnologicamente inadeguate strutture presenti nella zona.
Abbiamo portato avanti il lavoro in due macro-fasi, la prima di approfondimento
sulla situazione del sistema scolastico Italiano e dell’edilizia
scolastica Italiana, messi a paragone con quanto è accaduto in
Europa e nel Mondo nel corso degli ultimi cent’anni, e la seconda di
progettazione, tramite l’utilizzo di software BIM e di analisi veicolare,
che ci ha permesso di controllare tutto il processo progettuale, non
solo dal punto di vista compositivo, ma anche energetico, funzionaleorganizzativo
e riguardante i flussi veicolari che il progetto avrebbe
causato nella viabilità di quartiere.
Il risultato mostra un manufatto scolastico energicamente autosufficiente,
caratterizzato da elevati standard tecnologici, dotato di ambienti
flessibili che rispondono alle esigenze attuali senza inficiare future
e mutate richieste; l’analisi avente oggetto i flussi veicolari inoltre
ci ha mostrato come l’impatto del progetto sulla viabilità di quartiere
potesse essere critico, abbiamo quindi proposto una nuova viabilità
che possa sfruttare appieno le infrastrutture presenti senza caricare la
zona di nuove.In the context of a small town of Varese district, Cairate, in which live
less than 8,000 citizens, there is the project of a new School for 600
students, which will allow the disposal of obsolete and technologically
inadequate artifacts in the area.
We keep on the work into two main phases, the first deepening the
situation of the Italian school system and school buildings, put in
comparison with what happened in Europe and in the World over the
last hundred years, and the second on the design, through the use of
BIM software and vehicular analysis, which allowed us to control the
entire design process, not only from the point of view of composition,
but also energetic, functional and organizational concerning traffic
flow that the project would have caused to the viability of the district.
The result shows an artifact school energetically self-sufficient, characterized
by high technological standards, with flexible room that
meet the needs of the present without compromising future and
changing demands; vehicular and flows analysis also showed us how
the project’s impact on the viability of the district could be critical, we
have proposed a new way that can take full advantage of the existing
facilities without loading new road
HIV in Japan: Epidemiologic puzzles and ethnographic explanations
No full textAbstractJapan is widely perceived to have a low level of HIV occurrence; however, its HIV epidemics also have been the subject of considerable misunderstanding globally. I used a ground truthing conceptual framework to meet two aims: first, to determine how accurately official surveillance data represented Japan's two largest epidemics (urban Kansai and Tokyo) as understood and experienced on the ground; and second, to identify explanations for why the HIV epidemics were unfolding as officially reported. I used primarily ethnographic methods while drawing upon epidemiology, and compared government surveillance data to observations at community and institutional sites (459 pages of field notes; 175 persons observed), qualitative interviews with stakeholders in local HIV epidemics (n = 32), and document research (n = 116). This revealed seven epidemiologic puzzles involving officially reported trends and conspicuously missing information. Ethnographically grounded explanations are presented for each. These included factors driving the epidemics, which ranged from waning government and public attention to HIV, to gaps in sex education and disruptive leadership changes in public institutions approximately every two years. Factors constraining the epidemics also contributed to explanations. These ranged from subsidized medical treatment for most people living with HIV, to strong partnerships between government and a well-developed, non-governmental sector of HIV interventionists, and protective norms and built environments in the sex industry. Local and regional HIV epidemics were experienced and understood as worse than government reports indicated, and ground-level data often contradicted official knowledge. Results thus call into question epidemiologic trends, including recent stabilization of the national epidemic, and suggest the need for revisions to the surveillance system and strategies that address factors driving and constraining the epidemics. Based upon its utility in the current study, ground truthing has value as a conceptual framework for research and shows promise for future theoretical development
The Lebanese crisis of summer 2006 In terms of jus contra bellum
No full textAs the title denotes, the present article focusses on the application of ius contra bellum rules ; in other word, the author will examine States\u27 and non-State actors\u27 conducts during summer 2006 events through the sole spectrum of rules relating to the right to the use of force in intern national relations, formerly known as the right to wage war. Thus, this article will not deal with the body of rules pertaining to the conduct of belligerents during armed conflict, i.e. the ius in bellum. Therefore, special, yet not exclusive emphasis will be put on Israel\u27s title to resort to armed force in order to guarantee its allegedly infringed rights. To this effect, the author will review different legal rules (and set of rules) which could validate Israel\u27s conduct. On the other side, Lebanon\u27s conduct in relation to Israel\u27s claims and especially with regard to Hezbollah\u27s activities will carefully be scrutinized in the light of public international law rules. In this framework, the question of States’ lawful reactions to non-State actors’ use of force will be thoroughly examined. Hence, in this respect, the article will assess not only ius contra bellum rules but also international law of State responsibility as well as the right to resort to forcible countermeasures and UN law (notably Security Council prerogatives under United Nations Charter Chapter VII). In conclusion, the author aims to determine Israel, Lebanon (and Hezbollah\u27s) responsibility in the context of this chapter of the Middle East Question
Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways.
No full textAutosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant cells and kidneys to investigate the metabolic reprogramming of this pathology. We show that loss of Pkd1 leads to profound metabolic changes that affect glycolysis, mitochondrial metabolism, and fatty acid synthesis (FAS). We find that Pkd1-mutant cells preferentially use glutamine to fuel the TCA cycle and to sustain FAS. Interfering with either glutamine uptake or FAS retards cell growth and survival. We also find that glutamine is diverted to asparagine via asparagine synthetase (ASNS). Transcriptional profiling of PKD1-mutant human kidneys confirmed these alterations. We find that silencing of Asns is lethal in Pkd1-mutant cells when combined with glucose deprivation, suggesting therapeutic approaches for ADPKD
Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis
No full textAccumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria. We show that expression of Trim17 is increased both at the mRNA and protein level in several in vitro models of transcription-dependent neuronal apoptosis. Expression of Trim17 is controlled by the PI3K/Akt/GSK3 pathway in cerebellar granule neurons (CGN). Moreover, the Trim17 protein is expressed in vivo, in apoptotic neurons that naturally die during post-natal cerebellar development. Overexpression of active Trim17 in primary CGN was sufficient to induce the intrinsic pathway of apoptosis in survival conditions. This pro-apoptotic effect was abolished in Bax(-/-) neurons and depended on the E3 activity of Trim17 conferred by its RING domain. Furthermore, knock-down of endogenous Trim17 and overexpression of dominant-negative mutants of Trim17 blocked trophic factor withdrawal-induced apoptosis both in CGN and in sympathetic neurons. Collectively, our data are the first to assign a cellular function to Trim17 by showing that its E3 activity is both necessary and sufficient for the initiation of neuronal apoptosis. Cell Death and Differentiation (2010) 17, 1928-1941; doi: 10.1038/cdd.2010.73; published online 18 June 201
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