1,721,025 research outputs found

    Quality of life and functions after chemoradiation for rectal cancer: A review of recent publications

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    We have systematically reviewed studies published in the last three years on patients' self-reported evaluations of quality of life (QoL) and functions after chemoradiotherapy (CRT) for rectal cancer. Overall, the findings from 13 studies confirmed that CRT negatively affect functions and, consequently, patients' QoL, especially for bowel, role, and social function. The studies' heterogeneity limited the possibility of comparison among findings. We discuss and comment on the ideal characteristics of studies assessing QoL and function. We emphasise how this type of evidence is relevant to decision-making at all levels of health-care practice. © 2013 Springer Science+Business Media New York

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Solution Bundles of Markov Performability Models through Adaptive Cross Approximation

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    A technique to approximate solution bundles, i.e., solutions of a parametric model where parameters are treated as independent variables instead of constants, is presented for Markov models. Analyses based on an approximated solution bundle are more efficient than those that solve the model for all combinations of parameters' values separately. In this paper the idea is to properly adapt low rank tensor approximation techniques, and in particular Adaptive Cross Approximation, to the evaluation of performability attributes. Application on exemplary case studies confirms the advantages of the new solution technique with respect to solving the model for all time and parameters' combinations

    Implicit Reward Structures for Implicit Reliability Models

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    A new methodology for effective definition and efficient evaluation of dependability-related properties is proposed. The analysis targets the systems composed of a large number of components, each one modeled implicitly through high-level formalisms, such as stochastic Petri nets. Since the component models are implicit, the reward structure that characterizes the dependability properties has to be implicit as well. Therefore, we present a new formalism to specify those reward structures. The focus here is on component models that can be mapped to stochastic automata with one or several absorbing states so that the system model can be mapped to a stochastic automata network with one or several absorbing states. Correspondingly, the new reward structure defined on each component's model is mapped to a reward vector so that the dependability-related properties of the system are expressed through a newly introduced measure defined starting from those reward vectors. A simple, yet representative, case study is adopted to show the feasibility of the method

    Random Bad State Estimator to Address False Data Injection in Critical Infrastructures

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    Given their crucial role for a society and economy, an essential component of critical infrastructures is the Bad State Estimator (BSE), responsible for detecting malfunctions affecting elements of the physical infrastructure. In the past, the BSE has been conceived to mainly cope with accidental faults, under assumptions characterizing their occurrence. However, evolution of the addressed systems category consisting in pervasiveness of ICT-based control towards increasing smartness, paired with the openness of the operational environment, contributed to expose critical infrastructures to intentional attacks, e.g. exploited through False Data Injection (FDI). In the flow of studies focusing on enhancements of the traditional BSE to account for FDI attacks, this paper proposes a new solution that introduces randomness elements in the diagnosis process, to improve detection abilities and mitigate potentially catastrophic common-mode errors. Differently from existing alternatives, the strength of this new technique is that it does not require any additional components or alternative source of information with respect to the classic BSE. Numerical experiments conducted on two IEEE transmission grid tests, taken as representative use cases, show the applicability and benefits of the new solution

    Patient-reported outcomes after neoadjuvant therapy for rectal cancer: A systematic review

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    Neoadjuvant therapy followed by total mesorectal excision is standard of care for locally advanced rectal cancer. However, this approach has been previously shown to be associated with high rate of morbidity and it may have a negative effect on patients' reported outcomes (PROs). In order to summarize findings on the effect of the neoadjuvant approach on PROs, we systematically reviewed articles published in the last five years. Thirty-five articles met the inclusion criteria. Ten articles compared the effect of surgery with and without neoadjuvant therapy, six articles compared different neoadjuvant therapies, ten articles reported on patients who were all treated with neoadjuvant therapy, and nine articles examined the effect of neoadjuvant therapy in the analyses. The results are summarized by function investigated and critically commented. © 2014 Informa UK, Ltd
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