1,721,397 research outputs found
Adenocarcinoma of the esophagogastric junction
No full textEsophagogastric junction (EGJ) cancer is, among solid cancers, the fastest growing tumor in terms of incidence in Western countries, and due to the lifestyle changes in developing and newly industrialized countries, this trend is expected to intensify worldwide. EGJ adenocarcinoma, however, is poorly defined: first because it is not an “organ disease” but a “zone disease,” and also because among EGJ cancers there can be included different diseases with different etiology and different biology. Eastern countries, led by Japan, taught us the correct management of gastric cancer and provided us guide- lines for the treatment of esophageal squamous cell carcinoma. However when we talk about EGJ adenocarcinoma, it is a separate entity and is more properly a Western reality; therefore, Western countries should systematize and give answers to the relevant issues this cancer raises, along the road to standardization. Europe has been leading the evolution of thought on EGJ carcinoma, especially thanks to Siewert and the German school, which cre- ated the classification that still is used as a guide by clinicians in therapeutic strategy planning. With the introduction of the latest version of the TNM, all EGJ cancers were defined as esophageal cancers, suggesting the possibility of a uniform treatment. In the era of tailored treatment and targeted therapy, we may wonder if what we already have is enough or if we need to go further on, especially considering the lack of homogeneity in the choice of multi- modal treatments according only to topography. I then decided that it was still necessary to concentrate just on this difficult cancer and, together with my co-workers Simone Giacopuzzi and Andrea Zanoni, I decided to write a book, which we hope will shed a little light on such a complex and current topic. To make this book more international, I invited to participate, in order to give their significant key to interpretation, also some surgeons of renowned importance in the field. I would like to thank them all deeply for their contributions. Based on the experience of the Italian Research Group for Gastric Cancer (GIRCG) and the European Chapter of IGCA, we hope that this collaboration will start to build an even closer international cooperation with the opportu- nity to create a European network on EGJ adenocarcinoma
L’ espressione di BIRC3 come predittore di resistenza alla chemioradioterapia neoadiuvante nell’adenocarcinoma del cardias e nel carcinoma squamoso dell’esofago
No full textNell'ottica di un tailored treatment nella gestione delle malattie neoplastiche dell'esofago abbiamo valutato la possibilità di identificare un marcatore molecolare di risposta alla terapia. L’espressione di BIRC3 regolata da TAK1 potrebbe essere responsabile della resistenza alla chemio-radioterapia neoadiuvante nel trattamento dell’adenocarcinoma dell’esofago e della giunzione esofago-gastrica (EGJ) mentre non pare avere un ruolo rilevante nei carcinomi squamocellulari.As part of a tailored treatment in the management of neoplastic diseases of the esophagus, we evaluated the possibility to identify a molecular marker of response to therapy. The expression of BIRC3 regulated by TAK1 may be responsible for resistance to neoadjuvant chemo-radiotherapy in the treatment of the esophageal and esophageal-gastric junction (EGJ) adenocarcinoma and does not seem to have a major role in squamous cell carcinomas
Progettare lo sviluppo : interpretazioni a partire dall'esperienza dell'“Integrated multi-sectoral project to improve the Food Security situation in Sekota, Dehana, and Ziquala districts – Waghamra zone –Amhara regional state”
No full textASO Author Reflections: Recurrence After Pathological Complete Response in Esophageal Cancer: Analysis of Risk Factors for this Unexpected Event
No full textASO Author Reflections: Recurrence After Pathological Complete Response in Esophageal Cancer: Analysis of Risk Factors for this Unexpected Even
Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA)
No full textBackground: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy. Methods: Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018-December 2018. Definitions for AL and CN were those set out by the Oesophageal Complications Consensus Group. Univariate and multivariate analyses were performed to identify risk factors for both AL and CN. A risk score was then produced for both AL and CN using the derivation set, then internally validated using the validation set. Results: This study included 2247 oesophagectomies across 137 hospitals in 41 countries. The AL rate was 14.2% and CN rate was 2.7%. Preoperative factors that were independent predictors of AL were cardiovascular comorbidity and chronic obstructive pulmonary disease. The risk scoring model showed insufficient predictive ability in internal validation (area under the receiver-operating-characteristic curve [AUROC] = 0.618). Preoperative factors that were independent predictors of CN were: body mass index, Eastern Cooperative Oncology Group performance status, previous myocardial infarction and smoking history. These were converted into a risk-scoring model and internally validated using the validation set with an AUROC of 0.775. Conclusion: Despite a large dataset, AL proves difficult to predict using preoperative factors. The risk-scoring model for CN provides an internally validated tool to estimate a patient's risk preoperatively
Postoperative anaemia increases unplanned readmission: an international prospective cohort study of patients undergoing major abdominal surgery
No full textPostoperative anaemia increases unplanned
readmission: an international prospective cohort study
of patients undergoing major abdominal surger
The green indocyanine: the meaning of one tracer for the intra-peri operative imaging and vascular evaluation in the reconstructive surgery of head and neck: an experimental multidisciplinary study
No full textThe objective of this study was to evaluate the feasibility and reproducibility of a new diagnostic approach through the flow injection of green indocyanine such as the intraoperative and perioperative vascularization in the reconstruction of various anatomical areas with pedunculated or microsurgical free flaps, the identification of the sentinel lymph node in the latero cervical emptying or the assessment of the quality of anastomoses in organ transplantation. The study involved ten patients who underwent reconstructive procedures with different surgical approaches for reconstructive surgery of head and neck. An intraoperative check was performed in several stages to assess the real perfusion status of the treated area. Indocyanine green was used in all the patients in association with an intraoperative imaging diagnostic system. Indocyanine green showed in all the cases a full highlight of central and peripheral vascularization. Furthermore, this imaging system allowed a satisfactory and rapid intraoperative evaluation of the vascular tree and a high sensitivity in detection of the sentinel lymph node in latero cervical emptying. Despite the limited sample, the results suggest that the intraoperative administration of indocyanine green may represent a valid evaluating system for reconstructed flap perfusion and for sentinel lymph node identification in oncological surger
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
