247 research outputs found
Natural isocoumarins: Structural styles and biological activities, the revelations carry on ….
No full textShabir, Ghulam, Saeed, Aamer, El-Seedi, Hesham R. (2021): Natural isocoumarins: Structural styles and biological activities, the revelations carry on …. Phytochemistry (112568) 181: 1-23, DOI: 10.1016/j.phytochem.2020.112568, URL: http://dx.doi.org/10.1016/j.phytochem.2020.11256
Fig. 1 in Natural isocoumarins: Structural styles and biological activities, the revelations carry on ….
No full textFig. 1. The effect of various substituents on biological activities of natural isocoumarins.Published as part of Shabir, Ghulam, Saeed, Aamer & El-Seedi, Hesham R., 2021, Natural isocoumarins: Structural styles and biological activities, the revelations carry on …., pp. 1-23 in Phytochemistry (112568) 181 on page 18, DOI: 10.1016/j.phytochem.2020.112568, http://zenodo.org/record/829116
Evaluation and Application of Best Practice in Analytical Method Validation
No full textThe coherent body of research described in the existing published work is
concerned with new assay method development and validation using novel
systematic approaches for pharmaceutical and diagnostic compounds.
The first stage of the research was to study how analytical method development
and validation are typically carried out at present and to formulate this into a
simple step-by-step approach. Such a template and protocol was not only used
as the foundation of this research programme but could also serve as a simple
systematic guide for other practitioners and those new to the field. Furthermore,
it was recognised that this protocol should satisfy the requirements of the most
strategically important regulatory agencies.
The second stage of this research involved evaluation and application of the
above validation approach to new methods that were developed for a diverse
range of analytes and samples. A new purity assay for 1,10-phenanthroline-5,6-
dione and 4,7-phenanthroline-5,6-dione using high-performance liquid
chromatography (HPLC) was developed and validated. Impurities in these
compounds were identified by liquid chromatography-mass spectrometry (LCMS).
Best practice in method development and validation is equally important in
the analysis of both active components and excipients in formulated products. In
the first case, a liquid chromatography assay method for determining the content
of 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide in a gel formulation was
developed and validated. In the second case, the individual contents of three phydroxy
benzoic acid ester preservatives in a complex multi-component sample
were determined following the development and validation of a liquid
chromatography method.
Finally, the validation approach was evaluated as applied to another analytical
technique. Here, gas chromatography (GC) successfully used to develop a novel
assay for p-cymene in tea tree oil formulations presented different analytical
problems because of the very complex nature of this natural product. Stability
study information to increase the shelf life of the product and validation data for
the analytical method for p-cymene content was critically evaluated.
iv
In essence, the critical review of the requirements for method validation for
various agencies and the subsequent preparation of guidelines on how to go
about method validation have had a significant impact on how analytical
practitioners worldwide go about method development and, more importantly,
method validation. Further it was possible to apply these guidelines to conduct a
series of effective, successful method validation for assays involving a range of
typical pharmaceutical samples
Understanding Ḥadīth, “Father of Prophet Muḥammad in Hell” In Shabir Ally's Perspective
Full text linkShabir Ally is a Canadian Islamic preacher and apologist. He was interviewed on a YouTube channel named ‘Let The Quran Speak’ about the prophet’s father in hell. However, his explanation is only a brief explanation. Meanwhile, understanding the Ḥadīth of the Prophet Muḥammad Ṣallallahu ‘Alayhi Wa Sallam. Must also use the methodology of Ḥadīth knowledge and the opinions of experts about the true meaning contained in the Ḥadīth. This article aims to provide a more complete explanation of what has been explained by Dr. Shabir Ally in his interview session. This research is a type of literature review research. The result of this article can be summarized as follows: Shabir Ally is in the middle position, neither saying the Prophet's father was in hell nor saying the Prophet's father was saved from the torment of hell. Moreover, the words of the prophet who said, 'My father is also in hell,' are just additions to the story by the people who told that event. However, the author(s) have not found the primary basis for Shabir Ally to say that so far
Strong resonance interaction in 4-{4-[2-(3-dicyanomethylene-5,5-dimethyl-cyclohex-1-enyl)-vinyl]-phenoxy}-butyric acid. Structural, electrochemistry and spectroscopic properties complemented by Natural Bond Orbital and Hirshfeld surface analysis
No full textThe present investigation deals with the synthesis and characterization of (E)-4-(4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenoxy)butanoic acid (SLN-01) and its electrochemical and structural study. The compound SLN-01, has been characterized by UV, FTIR, and multinuclear (1H and 13C) NMR spectroscopic studies. DFT calculations were used to estimate redox potential and band gap energies of SLN-01. It's molecular and crystal structures were determined by single-crystal X-ray analysis. The compound (E)-4-(4-(2-(3-(Dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenoxy) butanoic acid (SLN-01) was crystallized in the triclinic geometry. The Hirshfeld surface analysis was conducted to confirm the supramolecular association formed by the individual conformers and overall packing in the crystal. Natural Bond Orbital population analysis was performed to understand the electronic interactions between the donor and acceptor moieties in the molecule. The targeted compound exhibited a strong absorption at 416 nm (ε= 67,762 ± 4600 L mol−1 cm−1) with emission (λem) at 575 nm (at excitation wavelength λex= 430 nm).Fil: Shabir, Ghulam. Quaid-I-Azam University; PakistánFil: Arooj, Sama. Quaid-I-Azam University; PakistánFil: Saeed, Aamer. Quaid-I-Azam University; PakistánFil: Hashmi, Muhammad Zaffar. University Of The Punjab; PakistánFil: Hökelek, Tuncer. Hacettepe University; TurquíaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentin
Understanding Ḥadīth, “Father of Prophet Muḥammad in Hell” In Shabir Ally's Perspective
Full text linkShabir Ally is a Canadian Islamic preacher and apologist. He was interviewed on a YouTube channel named ‘Let The Quran Speak’ about the prophet’s father in hell. However, his explanation is only a brief explanation. Meanwhile, understanding the Ḥadīth of the Prophet Muḥammad Ṣallallahu ‘Alayhi Wa Sallam. Must also use the methodology of Ḥadīth knowledge and the opinions of experts about the true meaning contained in the Ḥadīth. This article aims to provide a more complete explanation of what has been explained by Dr. Shabir Ally in his interview session. This research is a type of literature review research. The result of this article can be summarized as follows: Shabir Ally is in the middle position, neither saying the Prophet's father was in hell nor saying the Prophet's father was saved from the torment of hell. Moreover, the words of the prophet who said, 'My father is also in hell,' are just additions to the story by the people who told that event. However, the author(s) have not found the primary basis for Shabir Ally to say that so far
Current developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3- (substituted)thioureas: advances Continue…
No full text1-(acyl/aroyl)-3-(substituted)thioureas are exciting structures in the fields of organic synthesis, material sciences, and biomedical research. Of particular significance is the fact that acyl thiourea derivatives have been demonstrated to be highly exceptional ligands and their coordination compounds have extensively been investigated in the synthesis of pharmaceuticals and agrochemical ingredients. Moreover, these structural motifs are enjoying the prestigious status as versatile synthons in heterocyclic syntheses. Therefore, the progress to introduce functionalization on the backbone of 1-(acyl/aroyl)-3-(substituted)thioureas is highly desirable. This account summarizes our efforts to capture recent documented achievements by various research groups.Fil: Saeed, Aamer. Quaid-i-azam University; PakistánFil: Mustafa, Muhammad Naeem. Quaid-i-azam University; PakistánFil: Zain-ul-Abideen, Muhammad. Quaid-i-azam University; PakistánFil: Shabir, Ghulam. Quaid-i-azam University; PakistánFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Flörke, Ulrich. Universität Paderborn; Alemani
Public Feelings and Other Acts
No full textIn his debut, Ray Shabir shines a spotlight to the realm of his adolescence, before facing the inevitable truth of growing up. In Public Feelings & Other Acts, a collection of theatrical range of works, Ray raises his glass in his own tribute of youth. Public Feelings & Other Acts matures into a kaleidoscopic memoir. It opens up to the reader through a series of essays, poetries, proses, and other forms of writings. Completed with striking visuals that aids his storytelling, the author takes on his own personal accounts on growing up, from creativity to partying to loneliness to heartache. The book is a documentation of the author´s personal period of time, in order to reflect and acknowledge his own coming-of-age before moving forward. Written in a voice that is unapologetically personal yet critically distant at the same time, he makes his odyssey towards adulthood - unquestionably his own
Conformational and crystal structure of acyl thiourea compounds: The case of the simple (2,2-dimethyl-propionyl) thiourea derivative
No full textA novel and simple compound from the family of 1-acyl thioureas, namely (2,2-dimethyl-propionyl) thiourea (also named as N-carbamothioyl pivalamide), has been prepared. It has been fully characterized by microelemental analysis, FTIR, multinuclear (1 H and 13C) NMR and mass spectroscopy, and the crystal structure determined by using single crystal X-ray diffraction study. Intramolecular NeH/O]C hydrogen bond occurs between the carbonyl (C]O) and thioamide (eNH2) groups forming a S6 pseudoring that stabilize the conformation. The Natural Bond Orbital (NBO) population analysis demonstrates that the hyperconjugative remote interaction between the donor lone pairs located on the carbonyl oxygen and the NeH group, i.e. lpO / s*(NeH) is responsible for the preferred conformation. Intermolecular interactions in the crystal are characterized by hydrogen-bonding networks between the carbamide (NH2) groups and the thiocarbonyl bond (C]S), including R2 2ð8Þ dimer motifs promoted by the NeH/S]C synthon. Hirshfeld surface analysis was performed for visualizing, exploring and quantifying intermolecular interactions present in the crystal structure.Fil: Nossa González, Diana Lisseth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Saeed, Aamer. Quaid-i-azam University; PakistánFil: Shabir, Ghulam. Quaid-i-azam University; PakistánFil: Flörke, Ulrich. Universitat Paderborn; AlemaniaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentin
On the planarity of the cyclobutane ring in the crystal of dimethyl 2,4-bis(3,4-dimethoxyphenyl)cyclobutane-1,3-dicarboxylate: a natural bond orbital and Hirshfeld surface analysis study
No full textDimethyl 2,4-bis(3,4-dimethoxyphenyl)cyclobutane-1,3-dicarboxylate was synthesized by the dimerization of methyl 3-(3,4-dimethoxyphenyl)acrylate in methanol under photoirradiation by direct sunlight. Its molecular and crystal structures were determined by single crystal X-ray analysis. The molecule is located at the center of inversion. Thus, the asymmetric unit contains only one half of the molecule, and the central four-membered ring is in a slightly distorted square-planar arrangement. The residues on opposite sides of the four-membered ring are located on different faces of the ring, resembling the typical α-form for truxillic acid derivatives. The analysis of natural bond orbital population was performed and the effect of the σC-H → σC-H∗ hyperconjugative interactions is determined. In the crystal structure, the C-HMthcarbx⋯OCarbx and C-HMthoxy⋯OMthoxy [Mthcarbx = methylcarboxylate, Carbx = carboxylate and Mthoxy = methoxy] hydrogen bonds, enclosing R22(12) and R22(18) ring motifs, link the molecules into a three-dimensional architecture, in which they may be effective in the stabilization of the structure. The Hirshfeld surface analysis of the crystal structure confirms that the most important contributions for the crystal packing are from H⋯H (51.8%), H⋯O/O⋯H (31.5%) and H⋯C/C⋯H (15.3%) interactions. Hydrogen bonding and van der Waals interactions are dominant interactions in crystal packing.Fil: Shabir, Ghulam. Quaid-I-Azam University. Department of Chemistry; PakistánFil: Saeed, Aamer. Quaid-I-Azam University. Department of Chemistry; PakistánFil: Qasim, Muhammad. Quaid-I-Azam University. Department of Chemistry; PakistánFil: Bolte, Michael. J. W. Goethe-Universität. Institut für Anorganische Chemie; AlemaniaFil: Hökelek, Tuncer. Hacettepe University. Department of Physics; TurquíaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentin
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