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From urological tissue engineering to conduit innovations
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162524.pdf (Publisher’s version ) (Open Access)Radboud University, 06 januari 2017Promotor : Feitz, W.F.J. Co-promotores : Oosterwijk, E., Geutjes, P.J
Urogenital tissue engineering using new hybrid biomaterials
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182801.pdf (Publisher’s version ) (Open Access)Radboud University, 02 februari 2018Promotor : Feitz, W.F.J. Co-promotores : Oosterwijk, E., Geutjes, P.J
Tubular collagen-based bioscaffolds for tissue engineering
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97473.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 15 september 2011Promotores : Brock, R.E., Feitz, W.F.J. Co-promotores : Kuppevelt, A.H.M.S.M. van, Daamen, W.F., Geutjes, P.J
Fetal therapy for spina bifida in sheep model using tissue engineering
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92574.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 14 februari 2012Promotores : Feitz, W.F.J., Berg, P.P. van den, Lotgering, F.K. Co-promotores : Kuppevelt, T. van, Geutjes, P.J.148 p
Tissue Engineering for Congenital Anomalies concerning the Bladder and Abdominal Wall.
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127375.pdf (Publisher’s version ) (Open Access)Severe congenital anomalies can have a large impact on the lives of patients. With tissue engineering techniques damaged or absent tissue can be regenerated, which can become a treatment option for congenital anomalies. In this thesis treatment possibilities for congenital anomalies concerning the bladder, for instance bladder exstrophy or myelomeningocele, and the abdominal wall, for instance gastroschisis, are described.
A bladder exstrophy was surgically created in a fetal lamb, which largely resembled the anomaly in humans. In this model for diseased bladder we regenerated bladder tissue with a scaffold of bovine type I collagen, which served as an extracellular matrix. This tissue consisted of a urothelial layer, angiogenesis, smooth muscle cells and nerve fibers. The addition of growth factors improved angiogenesis, and the ingrowth of urothelium and smooth muscle cells. However, for a significant impact on clinical outcome, larger constructs need to be tested.
A tubular collagen scaffold was combined with a polymer mesh and tested in a porcine model for its application as an incontinent urinary conduit, as an alternative for the current use of intestinal tissue. Although the construct served as a conduit in 50% of the animals, improvements need to be made before this technique can be studied in humans.
In a fetal lamb model for gastroschisis the collagen scaffold was used to close the abdominal wall during the fetal period. Furthermore, we studied the coverage of the fetal bowel when it was left eviscerated outside the abdominal cavity. After birth less adhesions and fibrous peel was seen in the treated groups compared to the gastroschisis group. Skin and connective tissue with muscle cells replaced the scaffold. This treatment option may become an alternative for postnatal repair of abdominal wall defects when minimal invasive techniques (fetoscopy) improve, hereby decreasing the risk of premature delivery.Radboud Universiteit Nijmegen, 11 juli 2014Promotores : Feitz, W.F.J., Wijnen, R.H.M. Co-promotores : Geutjes, P.J., Kuppevelt, A.H.M.S.M. van, Daamen, W.F
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Novel tools for tissue engineering:Development and evaluation of collagen-based biomaterials.
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82964.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 11 november 2010Promotor : Brock, R.E. Co-promotores : Kuppevelt, A.H.M.S.M. van, Daamen, W.F., Vliet, J.A. van der112 p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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