5,217 research outputs found
Letter from J. R. Eakin to Stephen Mather
No full textLetter from J. R. Eakin to Stephen T. Mather about expenses and reconstruction of the Kaibab Trail
Service-oriented models for audiovisual content storage
No full textWhat are the important topics to understand if involved with storage services to hold digital audiovisual content? This report takes a look at how content is created and moves into and out of storage; the storage service value networks and architectures found now and expected in the future; what sort of data transfer is expected to and from an audiovisual archive; what transfer protocols to use; and a summary of security and interface issues
Letter from J. R. Eakin to Stephen Mather
No full textLetter from J. R. Eaking to the National Park Service director about changes to the Grand Canyon National Park boundaries, and access to water near the Buggeln property on Desert View road
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury
No full textMechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death-risk factors for the development of osteoarthritis. Melanocortin peptides and their receptors mediate anti-inflammatory and pro-resolving mechanisms in chondrocytes. This study aimed to investigate the potential chondroprotective properties of α-MSH and [DTRP8]-γ-MSH in mechanically injured cartilage explants, their ability to inhibit pro-inflammatory and stimulate anti-inflammatory cytokines in in situ and in freshly-isolated articular chondrocytes.
METHODS:
The effect of melanocortins on in situ chondrocyte viability was investigated using confocal laser scanning microscopy of bovine articular cartilage explants, subjected to a single blunt impact (1.14N, 6.47kPa) delivered by a drop tower. Chondroprotective effects of α-MSH, [DTRP8]-γ-MSH and dexamethasone on cytokine release by TNF-α-activated freshly-isolated articular chondrocytes/mechanically injured cartilage explants were investigated by ELISA.
RESULTS:
A single impact to cartilage caused discreet areas of chondrocyte death, accompanied by pro-inflammatory cytokine release; both parameters were modulated by α-MSH, [DTRP8]-γ-MSH and dexamethasone. Melanocortin pre-treatment of TNF-α-stimulated freshly-isolated chondrocytes resulted in a bell-shaped inhibition in IL-1β, IL-6 and IL-8, and elevation of IL-10 production. The MC3/4 antagonist, SHU9119, abrogated the effect of [DTRP8]-γ-MSH but not α-MSH on cytokine release.
CONCLUSION:
Melanocortin peptide pre-treatment prevented chondrocyte death following mechanical impact to cartilage and led to a marked reduction of pro-inflammatory cytokines, whilst prompting the production of anti-inflammatory/pro-resolving cytokine IL-10. Development of small molecule agonists towards melanocortin receptors could thus be a viable approach for preventing chondrocyte inflammation and death within cartilage and represent an alternative approach for the treatment of osteoarthritis
"Greensboro, City of Racial Paradoxes", by Stephen J. Goldfarb, circa 1993
No full textAn article written by Stephen J. Goldfrab. This article discusses the civil rights movement in Greensboro, N.C. during the 1960s. The city had a paradoxical nature, being both racially moderate and having segregated public facilities and employment. The author of the article, Stephen J. Goldfrab, uses interviews to tell the story of the sit-ins and demonstrations that led to desegregation in Greensboro, but neglects to discuss the role of voting in the civil rights movement. The author refers to Historian William H. Chafes to give context about Greensboro, N.C. 1 page
Anti-inflammatory and antiosteo-clastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
No full textThe development of biological therapies has improved management of rheumatoid arthritis. However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit their use, making it imperative to identify new targets for drug development programs. Here we investigated the melanocortin-receptor type 3 (MC3) pathway. Gene-deficient mice were subjected to a model of serum-transfer-induced arthritis and joints analyzed for gene expression (cytokines, MCs) and morphology. Pharmacological analyses were also conducted in this model. Osteoclastogenesis was studied from bone marrow cells. Mc3−/− mice displayed an exacerbated inflammatory arthritis, associated with prominent bone erosion and higher articular expression of Rankl. Osteoclastogenesis studied from Mc3−/− bone marrow cells revealed a higher degree of responsiveness to Rankl, linked to prolonged NF-κB activation compared to wild types. Up-regulation of a discrete set of inflammatory genes, including Il-1β, Il-6, and Nos2, was measured in Mc3−/− mice, and a marked up-regulation of joint Mc3 accompanied arthritis resolution in wild-type mice. Administration of an MC3 agonist, D[Trp8]-γ-MSH, attenuated disease incidence and severity in wild-type but not Mc3−/− mice. Overall, these findings identify MC3-mediated signaling as a beneficial pathway in experimental arthritis; hence this receptor is a novel target for the development of therapeutics for arthritis.—Patel, H. B., Bombardieri, M., Sampaio, A. L. F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S. J., Pitzalis, C., Perretti, M. Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
Ideology, consciousness, and inner-city redevelopment: The case of Stephen Goldsmith\u27s Indianapolis
No full textAn analysis of Mayor Stephen Goldsmith\u27s housing and community development policies in Indianapolis from 1991-1999. Evaluation of how the mayor\u27s populist ideology influenced affordable housing production in the city\u27s most distressed neighborhoods. (author-supplied description
Muriel Spark as auto-biographer in <i>Curriculum</i> <i>Vitae</i>
No full textExamining Muriel Spark's main aims as an auto-biographer in her work Curriculum Vitae brings important resources in the exploration of the genre of autobiographical writing. This with the theoretical engagement, allows consideration of the critical issues surrounding the roles of author and reader in the construction of the literary self. Spark demands the reader participate in the constructon of textual meaning; overturning the conventions of autobiography, satirising its claims to omniscience and highlighting the impossibility of an authentic voice with regard to the self
Austin Papers: Series III, 1835
No full textCopy of transcript for a letter from Stephen F. Austin to J. B. Miller and W. Grayson informing them that the amnesty law published that month covers his case and that he will leave Mexico City after getting his bail bonds cancelled. Austin also mentions that Santa Anna has informed Austin that he is "friendly towards Texas." Austin asks Miller and Grayson to pass this letter along to his sister
2021 Judge Horace J. Johnson, Jr. Lecture on Race, Law and Policy with Stephen Carter
No full textYale Law School\u27s Cromwell Professor Stephen Carter served as the inaugural Judge Horace J. Johnson, Jr. Lecturer on Race, Law and Policy
Carter is the William Nelson Cromwell Professor of Law at Yale Law School, where he has been a member of the faculty since 1982. He is the author of 15 books, as well as six novels, including The Emperor of Ocean Park, which spent 11 weeks on The New York Times bestseller list, and The Impeachment of Abraham Lincoln, a fictional account of a trial of Lincoln in the Senate for high crimes and misdemeanors. Carter is a graduate of Stanford University and Yale Law School. He served as a law clerk for Justice Thurgood Marshall at the U.S. Supreme Court and Judge Spottswood W. Robinson III of the U.S. Court of Appeals for the District of Columbia Circuit. Among the accolades Carter\u27s work has received are the Louisville-Grawemeyer Award in Religion, the Anisfield-Wolf Award for Fiction and the Paul M. Bator Award. He has also served on the Pulitzer Prize fiction jury.
With support from UGA\u27s Presidential Task Force on Race, Ethnicity and Community, the School of Law and School of Public and International Affairs have established the Judge Horace J. Johnson, Jr. Lecture on Race, Law and Policy in honor of the late jurist, who was a trailblazer for the Black community in Georgia. Johnson was a pioneer throughout his life. He was one of five students who helped desegregate Newton County, Georgia, schools in the 1960s. He graduated from the UGA School of Law in 1982. After briefly working in Atlanta, Johnson became the first Black attorney to practice in his home county. In 2002, he became the first Black Superior Court judge to serve in the Alcovy Judicial Circuit when then-Gov. Roy Barnes appointed him to the post. He remained in this role until his death in July 2020
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