1,721,056 research outputs found

    Data fusion of Raman spectra in MSPC for fault detection and diagnosis in pharmaceutical manufacturing

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    This study investigates the use of Raman spectroscopy fused with other types of data (e.g., pH, temperature and turbidity) for multivariate statistical process control of two pharmaceutical case studies: one simulated industrial-scale fed-batch process for the production of penicillin and one real lab-scale crystallization process. The monitoring schemes are built on local principal component analysis models and hyper-parameters are tuned with regards to highest accuracy in fault detection. Accuracies above 90% are obtained for all types of data and level of DF. Furthermore, for the first case study the model built solely on spectra achieves higher fault detection rates, when only considering faults that also result in off-specification quality. This is supported by the fact that the fault is not necessarily detected when it occurs, but rather when it starts to affect quality variables as measured by the spectra

    Artificial neural networks for rapid WWTP performance evaluation: Methodology and case study

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    Reliable performance evaluation of wastewater treatment plants (WWTPs) can be done by simulating the plant behavior over a wide range of influent disturbances, including series of rain events with different intensity and duration, seasonal temperature variations, holiday effects, etc. Such simulation-based WWTP performance evaluations are in practice limited by the long simulation time of the mechanistic WWTP models. By moderate simplification (avoiding big losses in prediction accuracy) of the mechanistic WWTP model only a limited reduction of the simulation time can be achieved. The approach proposed in this paper combines an influent disturbance generator with a mechanistic WWTP model for generating a limited sequence of training data (4 months of dynamic data). An antificial neural network (ANN) is then trained on the available WWTP input-output data, and is subsequently used to simulate the remainder of the influent time series (20 years of dynamic data) generated with the influent disturbance generator. It is demonstrated that the ANN reduces simulation time by a factor of 36, even when including the time needed for the generation of training data and for ANN training. For repeated integrated urban wastewater system simulations that do not require repeated training of the ANN, the ANN reduces simulation time by a factor of 1300 compared to the mechanistic model. ANN prediction of effluent ammonium, BOD5 and total suspended solids was good when compared to mechanistic WWTP model predictions, whereas prediction of effluent COD and total nitrogen concentrations was a bit less satisfactory. With correlation coefficients R-2 > 0.95 and prediction errors lower than 10%, the accuracy of the ANN is sufficient for applications in simulation-based WWTP design and simulation of integrated urban wastewater systems, especially when taking into account the uncertainties related to mechanistic WWTP modeling. (c) 2006 Elsevier Ltd. All rights reserved

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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