1,721,022 research outputs found
Nose-to-brain delivery
No full textNose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects. For these reasons the development of nasal formulations able to deliver the drug directly into the brain is of increasing importance. This Editorial regards the contributions present in the Special Issue “Nose-to-Brain Delivery”
Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method
No full textNon disponibil
Synthesis and pharmacological evaluation of 5,6-dihydrobenzo[f] cinnolin-2(3H)ones analogues of antihypertensive and antiaggregating benzo[h]cinnolinones
No full textSynthesis and pharmacological evaluation of 4a-methyl-4,4a,5,6-tetrahydrothieno[2,3-h]cinnolin-3(2H)-ones
No full textNanotechnology-based rose Bengal: A broad-spectrum biomedical tool
No full textRose Bengal is an anionic xanthene dye, a derivative of fluorescein, born in the 19th century as a textile dye; to date, it is known primarily in ophthalmology as a diagnostic tool and demonstrated to be promising in the biomedical field. Rose Bengal intrinsic cytotoxicity against tumor and microbial cells is responsible for its therapeutic potential; moreover, it is a sono-photosensitizer drug suitable for sono-photodynamic therapy. Due to its disadvantageous bio-pharmaceutical profile, Rose Bengal is approved only as an ocular diagnostic stain and has been designated by the Food and Drug Administration as an orphan drug to treat certain cancers. Two main pharmaceutical approaches such as molecular structural changes and drug delivery systems were investigated to overcome Rose Bengal limits. The current review reports the physical-chemical profile and pharmacokinetic properties of Rose Bengal and presents a short overview of its biomedical applications. The review focuses on Rose Bengal nanosized delivery systems already developed to outline the current research topics and to assess whether nanotechnology can maximize its therapeutic potential overcoming its limits. Through the revision of Rose Bengal research articles about this topic, it emerges that a proper Rose Bengal nanosized delivery system can efficiently improve its biopharmaceutical profile and enhance Rose Bengal-based therapy
Opinion Paper: Selective Targeting of Liver Nodules. Present Situation and New Challenges to Enhance Indocyanine Green Captation from Colorectal Liver Metastases
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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