827 research outputs found
Seminal contributions of Timothy J. Crow
No full text© The Author(s), 2025. Published by Cambridge
University Press. This is an Open Access article,
distributed under the terms of the Creative
Commons Attribution licence (http://
creativecommons.org/licenses/by/4.0), which
permits unrestricted re-use, distribution and
reproduction, provided the original article is
properly cited.We recall the life and work of Timothy J. Crow, whose contributions provided great insights into the pathophysiology of schizophrenia and continue to shape many questions in the field. We compile his key works relating to psychotic disorders, focusing on the trajectory of his theoretical stance. Our account is interlaced with our own interpretation of the evidence that influenced Crow's arguments over the years as well as his scientific method. Crow has had a significant impact on the neuroscience of schizophrenia. Many of his observations are still valid and several questions he raised remain unanswered to date.https://www.cambridge.org/core/journals/psychological-medicine/article/seminal-contributions-of-timothy-j-crow/25B0EA70F496D0D3351937E44ADDD45
Evaluating Research Impact through Open Access to Scholarly Communication
No full textScientific research is a competitive business – in order to secure funding, promotion and tenure researchers must demonstrate their work has impact in their field. To maximise impact researchers undertake high priority research, aim to get results first, and publish in the highest impact journals. The Internet now presents a new opportunity to the scholarly author seeking higher impact: s/he can now make their work instantly accessible on the Web through author self-archiving. This growing body of open access literature (coupled with new publishing models that make journals available for-free to the reader) maximises research impact by maximising the number of people who can read it, and making it available sooner. Open access also provides a new opportunity for bibliometric research. This thesis describes the relatively recent phenomenon of open access to research literature, tools that were built to collect and analyse that literature, and the results of analyses of the effect of open access and its effect on author behaviour. It shows that articles self-archived by authors receive between 50-250% more citations, that rapid pre-printing on the Web has dramatically reduced the peak citation rate from over a year to virtually instant and how citation-impact – now widely used for evaluation – can be expanded to include a new web metric of download impact
The Gospel on the Margins: The Ideological Function of the Patristic Tradition on the Evangelist Mark
No full textIn spite of the virtually unanimous patristic opinion that the evangelist Mark was the interpreter of Peter, one of the most prestigious apostolic founding figures in Christian memory, the Gospel of Mark was mostly neglected in the patristic period. Not only is the text of Mark the least well represented of the canonical Gospels in terms of the number of patristic citations, commentaries and manuscripts, the explicit comments about the evangelist Mark reveal some ambivalence about its literary or theological value. In my survey of the reception of Mark from Papias of Hierapolis until Clement of Alexandria, I will argue that the reason why the patristic writers were hesitant to embrace the Gospel of Mark was that they perceived the text to be amenable to the Christological beliefs and social praxis of rival Christian factions. The patristic tradition about Mark may have little historical basis, but it had an important ideological function in appropriating the text in the name of an apostolic authority from the margins or periphery
Music for classical guitar by South African composers : a historical survey, notes on selected works and a general catalogue
No full textIncludes abstract.Includes bibliographical references (leaves 296-309).This is the first comprehensive investigation of music for, or including, the classical guitar by South African composers. The focus of this research has been, firstly, to uncover as much of the repertoire as possible, and, secondly, to collate, study, catalogue and report on the information. A brief historical survey of the guitar in South Africa provides the context within which this study was conducted. The primary sources of quantitative data collection were through the archival catalogues of the South African Music Rights Organisation and through personal contact with guitarists, composers and guitar teachers. Other sources consulted were publishers, broadcasting corporations, recording companies, libraries and the internet. The body of the dissertation comprises biographical sketches, background notes, analyses and technical notes on 17 selected solo and chamber works dating from 1947 to 2007 by some of South Africa's most prominent composers and guitaristcomposers. The repertoire ranges in style from the traditional and ethnically inspired to the experimental and abstract. As this is an empirical survey, each selected entry includes details on instrumentation, duration, level of difficulty, number of pages, scordatura, commissions or requests, sources or publishers, premières and recordings. A biography of each composer is provided as well as background notes which offer an overview of the selected work. The notes discuss historical, cultural, musical and extra-musical influences, and frequently include references to interview material. The commentaries on the selected works, with musical examples, include an analytical component describing structure, form, stylistic and compositional elements, while the technical observations include performance suggestions and a grading for each work
Using whole exome sequencing to investigate the genetic bases of lysosomal storage diseases of unknown etiology
No full textLysosomes are membrane-bound, acidic eukaryotic cellular organelles that play important roles in the degradation of macromolecules. Mutations that cause the loss of lysosomal protein function can lead to a group of disorders categorized as the lysosomal storage diseases (LSDs). Suspicion of LSD is frequently based on clinical and pathologic findings, but in some cases, the underlying genetic and biochemical defects remain unknown. Here, we performed whole exome sequencing (WES) on 14 suspected LSD cases to evaluate the feasibility of using WES for identifying causal mutations. By examining 2,157 candidate genes potentially associated with lysosomal function, we identified eight variants in five genes as candidate disease-causing variants in four individuals. These included both known and novel mutations. Variants were corroborated by targeted sequencing and, when possible, functional assays. In addition, we identified nonsense mutations in two individuals in genes that are not known to have lysosomal function. However, mutations in these genes could have resulted in phenotypes that were diagnosed as LSDs. This study demonstrates that WES can be used to identify causal mutations in suspected LSD cases. We also demonstrate cases where a confounding clinical phenotype may potentially reflect more than one lysosomal protein defect.Peer reviewe
The People Believe That He Has Risen from the Dead : The Gospel of Peter and Early Christian Apologetics
No full textNo scholarly consensus has been reached on the question of the relationship between the Gospel of Peter and the New Testament gospels. The same can be said about determining the particular factors that influenced the author of the noncanonical text when composing his own work. This dissertation contends that the author of the Gospel of Peter used all four canonical gospels as sources and that the category of Second Temple Jewish literature known today as Rewritten Bible provides the best analogue for understanding the manner in which the New Testament accounts have been reworked in the noncanonical gospel. Apologetic and polemical concerns are identified as significant influences on this work, and this dissertation considers the role of those outside the Christian movement in the formation of gospel traditions.
In Chapter Two it is determined that the most significant alteration to the Passion Narrative in the Gospel of Peter concerns the identity of those who crucify Jesus. Chapter Three examines the four signs at the crucifixion (i.e., darkness, torn veil, earthquake, the destruction of Jerusalem), noting how their role in the noncanonical text differs from the New Testament versions. The variations between the guard stories in Matthew and the Gospel of Peter are reviewed in Chapter Four, and it is claimed that these differences are due to apologetically motivated redaction. Unlike the New Testament gospels, the Gospel of Peter includes an account of Jesus emerging from the tomb, and reasons for this are explored in Chapter Five. The final chapter examines two features of the extra-canonical text: the women\u27s fear of the Jews during their visit to the tomb, and the role of Peter as the narrator of this gospel.
In each of these final five chapters, after demonstrating the specific way(s) that the New Testament accounts have been retold in the Gospel of Peter, this study surveys similar examples from other early Christian literature in order to situate this gospel within a particular socio-religious context. In the last section of each chapter, an explanation is offered as to why the noncanonical author has changed the story in the manner(s) proposed
The man unmasked: or, The world undeceived, [electronic resource] : in the author of a late pamphlet, intitled, "Extracts from the proceedings of the High Court of Vice-Admiralty in Charlestown, South-Carolina," &c. With suitable remarks on that masterly performance. By Egerton Leigh. [Seven lines of quotation].
No full textHenry Laurens, in the anonymously published Extracts of the proceedings .. (Philadelphia, 1768 and Charleston, 1769), charged Leigh with misconduct in his position as judge of the Court of Vice-Admiralty.Errata note, p. [17], 3rd count.Signatures: [A]p4s B-2Dp4s (D4 verso blank; H1 missigned G)Evans,Electronic reproduction.English Short Title Catalog,Reproduction of original from Library of Congress
AN ANALYSIS OF VOCAL STEREOTYPY AND THERAPIST FADING
No full textA functional analysis for a boy with Down syndrome and autism suggested that vocal stereotypy was maintained by automatic reinforcement. The analysis also showed that instructions and noncontingent attention suppressed vocal stereotypy. A treatment package consisting of noncontingent attention, contingent demands, and response cost effectively reduced vocal stereotypy. The treatment package remained effective even when noncontingent attention was removed, making the procedure easier to implement. Also, the presence of the therapist in the room with the participant was faded systematically. After completion of fading, vocal stereotypy remained low during conditions similar to the no‐consequence phase of the functional analysis.Peer reviewedFinal article publishedAutismDown syndromeResponse costTreatment fadingVocal stereotyp
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
No full textThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
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