1,722,092 research outputs found
C. Caprino, A. M. Colini, G. Gatti, M. Pallottino, P. Romanelli, La colonna di Marco Aurelio
No full textD. S. G. M. C. Caprino, A. M. Colini, G. Gatti, M. Pallottino, P. Romanelli, La colonna di Marco Aurelio. In: Bulletin de l'Association Guillaume Budé, n°2, juin 1957. pp. 99-100
Feasibility of FreeStyle Libre Flash Glucose Monitoring System in pregnant woman affected by type 1 diabetes
No full textN
Pharmacokinetic analysis investigating gentamicin dosing in a major burned patient complicated by septic shock
No full textProfound pharmacokinetic alterations involving volume of distribution and clearance may impair the achievement of adequate antimicrobial serum concentrations in major burn patients. Gentamicin pharmacokinetic analysis was performed in a major burn victim with 90% of total body surface area affected and complicated by septic shock due to Serratia marcescens (minimum inhibitory concentration [MIC] = 2 mg/L). Gentamicin 240 mg was administered as a 30-min intravenous infusion, and plasma samples were obtained at 0-, 0.5-, 1-, 3- and 6-hour time points after the start of infusion. Gentamicin peak concentrations (CMAX) were 11.9 mg/L, providing for the achievement of an inadequate CMAX/MIC target. Volume of distribution was more than double as compared to healthy volunteers (0.44 vs. 0.18 L/Kg), while clearance was quite similar (5.21 vs. 5.42 L/h). Higher dosage (7–10 mg/Kg) coupled with adaptive therapeutic drug monitoring should be implemented in order to maximize gentamicin dosing schedule in critical challenging situations
Relation between dynamic amplification, structural height and damage in buildings affected by the recent Italian earthquakes
No full textTo exploit the purely geometric link between the elastic period of vibration T and the height H (or number of stories) of a building, T was varied from 0 to 0.5 s coinciding with a height between 0 and 12 m (at most the four stories typical of Italian buildings) in order to estimate the spectral accelerations corresponding to acceleration measurements recorded during the earthquakes of L’Aquila, Emilia and central Italy. These estimates were used to calculate the maximum dynamic amplification factors and corresponding heights, called critical heights, that can generate either resonance or appreciable dynamic amplification values. The results showed dynamic amplification values close to 3 for reinforced concrete buildings and 2.5 for masonry buildings independently of the characteristics of the earthquakes. There was a significant coincidence between the structural height of the buildings with greatest recorded damage and the critical height. The basis of the study lies in simple numerical steps carried out with easily obtainable data: for this reason, it can be easily applied to determine the vulnerability of a building according to its structural height
A new simple medium for the detection of Enterococcus faecalis and Enterococcus faecium by measurement of conductance changes
No full textA new simple medium for the detection of strains from the Enterococcus species by conductivity measurement was developed and evaluated using the Malthus‐AT system. The analysis repeatability was shown, and the presence of 1 cfu ml‐1 in pure culture was detected within 16 h. The selectivity of the medium was tested using the most common species which are found, in association with microorganisms from the Enterococcus species, in food products and water. Copyright © 1993, Wiley Blackwell. All rights reserve
La distribuzione del settore farmaceutico: evoluzioni strutturali dell'intermediazione e ruolo del grossista
No full textAntimicrobial Dose Reduction in Continuous Renal Replacement Therapy: Myth or Real Need? A Practical Approach for Guiding Dose Optimization of Novel Antibiotics
Full text linkAcute kidney injury represents a common complication in critically ill patients affected by septic shock and in many cases continuous renal replacement therapy (CRRT) may be required. In this scenario, antimicrobial dose optimization is highly challenging as the extracorporeal circuit may cause several pharmacokinetic alterations, which add up to volume of distribution and clearance variations resulting from sepsis. Variations in CRRT settings (i.e. modality of solute removal, type of filter material, blood flow rate and effluent flow rate), coupled with the presence of residual and/or recovering renal function, may cause dynamic variations in the clearance of hydrophilic antimicrobials. This means that dose reduction may not always be needed. Nowadays, the lack of pharmacokinetic data for novel antimicrobials during CRRT limits evidence-based dose recommendations for critically ill patients in this setting, thus making available evidence hardly applicable in real-world scenarios. This review aims to summarize the major determinants involved in antimicrobial clearance, and the available pharmacokinetic studies performed during CRRT involving novel antibiotics used for the management of multidrug-resistant Gram-positive and Gram-negative infections (namely ceftolozane–tazobactam, ceftazidime–avibactam, cefiderocol, imipenem–relebactam, meropenem–vaborbactam, ceftaroline, ceftobiprole, dalbavancin, and fosfomycin), providing a practical approach in guiding dose optimization in this special population
Death by a Thousand Cuts: Hostile Bids in Europe, 2004-2023
No full textThe E.U. Takeover Directive was passed twenty years ago with the main aim of fostering a single European takeover market. However, subsequent economic, political, legal, and corporate governance developments have hindered the Directive’s goal of enhancing the European market for corporate control. This paper outlines the pro-market climate surrounding the Directive’s inception, traces the subsequent changes in market dynamics and governance, and examines the legislative measures that have contributed to the current state of the market for corporate control in Europe. Despite the continued existence of hostile bids, their importance and impact has shrunk under the current environment. This trend has reduced firm dynamism and resulted in benefits for a select few (notably, corporate insiders and national politicians)
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