1,721,002 research outputs found
Le emissioni di CO2eq provocate dalla pubblicazione di un libro. La compensazione attraverso la scelta delle specie arboree idonee
No full textDa quanto emerge dall’ultimo rapporto sul clima effettuato dall’IPCC (Intergovernmental Panel on Climate Change) nel 2014, l’influenza dell’uomo sul cambiamento climatico è evidente, e le concentrazioni di gas serra attuali sono senza precedenti, almeno negli ultimi 800.000 anni. Con una temperatura globale superiore di 0,97°C alla media (considerando sia la temperatura terrestre che quella ocenica), i primi dieci mesi del 2016 (l'anno più caldo degli ultimi 137 anni) sono da primato, in confronto ai +0,87°C dei primi dieci mesi del 2015. Mai, almeno nei tempi recenti, una simile variazione è avvenuta in così breve tempo. E nessuno dei meccanismi naturali sembra in grado di spiegare un simile riscaldamento (Greenpeace).
Abbiamo, però, la possibilità di conoscere ed evitare tali impatti e, se proprio non ci riusciamo, possiamo mitigarli o, infine, compensarli. Questo lavoro svolto sulla compensazione delle emissioni prodotte per la stampa di un libro, è un esempio di come si può agire su piccola scala e con effetti positivi sul territorio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
LOH as "the missing instability" potentially underlying the tumor immunogenicity: On the trails of a correlation between fractional allelic loss and response to nivolumab in renal cancer
No full textAim/Background: Microsatellite instable (MSI) phenotype characterizes tumors with high mutational load, encoding immunogenic neoantigens correlated with susceptibility to immune-checkpoint inhibitors (CKI). MSI is rare (3-4%) in renal cell carcinoma (RCC), although CKI are effective in a significant fraction of advanced tumors. We evaluated the hypothesis that loss of heterozygosity (LOH) of relevant tumor suppressor genes (TSG) might provide a measure of tumor immunogenicity, contributing as “the missing instability” to a high fractional allele loss (FAL) potentially underlying the rate of disease control obtained with CKI. We preliminary report the possible predictive value of LOH at different loci on 3p in patients with advanced RCC treated with the anti-PD-1 nivolumab.
Methods: After DNA extraction from FFPE tissues of nephrectomy specimens, LOH study was performed by PCR for the microsatellite markers D3S1481 (3p14.2, FHIT gene) and D3S1478 (3p21.3-21.2). Non-informative (NI) cases due to homozygosity were subsequently tested for D3S1621 (3p21.2, LCTSGR1 gene). MSI was assessed using two classical mononucleotide markers, BAT-25 and BAT-26.
Results: Nine RCC cases evaluable for response were analyzed. All were microsatellite stable (MSS). Five cases (45%) had LOH: 3 only at the FHIT locus (D3S1481), 2 at both D3S1481 and D3S1478 loci. All these patients with LOH of at least one 3p locus had good disease control and clinical benefit with nivolumab (2 had partial response and 3 stable disease, SD). The remaining 4 cases were negative for LOH at the informative loci: 3 of them were clearly non-responsive to nivolumab (confirmed progression disease) and one had SD.
Conclusions: These preliminary results suggest that LOH at 3p loci correlates with good disease control with nivolumab in advanced RCC patients. Our findings support the hypothesis that LOH at relevant genetic loci may provide a measure of mutational burden and of tumor immunogenicity and it could be used as predictive biomarker of response to CKI. Further analyses are planned with the aim to investigate other loci of key-TSG on 3p, 9p and 14p, evaluating the FAL index as potential more reliable predictive factor
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Epidermal growth factor receptor gene in fine needle aspirates from metastatic sites of non-small cell lung cancer
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