1,355,674 research outputs found
Fuoco grande di Pavese e Garufi
No full textFuoco grande di Cesare Pavese e Bianca Garufi, pubblicato nel 1959, dopo la morte di Pavese, rientra nel genere della scrittura a quattro mani. Fu composto dai due scrittori nei primi mesi del 1946 e si interruppe all’undicesimo capitolo: se ne venne a conoscenza perché fu ritrovato, dopo la sua morte, tra le carte di Pavese. Il racconto procede a capitoli alterni, uno scritto da Pavese e uno dalla Garufi: Pavese segue la vicenda dal punto di vista del protagonista maschile, Giovanni; la Garufi fa altrettanto dal punto di vista della protagonista femminile, Silvia
Data Archiving and Distribution of the Virgo Antenna for Gravitational Wave Detection
No full textWe describe the architecture of the data archiving and distribution of the Virgo antenna for gravitational wave detection. The main characteristic of this system is the modularity of the architecture. This solution allows system upgrades without dramatic changes of the hardware and software components. The main performances are: 1. Maximum sustained data flow of 10 Mbyte/s on DLT tapes (35/70 Gbyte) for the raw data archiving; 2. Up to 1 Tbyte data archiving capacity on disk at a maximum sustained data flow of 25 Mbyte/s for the online data distribution; 3. Up to 10 Mbyte/s data retrieval flow for the on-line data distribution. The basic architecture of the system consists of two sections: an acquisition and storage section and a data management section. The former is a LynxOS based system with the disks directly connected to the CPU slave boards, the latter is a DEC-Unix Alpha Server (Data Server), NFS mounting the LynxOS disks through a Fast Ethernet networ
Bianca Garufi: the virtue of curiosity
No full textIn this article the importance of Bianca Garufi in the Italian cultural milieu is presented and discussed. Her view of the world and of the psyche always emphasised the fundamental role of the relationships between the various psychic components within a non-reducible monotheism as well as a tendency to avoid definitive explanations. The research on the image that Garufi carried out throughout her life is proof of these attitudes. For her, the image is crucial not only because of its intrinsic unity but also because of its role in the imaginative process and because it is the engine of psychological development. Bianca Garufi established and maintained important links between the Italian and English analytical worlds, and also made a considerable contribution to the development of the archetypal school of thought, especially by translating into Italian and disseminating the works of James Hillman.</jats:p
Bianca Garufi, la scrittrice femminista amata da Cesare Pavese
No full textIl contributo esamina la produzione di Bianca Garufi (1918-2006), narratrice,
poetessa, psicologa italiana, fino ad oggi esclusivamente nota per la sua
relazione amorosa con Cesare Pavese e per il romanzo Fuoco grande, con
lui scritto a quattro mani. La qualità della sua produzione letteraria merita
un’attenzione monografica, che possa valorizzare il contributo che Bianca
Garufi ha dato all’emancipazione letteraria femminile.
Parole chiave: poesia, letteratura, femminismo, mito, psicologia
High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity
No full textBACKGROUND:
In response to diverse genotoxic stimuli p53 is activated as transcription factor to exert its tumor-suppressor function. P53 activation requires protein stabilization, nuclear localization and posttranslational modifications in key residues that may influence p53 selection of target genes. Among them, serine 46 (Ser46) phosphorylation is considered specific for apoptotic activation. Hyperglicaemia, the high blood glucose condition, may negatively affect tumor response to therapies through several mechanisms, conferring resistance to drug-induced cell death. However, whether high glucose might modify p53Ser46 phosphorylation has never been addressed.
METHODS AND RESULTS:
Here, we performed biochemical and molecular analyses in different cancer cell lines treated with chemotherapy in the presence or absence of high glucose condition. Analyses of p53 posttranslational modifications showed that drug-induced p53Ser46 phosphorylation was reduced by high glucose. Such reduction depended by high glucose-induced calyculin A-sensitive phosphatase(s), able to specifically target p53Ser46 phosphorylation. The specific effect on Ser46 phosphorylation was addressed by analysing Ser15 phosphorylation that instead was not modified by high glucose. In agreement, a constitutively phosphorylated Ser46D p53 mutant was resistant to high glucose. As a consequence of phosphoSer46 impairment, high glucose reduced the tumor cell response to drugs, correlating with reduced p53 apoptotic transactivation. The drug-induced apoptotic cell death, reduced by high glucose, was finally restored by the phosphatase inhibitor calyculin A.
CONCLUSIONS:
These data indicate that high glucose specifically inhibited Ser46 phosphorylation thus reducing p53 apoptotic activity. These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular link between metabolic diseases such as diabetes or obesity and tumor progression and resistance to therapies
Transparency and exchange of information in international taxation
No full textDescriptionContentsResourcesAbout the Authors
While its importance in domestic law has long been acknowledged, transparency has until now remained largely unexplored in international law. This study of transparency issues in key areas such as international economic law, environmental law, human rights law and humanitarian law brings together new and important insights on this pressing issue. Contributors explore the framing and content of transparency in their respective fields with regard to proceedings, institutions, law-making processes and legal culture, and a selection of cross-cutting essays completes the study by examining transparency in international law-making and adjudication.
contains: 3 b/w illus. 7 table
The search for Gravitational Waves: Status and perspectives
No full textIn this paper we give an overview of the present status and future perspectives of the search for gravitational waves. Gravitational Waves (GW) are predicted by the General Theory of the Relativity and, due to their very weak interaction with matter, can be an invaluable tool to look to the universe up to its very first moments. On the other hand, these same characteristics make their detection very difficult to achieve, and, at present, we have only indirect proof of their existence. In the last years the techniques adopted to directly detect GWs converged to laser interferometers. A world network of kilometer-scale laser interferometers is presently taking data but their sensitivity does not seem enough to give results in reasonable times. To this purpose all the presently working interferometers have plans to enhancement in the next few years and second-generation detectors, both ground and space based, are already in the design phase
A novel Zn(II)-compound reactivates mutant p53 protein in cancer cells: molecular mechanisms and therapeutical implications
No full textNuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity
No full textResistance to chemotherapy represents a major hurdle to successful cancer treatment. A key role for efficient response to anticancer therapies is played by TP53 oncosuppressor gene that indeed is mutated in 50% of human cancers or inactivated at protein level in the remaining 50%. Homeodomain-interacting protein kinase 2 (HIPK2) is the wild-type p53 (wtp53) apoptotic activator, and its inhibition by hypoxia or hyperglycemia may contribute to tumor chemoresistance mainly by impairing p53 apoptotic activity. Another important molecule able to induce chemoresistance is nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) transcription factor, whose activation by oxidative and/or electrophilic stress regulates a transcriptional antioxidant program allowing cancer cells to adapt and survive to stresses. NRF2 may shift from cytoprotective to tumor-promoting function, according to tumor phases. NRF2 may crosstalk with both wtp53 and mutant p53 (mutp53), inhibiting the wtp53 apoptotic function and strengthening the mutp53 oncogenic function. NRF2 has also been shown to induce HIPK2 mRNA expression cooperating in inducing cytoprotection. Although HIPK2, p53, and NRF2 have been individually extensively studied, their interplay has not been clearly addressed yet. On the basis of the background and our results, we aim at hypothesizing the unexpected pro-survival activity played by the NRF2/HIPK2/p53 interplay that can be hijacked by cancer cells to bypass drugs cytotoxicity
A Michelson interferometer for seismic wave measurement: theoretical analysis and system performances
No full textAbstract
This papers describes a new low-frequency seismic sensor for geophysical applications. The instrument is basically a monolithic tunable folded pendulum with an interferometric readout system, that can be configured as seismometer or as accelerometer. The monolithic mechanical design and the introduction of a laser interferometric technique for the readout implementation make it a very sensitive and compact instrument with a very good immunity to environmental noises. Preliminary tests on the mechanical performances of the monolithic structure and on the optical reaodut have been performed. Interesting result is the measured resonant frequency of the instrument of ≈ 150 mHz obtained with a rough tuning, demonstrating the feasibility of a resonant frequency of the order of 5 mHz with a more refined tuning. The mechanics of the seismic sensor, the optical scheme of the readout system, the theoretical predictions and the preliminary experimental performances as seismometer are discussed in detail, together with the foreseen further improvements
- …
