52,048 research outputs found
The Pacific lineage (2E) of JC polyomavirus is prevalent in Sumba Island, Eastern Indonesia
Get PDFRecent studies have identified a Pacific lineage (2E) of JC polyomavirus (also designated as JC virus or JCV) that occurs in both Island Southeast Asia and Oceania, but not in mainland Asia. It has been postulated that this lineage traveled with Austronesian-speaking people who are now spread throughout Island Southeast Asia and Oceania (excluding Australia and inland and southern New Guinea). However, to date, the 2E lineage has been identified in Southeast Asia only in populations of the Philippine islands. Here we report that a high incidence of the 2E lineage was detected in the people of Sumba Island, eastern Indonesia
Erratum : Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome (Journal of Clinical Endocrinology and Metabolism (2019) 104: 2 (595–603) DOI: 10.1210/jc.2018-01197)
No full textPublisher Copyright: Copyright © 2019 Endocrine Society.In the above-named article by Tapia-Castillo A, Baudrand R, Vaidya A, Campino C, Allende F, Valdivia C, Vecchiola A, Lagos CF, Fuentes CA, Solari S, Martinez-Aguayo A, Garcia H, Carvajal CA, and Fardella CE (J Clin Endocrinol Metab. 2019;104(2):595-603; doi: 10.1210/jc.2018-01197) the following error occurred in the author line: the affiliation numbers for Carlos F. Lagos and Sandra Solari were incorrect
Erratum : Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome (Journal of Clinical Endocrinology and Metabolism (2019) 104: 2 (595–603) DOI: 10.1210/jc.2018-01197)
No full textPublisher Copyright: Copyright © 2019 Endocrine Society.In the above-named article by Tapia-Castillo A, Baudrand R, Vaidya A, Campino C, Allende F, Valdivia C, Vecchiola A, Lagos CF, Fuentes CA, Solari S, Martinez-Aguayo A, Garcia H, Carvajal CA, and Fardella CE (J Clin Endocrinol Metab. 2019;104(2):595-603; doi: 10.1210/jc.2018-01197) the following error occurred in the author line: the affiliation numbers for Carlos F. Lagos and Sandra Solari were incorrect
JC virus evolution and its association with human populations
Get PDFThe ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children. There are at least 14 subtypes of the virus associated with different human populations. Because of its presumed codivergence with humans, JCV has been used as a genetic marker for human evolution and migration. Codivergence has also been used as a basis for estimating the rate of nucleotide substitution in JCV. We tested the hypothesis of host-virus codivergence by (i) performing a reconciliation analysis of phylogenetic trees of human and JCV populations and (ii) providing the first estimate of the evolutionary rate of JCV that is independent from the assumption of codivergence. Strikingly, our comparisons of JCV and human phylogenies provided no evidence for codivergence, suggesting that this virus should not be used as a marker for human population history. Further, while the estimated nucleotide substitution rate of JCV has large confidence intervals due to limited sampling, our analysis suggests that this virus may evolve nearly two orders of magnitude faster than predicted under the codivergence hypothesis.</p
Correlation of the success index with JC.
No full text<p>Pearson’s r and p-value.</p><p>*: p-value below smallest representable number</p><p>Correlation of the success index with JC.</p
MITIN. Polideportivo Rondilla. Domingo, 8 de junio, 12,30 horas. JUAN COLINO SALAMANCA. J.C. NALDA-GARCIA ANTONIO PEREZ SOLANO GREGORIO PECES-BARBA.
No full textPoster promoting a rally featuring Juan Colino Salamanca, JC Nalda-Garcia, Antonio Perez Solano, and Gregorio Peces-Barba
An R Package for Assessing Drug Synergism/Antagonism
Get PDFSynergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and Talalay (1984) for estimating drug interaction indices. One advantage of the MixLow method is that the nonlinear mixed-effects model used to estimate parameters of concentration-response curves can provide more accurate parameter estimates than the log linearization and least-squares analysis used in the Median-Effect method. This paper introduces the mixlow package in R, an implementation of the MixLow method. Results are reported for a small simulation study.
PBBCache: an open-source parallel simulator for rapid prototyping and evaluation of cache partitioning and cache-clustering policies
No full text© 2020 Elsevier B.V. All rights reserved
We thank the anonymous reviewers for their invaluable feedback. This work has been supported by the EU (FEDER), the Spanish MINECO and CM, under grants TIN 2015-65277-R,RTI2018 093684-B-I00 and S2018/TCS-4423. Adrian Garcia-Garcia is supported by a UCM fellowship grant.Ministerio de Economía y Competitividad (España)European UnionDepto. de Arquitectura de Computadores y AutomáticaFac. de InformáticaTRUEpu
Mitotracker Green and JC-1 staining.
No full text<p>Epifluorescence photomicrography of the staining of embryos at 90 hpi: A) blastomeres stained in green = membrane potential detected via staining with Mitotracker Green; B) blastomeres stained in red = membrane potential detected via staining with JC-1; and C) blastomeres stained in green = the absence of membrane potential detected via staining with JC-1.</p
Evaluation with in vivo optical coherence tomography and histology of the vascular effects of the everolimus-eluting bioresorbable vascular scaffold at two years following implantation in a healthy porcine coronary artery model: implications of pilot results for future pre-clinical studies.
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