24,711 research outputs found
Conversando con... Kathryn Gustafson
No full text[EN] Kathryn Gustafson is an internationally recognized landscape architect. Intially trained in art and fashion design, she later studied landscape architecture at the École de Paysage de Versailles in France. Here she developed her early work in this country, exemplified by the magical Les Jardins de l ́Immaginaire.She is presently engaged in landscape practice through two two different practices: Gustafson Porter, based in London, and Gustafson Guthrie Nicol, based in Seattle. Workin with her colleagues at these firms, relevant works include Westergasfabriek Cultural Park in Amsterdam, the Lurie Garden at the Millenium Park in Chicago, the Princess Diana Memorial in Hyde Park, the first ever landscape installation at the 11th Architecture Biennale in Venice and the winning design of Unified Ground: Union Square for the National Mall Competition in Washington, DC.Kathryn Gustafson ́s work has been widely published internationally and has obtained an astonishing number of awards and recognitions. For her significant contribution to architecture and art, she was the first landscape architect to be awarded the Arnold W. Brunner Memorial Prize in Architecture from the American Academy of Arts and Letters in 2012. In 2014 she won the Obayashi Prize, and in 2015 she received an honorary doctorate from the Polytechnic University of Valencia in Spain.Kathryn Gustafson has always had a personal voice in contemporary landscape architecture, which remains relevant, innovative and meaningful. This voice stands out for the way it deals terrain modeling in her projects. This sculptural and sensual modeling can be seen in the Central Park Valencia, a project that is the result of an international competition in which Gustafson Porter, along with Nova, Grupotec Engineering and Borgos Pieper architects, won the first prize, supported by widespread acclaim for her proposal.[ES] Kathryn Gustafson es una paisajista norteamericana reconocida a nivel internacional. Tras estudiar arte y diseño de moda, se formó como paisajista en Francia, en la Escuela de Versalles. En este país realizó sus primeras obras, entre las que destacan los mágicos Jardines de L´Immaginaire. Actualmente, Kathryn Gustafson desarrolla su práctica profesional a través de dos estudios diferentes: Gustafson Porter, afincado en Londres, y Gustafson Nicol Guthrie, con oficinas en Seattle. Entre sus obras más relevantes podemos citar el parque cultural de la Westergasfabriek en Amsterdam o el Lurie Garden, en el Millenium Park de Chicago, el memorial de la princesa Diana en Hyde Park, su propuesta para la 11ª Bienal de Venecia y el proyecto ganador del concurso para Union Square, en el National Mall de Washington.La obra de Kathryn Gustafson ha sido ampliamente publicada internacionalmente, y ha obtenido un número impresionante de premios y distinciones. Algunos de los más recientes son el Arnold Brunner Memorial Prize in Architecture de 2012, de la Academia Americana de Artes y Letras, en reconocimiento a su contribución a la arquitectura como arte, y el premio Obayashi en 2014. Kathryn Gustafson recibió en 2015 un Doctorado Honoris Causa por la Universitad Politècnica de València.Kathryn Gustafson ha tenido siempre una voz propia dentro del paisajismo contemporáneo, una voz relevante, innovadora y significativa en muchos aspectos. Esta voz destaca, especialmente, por la forma en que aborda el modelado del terreno en sus proyectos, un modelado escultural y sensual, que podemos apreciar también en su proyecto para el Parque Central de Valencia, un proyecto que surge como resultado de un concurso internacional, en el que Gustafson Porter, junto con las Ingenierías Nova y Grupotec y el estudio Borgos Pieper, presentó una propuesta que recibió el primer premio, suscitando después una opinión favorable absolutamente unánime.Pérez Igualada, J. (2017). Conversando con... Kathryn Gustafson. EGA. Revista de Expresión Gráfica Arquitectónica. 22(29):12-27. https://doi.org/10.4995/ega.2017.7346SWORD1227222
Oxygenation studies of Bis(O-ethyl-L-cysteinato)nickel(II) /by Samantha Jane Gustafson.
No full textSulfur-rich zinc sites are common motifs used in biological systems; the most notable are the zinc binding sites of zinc fingers, which play vital roles in controlling cellular functions such as transcription, translation, DNA repair, and apoptosis. Replacement of Zn with Ni can cause serious health problems. Model compounds are used to better understand the mechanism of exchange and the changes that the displacement has on the structure and the chemical reactivity._x000D_Zinc centers in proteins typically show no susceptibility to reactivity with oxygen. However, replacement of Zn with Ni increases the chances of oxidative damage, which results in toxicity. Bis(O-ethyl-L-cysteinato)nickel(II), Ni(cysE)2, was used to model O2 reactivity of proteins in which Zn has been replaced with Ni. Reactions of Ni(cysE)2 with O2 resulted in both oxygenation of the sulfurs as well as oxidation of the thiolate sulfur from a disulfide. The UV-vis data show formation of a trimetallic species [Ni(Ni(cysE)2)2]2+ . IR data show the formation of a monosulfone, and the mass spectrometry data indicate the formation of a thiolsulfinate and an octahedral species Ni(cysE)3
Syndioselective MMA Polymerization by Group 4 Constrained Geometry Catalysts: A Combined Experimental and Theoretical Study
No full textThis contribution reports a combined experimental (with kinetics and tangible effects on
syndioselectivity) and theoretical (with density functional theory) study of (CGC)M catalysts [M ) Ti, Zr; CGC
) Me2Si(η5-Me4C5)(tBuN)], addressing a need for a fundamental understanding of the stereoselectivity observed
for such catalysts in polymerization of methyl methacrylate (MMA) and an explanation for the chain-end control
nature of the syndioselective MMA polymerization by the chiral (CGC)Ti catalyst. The living/controlled MMA
polymerization by (CGC)TiMe+MeB(C6F5)3
- (1) follows the zero-order kinetics in [MMA], implying a faster
ring-opening process of the cyclic chelate relative to MMA addition within the catalyst-monomer complex in a
unimetallic propagation cycle. The syndioselectivity of 1 is insensitive to monomer and catalyst concentrations
as well as to ion-pairing strength varied with counterion structure and solvent polarity. Comparative studies using
identical (CGC)M bis(isopropyl ester enolate) structures show that the (CGC)Ti system exhibits noticeably higher
syndioselectivity than the isostructural Zr system at ambient temperature. Density functional calculations rationalize
the higher syndioselectivity observed for the (CGC)Ti catalyst and lend a theoretical support for the mechanism
of MMA- or counterion-assisted catalyst site epimerization after a stereomistake, which accounts for the formation
of the predominately isolated m stereoerrors
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
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Development of Atroposelective Nucleophilic Substitutions Towards Pharmaceutically Relevant N-Heterocyclic Scaffolds
No full textAtropisomerism is a form of dynamic chirality arising from hindered bond rotation, most typically in a Csp2-Csp2 σ bond, in which the adjacent substitutions contribute energy differences caused by steric strain. While prevalent in many different molecules like natural products and catalysis, atropisomerism has largely been implicated in many important pharmaceuticals in drug discovery. While there has been interest in medicinal chemistry within these last two decades, there are many challenges to creating stable atropisomerism – in which there is significant steric strain to give rise to two isolable enantiomers.1 However, in stabilizing the atropisomeric axis towards these two enantiomers can lead to profound effects on target selectivity. Within the last decade, the Gustafson group at San Diego State University2–4 has since focused on leveraging atropisomerism5,6 to increase selectivity (and later potency) of promiscuous pharmaceutically relevant compounds. Particularly focused on kinase inhibitors, we have shown that curated designs of stable atropisomeric analogues were able to successfully “lock the molecule” in the most bioactive conformation and preorganize the molecules’ atropisomeric axes into preferred dihedral angles which bind to the kinase of interest.One of the major drawbacks to stable atropisomerism is the difficulties attributed to accessing enantiomerically pure samples. Traditional resolution methods like chiral separation (e.g., HPLC or SFC) can be inconducive in time and resources and sometimes impractical for scaffold exploration. For this reason, the Gustafson group began a marital chemistry program towards developing new chemical reactions that expedite access to these atropisomeric compounds. Finding effective atroposelective synthetic methods to obtain pharmaceutically relevant N-heterocyclic scaffolds has been a long-standing challenge in drug discovery. Further elaboration of this work was covered in our seminar reviews. Specific works from these reviews were highlighted in Chapter 17,8 that pertain to the research featured in this dissertation.
To address this limitation, we have developed several atroposelective synthetic strategies via nucleophilic substitutions. These are a class of reactions which are among the most widely used in medicinal chemistry towards ethers (i.e., C-O bonds), amines (i.e., C-N bonds), and sulfides (i.e., C-S bonds) towards pharmaceutically relevant N-heterocyclic scaffolds. I and my colleagues developed an atroposelective nucleophilic aromatic substitution (SNAr) strategy which was used in facile access towards pharmaceutically relevant 3-aryl pyrrolopyrimidines (PPYs) and 3-aryl quinolines. A thorough discussion of this atroposelective SNAr research is covered in Chapter 29,10 of this dissertation. Further studies to apply these synthetic strategies has found recent success, wherein post-functionalization after our subsequent atroposelective SNAr methods lead to compounds that have potential to be used for chemical probes, which is briefly discussed in Chapter 3.
Furthermore, nucleophilic substitutions outside of SNAr have also been widely used for the synthesis of pharmaceutically relevant compounds. Chapter 4 of this dissertation unveils other types of enantioselective functionalization of various N-heterocyclic scaffolds which sample other unique chemical space, such as enantioselective vicarious nucleophilic substitution (VNS) and atroposelective alkylation by acid-catalyzed directed ‘nucleophilic radicals’ (otherwise known as Minisci chemistry). While the findings shared are preliminary as the current enantioselectivity and yields are not yet optimal, it is quite promising and serves as a strong foundation for future pursuit of these new atroposelective nucleophilic substitution methodologies by the current Gustafson lab.
We firmly believe that this research will impact the current need for atroposelective nucleophilic substitution strategies towards pharmaceutically relevant scaffolds in the field of asymmetric catalysis. It is with hope to then springboard new developments in enantioselective reactions towards N-heterocyclic atropisomers relevant to drug discovery. Lastly, we shared that these chemistries furnished enantioenriched pharmaceutically relevant scaffolds in desired yields that would be useful to ongoing medicinal chemistry efforts
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Oxygenation studies of Bis(O-ethyl-L-cysteinato)nickel(II)
No full textSulfur-rich zinc sites are common motifs used in biological systems; the most notable are the zinc binding sites of zinc fingers, which play vital roles in controlling cellular functions such as transcription, translation, DNA repair, and apoptosis. Replacement of Zn with Ni can cause serious health problems. Model compounds are used to better understand the mechanism of exchange and the changes that the displacement has on the structure and the chemical reactivity. Zinc centers in proteins typically show no susceptibility to reactivity with oxygen. However, replacement of Zn with Ni increases the chances of oxidative damage, which results in toxicity. Bis(O-ethyl-L-cysteinato)nickel(II), Ni(cysE)2, was used to model O2 reactivity of proteins in which Zn has been replaced with Ni. Reactions of Ni(cysE)2 with O2 resulted in both oxygenation of the sulfurs as well as oxidation of the thiolate sulfur from a disulfide. The UV-vis data show formation of a trimetallic species [Ni(Ni(cysE)2)2]2+ . IR data show the formation of a monosulfone, and the mass spectrometry data indicate the formation of a thiolsulfinate and an octahedral species Ni(cysE)3.illustrations (some color)Includes bibliographical references
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
O. A. C. Review Volume L Issue 5, February 1938
No full textThis issue begins with an article about the history of Red Fife Wheat from its origins in Galicia to its importation to Peterborough. Agricultural articles pertain to the dietary benefits of human consumption of rye and timothy grasses, and continued research in soil nutrient depletion. Other articles include the presentation of A. T. Christie's Victorian medals to the Ontario Agricultural College. An alumnus continues his 1931 story as a stowaway. The English column addresses the use of proper English and the origin of the Little Theatre Movement. While the literary column provides book reviews, an account of the Canadian Author Lecture by H. Napier Moore, and the composition of epitaphs. The athletics column reports on the results of the competitions in basketball, swimming, hockey, boxing, wrestling, and fencing. In the Macdonald Institute column a student describes the O. A. C. campus to foreign students, there are also accounts of the "Feminine Section of O. A. C., and a tally of the food consumed in the dinning hall. The highlight of the campus news column is the Conversazione of 1938 and the social events of the season. The O. V. C. column provides updates of the joint social events between the colleges on campus. A new column - the Club News, reviews events for each of the animal husbandry, field husbandry, dairy, horticulture, and biology clubs. Alumni and Alumnae columns provide alumni updates.EditorialLand of the first Red Fife kernelA. T. (Dad) Christie gives keepsakes to President of farm collegeSo now we eat grassStowaway voyageChemistry department attacks soil depletionDepartment of English bulletinThe Origin of the Little Theatre MovementO. A. C. sportsfolioLiterary highlightsMacdonald newsThis life of oursCollege lifeConversazioneHands across the highwayClub newsAlumni newsMacdonald alumnaeGraduate newsadvertisin
Political life writing in the Pacific
No full textThis book aims to reflect on the experiential side of writing political lives in the Pacific region. The collection touches on aspects of the life writing art that are particularly pertinent to political figures: public perception and ideology; identifying important political successes and policy initiatives; grappling with issues like corruption and age-old political science questions about leadership and ‘dirty hands’. These are general themes but they take on a particular significance in the Pacific context and so the contributions explore these themes in relation to patterns of colonisation and the memory of independence; issues elliptically captured by terms like ‘culture’ and ‘tradition’; the nature of ‘self’ presented in Pacific life writing; and the tendency for many of these texts to be written by ‘outsiders’, or at least the increasingly contested nature of what that term means
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