1,720,967 research outputs found
Papillary serous carcinoma of ovarian type of the testis with borderline differentiation.
No full textCell counting and three-dimensional reconstruction identify a cellular wave in human spermatogenesis.
No full textA quantitative approach to the classification of hypospermatogenesis in testicular biopsies for infertility.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
AN IMMUNOHISTOCHEMICAL STUDY OF MORULES IN ENDOMETRIOID LESIONS OF THE FEMALE GENITAL TRACT: CD10 IS A CHARACTERISTIC MARKER OF MORULAR METAPLASIA.
No full textPurpose: To analyze immunohistochemically morules in endometrioid lesions to show that CD10 is a sensitive marker for morular metaplasia.
Experimental Design: Immunohistochemical analysis of 53 instances of morular metaplasia comprising 1 cyclic endometrium and 52 endometrioid lesions associated with focal glandular complexity corresponding to 9 polyps, 4 atypical polypoid adenomyomas, 24 complex endometrial hyperplasias (18 with and 6 without atypia), 12 grade 1 endometrioid adenocarcinomas in early clinical stages of both uterus and ovary, and three ovarian adenofibromas. Immunohistochemistry in paraffin sections was done for CD10, beta-catenin, estrogen and progesterone receptors, and cytokeratins 5-6, 7, 8,13,18,19, 20, and 34 beta-E12.
Results: Morules were negative for estrogen and progesterone receptors and had beta-catenin positive nuclei. Cytokeratins 8, 18, 19 were positive; cytokeratins 7 and 20 were negative; and cytokeratins 5-6, 13, and 34 beta-E12 were weakly positive. All cases revealed strongly positive membranous CD10 staining in morules, which was absent in glands. CD10 positivity allowed easy identification of morules at low power in various types of surgical specimens and in curettings. CD10 also highlighted early morular metaplasia in glandular epithelium. In cases associated with squamous, keratinizing metaplasia, CD10 discriminated between both types of metaplasia.
Conclusions: CD10 staining represents a useful marker of morules in endometrioid neoplasms of the female genital tract, permitting identification of lesions usually associated with an attenuated malignancy. Considering the immunohistochemical and genetic similarities of morules in tumors of different organs, it is likely that this marker may be also useful to diagnose morular metaplasia in similar neoplasms of extragenital locations
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Pseudomyxoma-type Invasion in Gastrointestinal Adenocarcinomas of Endometrium and Cervix: A Report of 2 Cases
Full text linkSummary: This paper presents a clinicopathologic and immunohistochemical report of 2
gastrointestinal-type tumors, one in the endometrium and the other in the cervix. Both
showed extensive invasion into the pelvic structures with acellular mucin, identical to
pseudomyxoma but in the absence of appendiceal or ovarian tumors. Case 1 was an 81-
yr-old female with a Stage III endometrial gastrointestinal-type adenocarcinoma who
had had an endometrial polyp with intestinal metaplasia 4 yr previously. Case 2 was a
68-yr-old female with Stage IIIB endocervical gastrointestinal-type adenocarcinoma.
Both were associated with a pseudomyxoma type of invasion, which in the endometrial
case was transmural through the myometrium, and in the cervical case involved
parametria, pelvic floor, and lymph nodes. Immunohistochemically, both tumors had a
gastrointestinal phenotype coexpressing cytokeratins 7 and 20, CDX2, villin, MUC2,
MUC5AC, and MUC6 and were negative for human papillomavirus, analyzed by realtime
polymerase chain reaction. The first case exemplifies intestinal endometrial
metaplasia as a precursor lesion of the rare gastrointestinal type of adenocarcinoma and
also proves its progression into carcinoma. The second case exemplifies the highly
aggressive nature of cervical invasion forming mucin lakes. Extensive pseudomyxoma in
the uterus and cervix was associated with high clinical stages with marked
lymphovascular invasion and lymph node metastase
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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