1,721,342 research outputs found
OPRM1 receptor as new biomarker to help the prediction of post mastectomy pain and recurrence in breast cance.
No full textBreast cancer is the most common type of cancer among women worldwide. Short--term post--surgical recovery is complicated by many factors, including imbalanced inflammatory and immune response, acute pain associated with functional impairment, and chronic post--mastectomy pain (CPMP), developed by about 25--60\% of patients. Opioids, most common drugs used for treatment of cancer pain, are immunosuppressive, and therefore, they might directly and/or indirectly influence long--term cancer recurrence. Moreover, they also produce endocrinopathy, which consists primarily of hypothalamic--pituitary--gonadal axis or hypothalamic--pituitary--adrenal axis dysfunction. The interindividual variability in both CPMP and opioid response is believed to be largely underlined by genetic variability in the gene locus for μ--opioid receptor (OPRM1) that modulates opioid pharmacodynamics. For this reason, OPRM1 genotype may play a key role both in short--term post--mastectomy outcome and in long--term follow up, becoming a new biomarker for breast cancer recurrence in patients suffering from chronic post--mastectomy pain managed by opioid therapy. Hence OPRM1 might be used in near future to customize the opioid therapy, avoiding not only opioid side effects but also the disease progression. In this review we evaluate the literature state of the art on this topic and possible steps towards obtaining the safest individualized post--mastectomy analgesic therapy. Therefore, a personalized pain treatment strategy might be useful to both manage pain and control cancer disease progression
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Intercity bus and rail services: Competition and welfare effects
No full textWe study the effects of the deregulation of intercity bus services in Europe on intermodal competition in long-distance land passenger transport and on social welfare. We consider a bus company with a flexible (Internet-based) business model and a rail operator with a rigid cost structure due to indivisibilities. We adjust the standard location model of horizontal differentiation to account for quality differences between modes, and for a bus capacity limit. We show that deregulation may turn the former rail monopoly on a route into a bus monopoly, particularly if bus quality is high enough and/or bus marginal cost is low enough. Since the bus is capacity constrained, then social welfare may be improved through a lump-sum transfer from bus to rail to restore competition and increase the number of travelers. Instead, we show that intermodal competition may reduce welfare (compared to rail monopoly) if the bus is inefficient and/or of low quality, so that bus services should be restricted by imposing quotas or even entry bans. Finally, we relax some assumptions and calibrate the model with data from the Genoa-Milan route in Italy. Numerical simulations confirm theoretical predictions and estimate annual welfare gains on the route under the compensation scheme
La valorizzazione del paesaggio nello sviluppo rurale
No full text"Improvement of Landscape in Rural Development": The paper deals with the problem of the value of landscape. In some cases the landscape value is increased by complementary goods, such as sporting facilities or restaurants, but in other cases the very landscape is a complementary good to other economical activities. Transition can happen in both directions, and the paper gives examples of both of them. Some original models are derived by merging Lotka-Volterra equations in the context of a system of evolutionary customer fidelization
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
