1,721,035 research outputs found
Prospects for new drugs to treat aberrant eating patterns: possible role of Oleoylethanolamide
Full text linkObesity is a complex pathology that occurs when energy intake exceeds energy expenditure and is characterized by the accumulation of dysfunctional adipose tissue which triggers metabolic stress response and induces a low-grade inflammatory chronic state at both central and peripheral levels. In the past years, research has focused on investigating the mechanisms involved in the control of feeding and energy balance to identify new pharmacological targets that could be potentially used in clinical practice for the treatment of pathological conditions characterized by multiorgan dysfunction, such as obesity. Among possible novel pharmacological targets, oleoylethanolamide (OEA) seems to be of particular interest based on its anti-obesity, anti-inflammatory, and antioxidant effects; OEA belongs to the lipid family of the N-acylethanolamines (NAEs) and is a potent endogenous ligand for peroxisome proliferator-activated receptor (PPAR)-α, a nuclear receptor involved in the transcriptional regulation of lipid metabolism, neuroplasticity and inflammation. In the present work was investigated in depth the effect of exogenous administration of OEA on molecular mechanisms involved in obesity-related alterations and on the endogenous oxytocinergic strictly implicated in both homeostatic and non-homeostatic control of eating behavior. Particularly, by using a diet-induced obesity (DIO) rat model we evaluated the impact of chronic peripheral administration of OEA on both brain and peripheral alterations. Moreover, we deeply investigated the possible alteration of the endogenous oxytocinergic system in different preclinical models of aberrant eating pattern (binge eating female rats, DIO rats and cafeteria rats models) and furthermore we assessed if the direct or indirect pharmacological manipulation of OEA system might impact such systems. In conclusion, the results reported in this work have the potential to unravel new targets for the development of pharmacological treatments for obesity and eating disorders, two major health problems worldwide
Supplemental material for Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice
No full textSupplemental Material for Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice by Davide De Biase, Francesco Esposito, Marco De Martino, Claudio Pirozzi, Antonio Luciano, Giuseppe Palma, Giuseppina Mattace Raso, Valentina Iovane, Stefania Marzocco, Alfredo Fusco and Orlando Paciello in Laboratory Animals</p
Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclooxigenase-2 in murine macrophage J774A.1
No full textLeptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclooxigenase-2 in murine macrophage J774A.1
No full textPharmacological and Nutritional control of dysbiosis related to CNS disorders: gut-brain axis
No full textNatural Antioxidants in the Pharmacological Treatment of Rheumatic Immune and Inflammatory Diseases
No full textEffects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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