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Il ruolo della dissezione linfonodale nel cancro gastrico: linfadenectomia D1 plus vs D2; risultati di sopravvivenza di un'analisi retrospettiva con il propensity score matching
No full textL'estensione di un'adeguata dissezione nodale ottimale per il cancro gastrico è ancora oggetto di discussione. Sebbene la linfadenectomia D2 nei paesi dell'Est risulti un trattamento standard, gli studi randomizzati occidentali hanno dimostrato un miglioramento per il controllo locale della malattia ma non hanno dimostrato un vantaggio in termini di sopravvivenza rispetto alla linfadenectomia D1. I risultati delle procedure D1 plus sono stati meno studiati, anche se risulta una procedura fattibile e sicura. Lo scopo di questo studio è di confrontare LNH (lymp hnode harvest) e risultati a lungo termine tra linfadenectomia D2 e D1 plus per i pazienti affetti da cancro gastrico.
Da 1005 pazienti sottoposti a gastrectomia per cancro gastrico, sono state selezionate 284 resezioni R0 consecutive (142 pazienti sottoposti a dissezione D1 plus e 142 pazienti sottoposti a dissezione D2) utilizzando il propensity score matching e le seguenti variabili: età, sesso, stadio e procedura chirurgica. Sono state eseguite analisi univariate e multivariate; le misure di outcome includevano LNH, OS, DFS e DSS.
Anche se gli stadi patologici erano coerenti con il matching, sono stati osservati una prevalenza di tumori T1-T2 e tumori del tipo intestinale nel gruppo D1 plus. Inoltre, il tasso di pazienti sottoposti a chemioterapia adiuvante era significativamente più alto nelle dissezioni D1 plus rispetto a quelle D2 (58,6% vs 42,0%, p 0,001). Come previsto, LNH era significativamente maggiore nel gruppo D2 rispetto al gruppo D1 plus (31,8 vs 28,0, p 0,006); tuttavia, le sopravvivenze riportate sono state simili. Lo stage era l'unica variabile correlata con la prognosi sull'analisi multivariata.
Le dissezioni D2 garantiscono un maggior LNH e le curve di sopravvivenza sono simili rispetto alle dissezioni D1 plus; tenendo in considerazione che i pazienti del gruppo D1 plus sono stati sottoposti in maggior numero a chemioterapia adiuvante.
(The extent of an optimal nodal dissection for gastric cancer is still a matter of debate. Although in Easter Countries D2 procedure isthegold standard treatment, Western randomized studies demonstrated an improvement for local disease control but failed in demonstrating a survival benefit comparing D1 lymphadenectomy.Opposite, the results of D1 plus procedures are less investigated,even if itis described as feasible and safe.The aim of this manuscript is to compare LNH and long-term outcomes of a two large matched series of D1 plus vs D2 resections for cancer.
From 1005 patients undergoneupfront gastrectomy for adenocarcinoma,284 consecutive R0resections (142 D1 plus and 142 D2) were selected using the propensity score method and the following covariates: age, sex, stage and surgical procedure. Univariates and multivariates analyses were performed; outcome measures included LNH,OS, DFS and DSS.
Although pathologic stages were consistent with matching, were observeda prevalence of T1-T2 tumors and intestinal type cancers in D1 plus dissections. Moreover, the rate of patients undergone adjuvant chemotherapy was significantly higher in D1 plus comparing D2 resections (58.6% vs 42.0%, p 0.001). As expected, LNHwas significantly greater in D2 vs D1 plus group (31.8 vs 28.0, p 0.006); however, survivals were reported similar. Stage was the only variable correlated with prognosis on multivariate analysis.
D2 dissectionsprovided a greater nodal harvest and similar survivals curves comparing with D1 plus, acknowledging the higher rate of adjuvant chemotherapy performed in thissub-group of patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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