1,721,092 research outputs found
Kinetic alterations of cytochrome-c oxidase in cystic fibrosis
No full textAbstractWe compared the kinetics of cytochrome-c oxidase (cytochrome-c: oxygen oxidoreductase, EC 1.9.3.1) in fibroblasts derived from normal and cystic fibrosis individuals. The Km of the enzyme for reduced cytochrome c was significantly increased in CF cells; the change, however, was observed only at temperatures above 25°C. The Vmax values were comparable in both types of individuals
Measurement of the lateral diffusion coefficients of ubiquinones in lipid vesicles by fluorescence quenching of 12-(9-anthroyl)stearate
No full textAbstractThe lateral diffusion coefficients of some ubiquinone homologues have been measured in phospholipid vesicles exploiting the fluorescence quenching of the probe 12-(9-anthroyl)stearate by the quinones. Diffusion coefficients higher than 10−6cm2 · s−1 have been found at 25°C, compatible with the localization of the ubiquinones in the low-viscosity midplane region of the bilayer
Respiratory supercomplex in rat liver mitochondria under phosphorylating and non-phosphorylating conditions: a kinetic approach by control flux analysis
No full textDetermination of partition and lateral diffusion coefficients of ubiquinones by fluorescence quenching of n-(9-anthroyloxy)stearic acids in phospholipid vesicles and mitochondrial membranes
No full textRespiratory Supercomplexes in Mitochondria.
Get PDFTable of contents
12.1. INTRODUCTION
12.1.1. The respiratory chain of mitochondria
12.1.2. Organization of the respiratory chain: historical outline
12.2. DISTRIBUTION AND COMPOSITION OF RESPIRATORY SUPERCOMPLEXES
12.2.1. Distribution in different organisms
12.2.2. Composition of respiratory supercomplexes
12.3. SUPERCOMPLEX ASSOCIATION PROVIDES A KINETIC ADVANTAGE
12.3.1. Structural evidence
12.3.1.1. Molecular structure of supercomplexes
12.3.1.2. Dynamic nature of supercomplexes: the plasticity model
12.3.1.3. The role of lipids: cardiolipin in supercomplexes
12.3.1.4. Standing uncertainties
12.3.2. Evidence for channelling in the Coenzyme Q region
12.3.2.1. Rate advantage in the Coenzyme Q region
12.3.2.2. Evidence for channelling by metabolic flux control analysis
12.3.2.3. Separate compartments of Coenzyme Q?
12.3.2.4. The function of the Coenzyme Q pool
12.3.2.4.1. Dissociation equilibrium of bound Coenzyme Q
12.3.2.4.2. Electron transfer between individual complexes not involved in supercomplex organization
12.3.2.5. Concluding evidence about channelling in the Coenzyme Q region
12.3.3. Electron transfer through cytochrome c
12.4. SUPERCOMPLEXES AND REACTIVE OXYGEN SPECIES
12.5. PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS
12.5.1. Supercomplexes and regulation of metabolic fluxes
12.5.2. Supercomplexes and ROS signalling
12.5.3. Supercomplexes in pathology and agin
Coenzyme Q-pool function in glycerol-3-phosphate oxidation in hamster brown adipose tissue mitochondria
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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