1,111 research outputs found
Foreword to The Organic Grower
No full textAudrey Windram is a living treasure of Australian organics. She has been ‘fighting the good fight’ to advance the cause of organics for the best part of half a century. When it comes to organics, Audrey leads by example. She has been living the organic life, variously as an organics pioneer, producer, evangelist, educator and author, all the while ‘practising what she preaches’ and preaching in the most gentle of ways. It is a delight to commend Audrey Windram’s latest book The Organic Grower on the fortieth anniversary of the publication of her first organics book. Organic Gardening originally appeared in 1975 as a Rigby Instant Book. It was a mass-market book distributed throughout Australia. The organics enterprise must continue to draw strength from the validity of its foundational premises and continue the fight which Lord Northbourne warned in 1940 may be a fight lasting “for many decades, perhaps for centuries”. In The Organic Grower Audrey Windram brings together four publications, Organic Gardening, the two volumes of Meet the Organic Farmer, together with Ways of Being Organic. Enjoy it
Audrey and Bill a romantic biography of Audrey Hepburn & William Holden
No full text"Here for the first time is the complete, captivating story of an on-set romance that turned into a lifelong love story between silver screen legends Audrey Hepburn and William Holden. In 1954, Hepburn and Holden were America's sweethearts. Both won Oscars that year and together they filmed Sabrina, a now-iconic film that continues to inspire the worlds of film and fashion. Audrey & Bill tells the stories of both stars, from before they met to their electrifying first encounter when they began making Sabrina. The love affair that sparked on-set was relatively short-lived, but was a turning point in the lives of both stars. Audrey & Bill follows both Hepburn and Holden as their lives crisscrossed through to the end, providing an inside look at the Hollywood of the 1950s, '60s, and beyond. Through in-depth research and interviews with former friends, co-stars, and studio workers, Audrey & Bill author Edward Z. Epstein sheds new light on the stars and the fascinating times in which they lived"-
Audrey Niffenegger @ The Cleveland Public Library
No full textAuthor and dedicated book artist Audrey Niffenegger autographs one of her books at an appearance she made as part of Octavofest 2011 at the Cleveland Public Library. Audrey Niffenegger is the acclaimed author of The Time Traveler\u27s Wife and Her Fearful Symmetry as well as the graphic novel, The Night Bookmobile. She is also a co-founder of the Columbia College Center for Book and Paper Arts in Chicagohttps://engagedscholarship.csuohio.edu/octavofest_gallery/1002/thumbnail.jp
Audrey Niffenegger @ The Cleveland Public Library
No full textAuthor and dedicated book artist Audrey Niffenegger autographs one of her books at an appearance she made as part of Octavofest 2011 at the Cleveland Public Library. Audrey Niffenegger is the acclaimed author of The Time Traveler\u27s Wife and Her Fearful Symmetry as well as the graphic novel, The Night Bookmobile. She is also a co-founder of the Columbia College Center for Book and Paper Arts in Chicagohttps://engagedscholarship.csuohio.edu/octavofest_gallery/1002/thumbnail.jp
Regulation of proNGF processing and its effects on p75NTR-mediated cell death following seizure
No full textNerve growth factor (NGF) has been known to play critical roles in neuronal survival and differentiation during development. Recent studies have
discovered that its immature form, proNGF, is a ligand for the p75 neurotrophin receptor (p75NTR). proNGF binding to p75NTR activates apoptotic signaling, and
this binding occurs with a five-fold higher affinity than that of mature NGF (Lee et al., 2001). This binding preference, along with the increased prevalence of
proNGF after injury (Harrington et al., 2004), creates a cellular environment susceptible to cell death; thus, the balance between levels of pro- and mature NGF may be a key factor in determining whether a neuron lives or dies (Lee et al., 2001; Volosin et al., 2006). Using both in vitro and in vivo methods, this thesis examined the mechanisms that regulate the extracellular processing of proNGF and the consequences of that processing on p75NTR-mediated cell death following injury. The results discussed here demonstrate that 1) proNGF binding leads to cell death via the p75NTR signaling pathway; 2) after injury, proNGF is upregulated and preferentially secreted in a functional manner capable of
activating the p75NTR-mediated apoptotic pathway; 3) the enzymes plasmin and MMP7 extracellularly cleave proNGF, 4) after injury, plasmin activation and
MMP7 activity are reduced, leading to increased proNGF-induced apoptosis, and 5) restoring plasmin or MMP7 activity following brain injury reduces proNGF
levels and consequently, p75NTR-mediated apoptosis. Overall, these data suggest that increased cell death following injury may be mediated in part by a
change in the balance between extracellular proNGF and the activity of its processing enzymes, leading to increased cell death via p75NTR.Ph.D.Includes bibliographical referencesIncludes vitaby Audrey P. L
Generation of Alzheimer´s disease (AD) patients' induced pluripotent stem cells (iPSC) derived neurons and production of a three-dimensional culture of neural networks for diagnostic and therapeutic research of AD
No full textLa maladie d’Alzheimer est une maladie très complexe, aujourd’hui encore mal comprise et cette démence est devenue un réel problème de santé publique. La protéine précurseur de l’amyloïde (APP) et la protéine Tau sont deux acteurs majeurs impliqués dans la maladie. De nombreuses recherches se sont investies dans la compréhension du métabolisme, de l’action et de l’implication de ces deux protéines dans les mécanismes pathologiques de la maladie et d’autres maladies neurodégénératives. Elles sont notamment l’objet de la plupart des approches thérapeutiques passées et actuelles, et étudiées pour le diagnostic biologique de la maladie. Dans ce projet de thèse, notre objectif fut d’explorer le métabolisme des protéines APP et Tau au cours de la différenciation neuronale à l’aide d’outils biochimiques et de systèmes innovants d’immunodétection multiplex très sensibles (MSD®) dans plusieurs modèles de culture cellulaire de la maladie. L’objectif était d’obtenir une vision globale des processus physiopathologiques au travers d’analyses d’échantillons générés au cours de la différenciation neuronale de cellules souches pluripotentes induites (iPSC) de patients Alzheimer comparées aux cellules souches embryonnaires humaines (hESC). Nous avons ainsi généré et caractérisé plusieurs lignées cellulaires d’IPSC d’une personne saine contrôle et de patients atteints des formes sporadiques et familiales de la maladie. Ce projet offre l’opportunité unique de combiner des approches innovantes pour tenter de comprendre comment les fragments et les peptides Ab sont générés, ainsi que les modifications de Tau en conditions normales et pathologiques.Amyloid precursor protein (APP) and Tau protein are two main molecular actors of the Alzheimer’s disease (AD), which is of prime importance in Human Health. Intensive research is ongoing to understand these proteins’ metabolism, action and implication in the pathological mechanism of these affections. They are the target of most therapeutic approaches and are used for biological diagnosis. In the present PhD project, our objective was to investigate neuronal APP and Tau protein processing and metabolism using biochemical tools and innovative multiplex immunodetection system (MSD®) in diverse cell culture models of AD. The goal was to get a comprehensive view oh physiopathological processes based on the analysis of samples generated in neuronal differentiated human embryonic stem cell and induced pluripotent stem cells derived from AD-patients. We generated several cell lines from an healthy control individual, and AD patients showing sporadic and familial forms of the disease. This project offer the unique opportunity to combine state-to-the-art approaches to understand how the APP fragments and peptides are generated as well as the modifications of the Tau protein in normal and pathological situation
Romance portrayed in Sophie Kinsella's finding Audrey Novel
No full textThis research aims to describe the relationship between Audrey and Linus relationship using John G. Cawelti formula theory. The study shows that author use pamela formula to describe the story plot
WHAT WE OWE TO CHILDREN: A RAWLSIAN PERSPECTIVE IN AN IRISH CONTEXT
No full textProvided by the author(s) and NUI Galway in accordance with publisher policies. Please cite the published version when available. Downloaded 2016-05-11T19:50:14Z Some rights reserved. For more information, please see the item record link above. Title What we owe to children: A rawlsian perspective in an irish context Author(s) Cahill, Audrey
Sharing a funder's perspective: using and supporting various approaches to communicate progress toward meeting ecological outcomes
No full textKen Fetcho, effectiveness monitoring coordinator & Audrey Hatch, conservation outcomes coordinatorTitle from PDF caption (viewed on December 27, 2022)This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposesMode of access: Internet from the Oregon Government Publications CollectionText in Englis
Audrey Macdonald’s Turkish Suite
No full textThe output engages with the field of Printmaking and cross-cultural dialogue in the visual arts. The work responded to a proposition by the curator, John Robinson, who had bought a second-hand book containing elements of a person’s life. The book contained the name Audrey MacDonald, an address in Edinburgh, a list of items to pack and a luggage label from the Hotel Rossiya in Moscow. Inspired by Turkish author Yashar Kemal’s novel, ‘They Burn Thistles’, my work engaged with the clues of cultural exchanges. The project aimed to engage artists in a thematic exhibition around imaging and imagining the life of a traveller. Audrey MacDonald was used as a premise for researching different cultural traditions responding to the location of Hobart based on travel and exposure. A variety of visual responses were explored with initial involving copying sections of Persian miniatures. These forms were abstracted and developed into a suite of lithographic collages. The works contrasted chance-based organic lithographic washes on Japanese rice paper against strong geometric forms redolent of architecture. Incorporated into the strategy was thinking through Hobart as ‘Edinburgh’ in the sense that the building blocks of the cities are directly related to the mountain rocks they are carved from. This continues my research into the integration of culture and place influenced by forms of printmaking that are accessible through trade and travel. This work innovates on cultural traditions combining languages and materials from Japan, Turkey, Europe and Australia.</p
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