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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Synthesis and SAR study of 2-substituted imidazo[2,1-b][1,3]benzothiazoles and related compounds endowed with affinity for dopamine D2 receptors as potential antipsychotics
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Synthesis and sar study of 2-substituted imidazo[2,1-b] [1,3]benzothiazoles and related compounds endowed with affinity for dopamine d2 receptors as potential antipsychotics
No full textSchizophrenia is a complex disorder affecting approximately 1% of the population.
Typical antipsychotic agents such as chlorpromazine and haloperidol block the D2 subtype of
dopamine receptors in a direct relation to their clinical potency. However, although blockade of
D2 receptors improves the positive symptoms of the disease, it also accounts for side effects which
strongly limit patient compliance, in particular extrapyramidal effects and hyperprolactinemia.
During the past few years, a second generation of antipsychotic agents has emerged
(e.g.,clozapine, risperidone, olanzapine, and ziprasidone); they are categorized as atypical in
contrast to conventional D2 blockers and exhibit a dual dopaminergic and serotonergic mechanism
of action: a relatively weak dopamine D2 receptor antagonism in vitro and in vivo, but potentially
important activities at other dopaminergic (D1, D4) receptors, at serotonergic (5-HT1A, 5HT2A,
5HT3, 5HT2C), adrenergic (a1, a2), histaminergic (H1), and muscarinic receptors. They are claimed
to be active against both positive and negative symptoms of schizophrenia, even though they do
exhibit a variety of other side effects as weight gain, postural hypotension, sedation, dry mouth.
For these reasons the search for more effective and less toxic agents still continues [1,2].
In this context we have developed a series of (1,2-diphenyl-imidazolyl)piperazine
derivatives (1) that are endowed with substantial affinities for both dopamine D2 receptors as well
as 5-HT1A and 5-HT2A serotonin receptors, compound 1a (R = o-OCH3) of which is representative [3].
We have extended our study on other series of compounds derived from 1 both modifying
the 1,2-diphenyl motif attached to the imidazole core, and the phenyl-piperazine moiety.
All novel compounds were submitted by Lundbeck to radioligand binding assay on
dopamine, serotonin, adrenergic, histaminergic receptor subtypes. The chemistry and the in vitro
screening will be discussed in the poster
Disegno metallurgico di una microstruttura alto resistenziale ad alta tenacità e deformabilità migliorata
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