46 research outputs found
The relation of the seen to the constructed image
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The influence of GSTM1-null, TS-del6bp, XRCC1-A751C gene polymorphisms on overall survival in colorectal cancer patients related to the TNM parameters: A Romanian single-center study
No full textEffects of dominant and non-dominant passive arm manoeuvres on the neurovascular coupling response
No full textPURPOSE: Models designed to study neurovascular coupling (NVC) describe a possible cerebral hemisphere dominance dependent on task completed and preference in handedness. We investigated whether passive arm manoeuvre performed with dominant (Dom-Arm) or non-dominant arm (ND-Arm) stimulated haemodynamic differences in either contralateral (Cont-H) or ipsilateral (Ipsil-H) cerebral hemisphere. METHODS: Healthy individuals lying in supine position, had measurements of beat-to-beat blood pressure (BP, mmHg), electrocardiogram (HR, bpm), end-tidal CO2 (etCO2, mmHg), and bilateral insonation of the middle cerebral arteries (MCA, cm s(-1)). Arm movement was performed for 60 s with passive flexion and extension of the elbow (1 Hz), before manoeuvre was repeated on other arm. Data were normalised and effect of treatment was analysed for differences between manoeuvres and within each time period. RESULTS: Seventeen (eight males) healthy volunteers, aged 56 ± 7 years, were studied. Dom-Arm and ND-Arm manoeuvres stimulated a comparable temporal response in peripheral and cerebral haemodynamic parameters between Cont-H and Ipsil-H. CONCLUSIONS: Both manoeuvres can be used to evoke similar bilateral MCA responses in assessing NVC. This finding should lead to more efficient protocols when using passive arm movement for NVC studies in healthy subjects
Pseudoaneurysm of Splenic Artery Ruptured in Pancreatic Pseudocyst and Complicated by Wirsungorrhagia: The Role of the Ultrasound Techniques and Contrast Substances
No full textImproving the performances of Diffusive Gradient in Thin-films (DGT) technique to measure the labile uranyl concentration in environmental waters by employing the chelating properties of siderochelates
No full textInternational audienceUranium (U) presents a unique challenge for ecological risk assessments around installations related to the nuclear fuel cycle because of both chemical and radiological toxicity. Their relative importance depends on the chemical speciation and isotopic composition of the radionuclide, the latter being strongly correlated to its natural or anthropogenic origin (enriched or depleted U) [1]. In this framework, the Diffusive Gradient in Thin-films (DGT) technique is an appealing tool for monitoring the water quality around uranium processing plants, nuclear facilities or mining areas. Indeed, the DGT sampling allows to preconcentrate in situ the labile U(VI) species, allowing to simultaneously characterize the labile UO22+ fraction in aqueous phase (i.e., this provides qualitative information on the "available stock of UO22+ for the aquatic organisms") and the isotopic composition at trace levels [2]. Among the eleven DGT methods developed for UO22+ [3], the ones containing Chelex-100® (an ion-exchange resin with iminodiacetic acid functional groups) or Metsorb® (a TiO2-based adsorbent) are the most employed due to their commercial availability. Nevertheless, their performances can be significantly degraded by high concentration levels of competing ions like Ca2+ in the deployment solution, which results in the underestimation of the overall concentration of labile U(VI) species in environmental waters [3, 4]. To improve the reliability of measurements, further analytical developments are therefore required. One important research direction includes the design of more selective UO22+ sorbent materials.In this study, we propose new DGT samplers for labile UO22+ species that incorporate novel complexing materials obtained by the covalent grafting of siderophore-like chelators on a hydrophilic organic resin. Siderophores are well-known to exhibit a high affinity for strong Lewis acids, such as iron(III) and actinide cations [5-7]. Rigorous laboratory validation of the new DGT devices was conducted, confirming the suitability of the samplers to quantitatively measure all UO22+ species in simple matrices in which UO22+-CO32– complexes dominate the speciation of U. In addition, cross-tests were performed with commercial Chelex-100® and Metsorb® based-DGT devices on several types of moderately basic waters (pH ≈ 8), either in the laboratory (i.e., soft and hard mineral waters and seawater) or during field tests. DGT probes were deployed in the alkaline surface water of the Œuf River, a tributary to the Seine River (France), in which Ca2+-UO22+-CO32– complexes are the dominant U species according to speciation modelling calculations. These experiments highlighted the superiority of the new DGT devices over those incorporating either Chelex-100® or Metsorb® sorbents. Finally, thermodynamic speciation calculations were performed as a first approach to better understand the functioning and potential limitations of our new and Chelex-100®-based DGT samplers in different deployment conditions.Acknowledgements:This work has been supported by IRSN, CNRS, and the French grant agency Agence Nationale de la Recherche (project PLUTON, grant n° ANR-17-CE08-0053). Osian FONQUERNIE and Tony FERNANDES are grateful to the Conseil Régional de Bourgogne Franche-Comté and the European Regional Development Fund (FEDER) for granting them a PhD fellowship. The authors thank Graver Technologies (www.gravertech.com) for the provision of the Metsorb® HMRP 50 products used in this study. All DGT experiments were performed at LUTECE (the SEDRE's experimental platform), and isotopic measurements at PATERSON (the IRSN's mass spectrometry platform). This work benefited from the knowledge acquired on the spatial and temporal distribution of U concentration in the Œuf-Essonne River through the research project UTOPIA conducted by Dr Mathilde ZEBRACKI (IRSN) and funded by the French program NEEDS.References:[1]T. Mathews, K. Beaugelin-Seiller, J. Garnier-Laplace, R. Gilbin, C. Adam, C. Della-Vedova, Environ. Sci. Technol. 2009, 43, 6684-6690[2]G. S. C. Turner, G. A. Mills, M. J. Bowes, J. L. Burnett, S. Amos, G. R. Fones, Environ. Sci.: Processes Impacts 2014, 16, 393-403.[3]V. Smolíková, P. Pelcová, A. Ridošková, M. Leermakers, Talanta 2022, 240, 123168.[4]G. S. C. Turner, G. A. Mills, P. R. Teasdale, J. L. Burnett, S. Amos, G. R. Fones, Anal. Chim. Acta 2012, 739, 37-46.[5]M. P. Neu, J. H. Matonic, C. E. Ruggiero, B. L. Scott, Angew. Chem. Int. Ed. 2000, 39, 1442-1444.[6]H. Boukhalfa, G. A. Icopini, S. D. Reilly, M. P. Neu, Appl. Environ. Microbiol. 2007, 73, 5897-5903.[7]L. Février, F. Coppin, S. Pierrisnard, M. Bourdillon, L. V. Nguyen, N. Zaiter, S. Brandès, V. Sladkov, J.-C. Chambron, M. Meyer, J. Environ. Radioact. 2021, 235-236, 106645
Reconstructing a Latina temple spire : Temple 45, Sanchi
No full textThe initial aim of this thesis is to reconstruct, through drawings, the original design of the spire from Temple 45, a ruined Latina temple from the Buddhist, World Heritage Site of Sanchi in Madhya Pradesh. The hundreds of un-analysed architectural fragments from the temple that survive on site are the primary data for this project: a veritable three-dimensional jigsaw puzzle of pieces waiting to be studied and reassembled. In order to turn the mass of architectural data collected at Sanchi into a virtual reconstruction of the spire from Temple 45, an authentic and detailed method of Latina spire design must be used. Finding such a method, one ratified by the Vastusasastras, by the shape of surviving Latina superstructures, and by the proportions of Temple 45 and its spire courses, forms the second, broader research question of the thesis. Although Latina temples are a seminal feature of North Indian temple architecture, scholars' explanations of how they were designed are inconsistent, incomplete and often unconvincing. In pursuit of this design method, therefore, the thesis explores the origination and development of the Latina temple form across Central India. It interrogates contemporary scholars' theories of Latina spire design and investigates the role that the Vastusasdstras may have played in the practises of early temple architects. Vastusasastric descriptions of Latina spire design are turned into drawings of spire elevations in order to assess their credibility, and in doing so a particular method of spire design is ratified and additional design details are suggested in order to provide a working explanation. Using this method, four sets of spire proportions given in a West Indian text called the DiparUava are validated. These are shown to create convincing Latina elevations with proportions that are borne out by surviving Central Indian Latina temples, by an engraving of a half Latina spire carved into the hallway of the Harihara 2 Temple in Osian, and by the proportions of Temple 45 its fragmented remains. Drawing from these findings, and returning to the initial aim of the thesis, the thesis proposes a detailed and convincing elevation of the spire from Temple 45.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Effects of dominant and non-dominant passive arm manoeuvres on the neurovascular coupling response.
No full textPURPOSE: Models designed to study neurovascular coupling (NVC) describe a possible cerebral hemisphere dominance dependent on task completed and preference in handedness. We investigated whether passive arm manoeuvre performed with dominant (Dom-Arm) or non-dominant arm (ND-Arm) stimulated haemodynamic differences in either contralateral (Cont-H) or ipsilateral (Ipsil-H) cerebral hemisphere. METHODS: Healthy individuals lying in supine position, had measurements of beat-to-beat blood pressure (BP, mmHg), electrocardiogram (HR, bpm), end-tidal CO2 (etCO2, mmHg), and bilateral insonation of the middle cerebral arteries (MCA, cm s(-1)). Arm movement was performed for 60 s with passive flexion and extension of the elbow (1 Hz), before manoeuvre was repeated on other arm. Data were normalised and effect of treatment was analysed for differences between manoeuvres and within each time period. RESULTS: Seventeen (eight males) healthy volunteers, aged 56 ± 7 years, were studied. Dom-Arm and ND-Arm manoeuvres stimulated a comparable temporal response in peripheral and cerebral haemodynamic parameters between Cont-H and Ipsil-H. CONCLUSIONS: Both manoeuvres can be used to evoke similar bilateral MCA responses in assessing NVC. This finding should lead to more efficient protocols when using passive arm movement for NVC studies in healthy subjects
Can we identify stroke sub-type without imaging? A multidimensional analysis
No full textHighlights: The study investigates stroke sub-type identification (AIS and ICH) using non-imaging hemodynamic parameters, providing an alternative to traditional imaging. The PCA-LR model showed high accuracy, with AUCs of ≥0.92 in two-fold and ≥0.79 in six-fold cross-validation for stroke sub-type differentiation. Baroreceptor sensitivity (BRS), cerebral hemodynamics, and peripheral parameters were key in distinguishing AIS from ICH. This non-imaging model provides promising guidance for future research on early stroke diagnosis and management, especially in pre-hospital settings lacking imaging. Further validation is required to distinguish stroke from stroke mimics, with larger studies required to refine its clinical utility
Gongs galore: phaleristic study of the relative risk of a healing art related New Year Honour
No full textObjectives To compare proportional representation of healthcare specialty workers, in receipt of New Year Honours (NYHs) and examine system bias.
Design Observational study of UK honours system including comparative analysis of proportional representation of the UK medical workforce.
Participants Recipients of NYHs from 2010 to 2019.
Main outcome measures Absolute risk of receiving an NYH, related to medical specialty, gender and geographical region. Relative risk (RR) of receiving an NYH for services to healthcare related to specialty.
Results 11 207 NYHs were bestowed, with 368 (3.3%) awarded to healthcare professionals: 212 (57.6%) women, 156 (42.4%) men. The RR of a healthcare professional receiving an NYH was 0.76 (95% CI 0.68 to 0.84, p<0.001) when compared with the remaining UK workforce. Doctors received most NYHs (n=181), with public health, clinical oncology and general medicine specialties most likely to be rewarded (RR 20.35 (95% CI 9.61 to 43.08, p<0.001), 8.43 (95% CI 2.70 to 26.30, p<0.001) and 8.22 (95% CI 6.22 to 10.86, p<0.001)), respectively; anaesthetists received fewest NYHs (RR 0.52 (95% CI 0.13 to 2.10), p=0.305). Men were more likely to receive NYHs than women (OR 0.44, 95% CI 0.36 to 0.54; p<0.001). Two hundred and fifty-four NYHs (69.0%) were bestowed on residents of England (60, 16.3% London), 49 (13.3%) Scotland (p=0.003), 39 (10.6%) Wales (p<0.001) and 26 (7.1%) Northern-Ireland (p<0.001).
Conclusions Relative risk of receiving an NYH varied over 150-fold by specialty, twofold by gender and threefold by geographical location. Public health physicians are perceived to be the pick of the parade
