104 research outputs found
Exposure to the agricultural fungicide tebuconazole promotes Aspergillus fumigatus cross-resistance to clinical azoles. [Comini S. is the co-first author; Banche G. is the corresponding author; Cuffini A.M. is the co-corresponding author]
No full textResistance to clinical triazoles in Aspergillus fumigatus is a growing concern for individuals at high risk of Aspergillus infection. Two triazole resistance selection routes are currently being investigated: one occurring in triazole-treated patients in healthcare settings, and the second taking place in the environment due to the widespread use of agricultural triazoles. This study aimed to assess the ability of agricultural azoles to promote cross-resistance to clinical azoles in A. fumigatus. Five A. fumigatus isolates susceptible to clinical azoles were exposed to the triazole 14α-demethylase inhibitor, tebuconazole (TBC), and then antifungal susceptibility tests for voriconazole, itraconazole, posaconazole and isavuconazole were performed. Under TBC selection pressure, all A. fumigatus isolates exhibited resistance to clinical triazoles. However, only two displayed a multiresistant phenotype to clinical azoles. TBC exposure was also associated with delayed conidia formation and progressive absence of conidiation. Noteworthy, no TBC-exposed clones harbored TR34/L98H mutation, as judged by real-time PCR assays. The observation that TBC exposure promotes cross-resistance to clinical triazoles warrants careful and thorough assessment of the human health risk associated with agricultural azoles. The absence of TR34/L98H mutation in cross-resistant A. fumigatus isolates suggests that other cyp51A mutations may be involved in clinical azole cross-resistance
Comparative analysis of biohumoral changes after surgery tot rea experimental obesità in the rat.
No full textINNOVATION POLICIES, START-UP COMPANIES AND SUPPORT ENTITIES. PRELIMINARY REGIONAL ANALYSIS OF THE INNOVATIVE COMPANIES’ DEVELOPMENT IN ITALY
No full textThe Italian economic context has witnessed, together with the other EU member states, a relevant growth of the attention towards innovative start-up companies. In the last 15 years there has been an increase in the number of centres for the development and support of innovative start-ups. Such centres (incubators, accelerators, info points, development agencies), created by governmental institutions, private entities and universities, have helped increase the number of start-up companies in Italy and to accelerate and modernise the approach towards the theme of innovation and technology transfer from the research to the market.
This paper analyses the data contained in the national companies’ register, in particular the section created by Law n. 221/2012, dedicated to innovative start-up companies, in order to find and evaluate the connections between the number and the nature of the innovative businesses established in the past few years, their place of birth, the presence of support structures in their regions of residence and the presence of other variables such as education level, IPR, R&D investments
Analisi comparativa delle modificazioni bio-umorali dopo interventi chirurgici eseguiti nel ratto per il trattamento dell' obesità sperimentale
No full textEnd-to-end jeiuno-ileal by-pass and truncal vagotomy without drainage are two of most common surgical technics performed in the treatment of morbid obesity.
The Authors evaluated hematologic indices in lean rats and their modifications in experimentally induced obese rats, before and after the described surgical procedures.
It was demonstrated that both jeiuno-ileal by-pass and truncal vagotomy were followed by a significant weight loss and a normalization of glucidic and lipidic metabolic disorders induced by experimental obesity.
For these reasons the Authors conclude that truncal vagotomy should be considered an alternative procedure to jeiuno-ileal by-pass in the treatment of experimental induced obesity in rats
The skin response in evaluation of the sympathetic chains after retroperitoneal lymphadenectomy. Preliminary report
No full textThe sympathetic skin response (SSR) permits recording of the sympathetic amyelinic fibres activity in relation to the function of sudoriparous glands. We recorded the SSR to check the efficacy of "nerve-sparing" technique in surgery of the sympathetic retroperitoneal postganglionic fibres following lymphadenectomy in nonseminomatous testis cancer. The results showed that SSR can be used to verify the integrity of the lumbar sympathetic chains after retroperitoneal lymphadenectomy.The sympathetic skin response (SSR) permits recording of the sympathetic amyelinic fibres activity in relation to the function of sudoriparous glands. We recorded the SSR to check the efficacy of "nerve-sparing" technique in surgery of the sympathetic retroperitoneal postganglionic fibres following lymphadenectomy in nonseminomatous testis cancer. The results showed that SSR can be used to verify the integrity of the lumbar sympathetic chains after retroperitoneal lymphadenectomy.The sympathetic skin response (SSR) permits recording of the sympathetic amyelinic fibres activity in relation to the function of sudoriparous glands. We recorded the SSR to check the efficacy of "nerve-sparing" technique in surgery of the sympathetic retroperitoneal postganglionic fibres following lymphadenectomy in nonseminomatous testis cancer. The results showed that SSR can be used to verify the integrity of the lumbar sympathetic chains after retroperitoneal lymphadenectomy. © 1994 Informa UK Ltd.The sympathetic skin response (SSR) permits recording of the sympathetic amyelinic fibres activity in relation to the function of sudoriparous glands. We recorded the SSR to check the efficacy of "nerve-sparing" technique in surgery of the sympathetic retroperitoneal postganglionic fibres following lymphadenectomy in nonseminomatous testis cancer. The results showed that SSR can be used to verify the integrity of the lumbar sympathetic chains after retroperitoneal lymphadenectomy. © 1994 Informa UK Ltd
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