1,191 research outputs found
Recommended from our members
Left ventricular mass and +276 G/G single nucleotide polymorphism of the adiponectin gene in uncomplicated obesity
No full textThe single nucleotide polymorphism at position 276 in the adiponectin gene (APM1/ACDC +276 G>T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We sought to evaluate whether +276 G>T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height(2.7)), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 +/- 10.2 years; BMI, 38.6 +/- 9.1 kg/m2). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese subjects with the APM1/ACDC +276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T genotype. G/G uncomplicated obese subjects showed significant higher LVM/body surface area and LVM/height(2.7) (within the normal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene
Effects of nilvadipine and amlodipine in patients with mild to moderate essential hypertension: A double blind, prospective, randomised clinical trial
No full textObjective: This double blind, prospective, randomised, parallel group clinical trial was aimed at investigating the effects of nilvadipine or amlodipine in mild to moderate hypertensive patients over a 3-month treatment period. Research design and methods: Eligible outpatients (supine DBP (greater-than or equal to) 90 mmHg and (less-than or equal to) 110 mmHg and supine SBP (less-than or equal to) 180 mmHg) entered a maximum 15-day placebo run-in period and were randomised to receive once daily nilvadipine 8 mg or amlodipine 5mg (to be doubled in the case of lack of response at day 30). Follow-up visits with measurement of supine and orthostatic blood pressure and heart rate were performed after 15, 30, 60 and 90 days of treatment. Standard laboratory tests and 12-lead ECG were performed at study entry and at the end of treatment; adverse events were collected at any time. Results: A total number of 168 patients, 83 in the nilvadipine and 85 in the amlodipine group, took part in the study: 15 and 14 in the two groups, respectively, were prematurely withdrawn. Supine DBP at endpoint similarly decreases in the two groups (-11.0 (plus or minus) 7.1 mmHg in the nilvadipine group and -12.7 (plus or minus) 8.2 mmHg in the amlodipine group), with no significant differences between groups at any time point. Measurements in the orthostatic position also did not show between-groups differences. Blood pressure was normalised in 61.8% of patients in the nilvadipine group and in 63.0% in the amlodipine group; responders to therapy were 64.5% and 69.1% in the two groups, respectively. Results of SBP also did not show differences between groups at any time point, except a more marked decrease in the amlodipine group compared to nilvadipine in the supine measurements at endpoint. A total number of 30 patients (36.6%) in the nilvadipine group and 23 (27.1%) in the amlodipine group reported adverse events (p = 0.24 between groups), which mainly consisted of vasodilatory effects (e.g. oedema, flushing and headache). A favourable lipid profile, i.e. a significant (p = 0.002 between groups) decrease of triglycerides levels and an increase of HDL-C, was observed in the nilvadipine group, compared with an increase of triglycerides in the amlodipine group. No effects on haematology, liver and renal function were observed in either group. Conclusions: Nilvadipine or amlodipine produced comparable effects on DBP and shared a similar adverse effect profile. A favourable effect on lipid profile was observed following nilvadipine treatment. (copyright) 2005 Librapharm Limited
Rivet clamping force of as-built hot-riveted connections in steel bridges
No full textHot-riveted connections have been widely used in the past for metallic bridges, of which a large part is still in service, making relevant the assessment of their fatigue life. Previous studies have shown that the fatigue behavior of hot-riveted connections depends on many factors; among these, the residual tensile force in the rivets that clamps the plates together, i.e. the clamping force, is one of the most prone to uncertainty and scatter. Investigations p in the past made use of specimens produced in controlled laboratory conditions, potentially leading to optimistic results. This paper presents an experimental investigation on the clamping force of as-built hot-driven rivets extracted from an old steel bridge. On average, the clamping stress was found to be ∼100 MPa and ∼60 MPa, but with large scatter, for two or three plates being clamped, respectively, and for grip length over diameter ratios close to unity. This significant dependency on the number of clamped plates, as well as the lower values observed as compared to earlier studies, are attributed to larger imperfections in rivets installed in-service, as compared to the controlled laboratory environment. In addition, a finite element model is presented that simulates the development of the clamping force following the installation of the rivet. The finite element model was validated on the basis of the experimental data and it appears able to predict the effect of the grip length on the clamping force. The larger the grip length over diameter ratio, the larger is the clamping force
Tolerability of long-term treatment with lercanidipine vs amlodipine and lacidipine in elderly hypertensives
No full textEl conflicto entre cristianos y musulmanes en las relaciones de sucesos: la “Liberación de Buda”
No full textConferència a càrrec de Francesca Leonetti, de la Universitat G. D’Annunzio di Chieti-Pescara, sobre el relat dels fets relacionats amb el conflicte entre cristians i musulmans i en concret, sobre els relats en vers de l' ocupació de Buda3201.mp4
3201.mp
Recommended from our members
Epicardial adipose tissue and insulin resistance in obese subjects
No full textCONTEXT: Epicardial adipose tissue has been recently recognized as a source of bioactive molecules as well as free fatty acids, adiponectin, and inflammatory cytokines. Epicardial fat reflects intraabdominal visceral fat, and the echocardiographic assessment of this tissue is an easy and reliable marker of visceral adiposity. OBJECTIVE: In this study we evaluated whether epicardial adipose tissue is related to insulin sensitivity and glucose metabolism in obese subjects. PATIENTS: Thirty obese subjects (20 women and 10 men; mean age, 40.8 +/- 11.5 yr; body mass index, 43 +/- 9.1 kg/m2) were included in this study. No subject was taking drugs or had a history or evidence of metabolic, cardiovascular, respiratory, or hepatic disease. MAIN OUTCOME MEASURES: Each subject underwent a transthoracic echocardiogram to evaluate epicardial adipose tissue thickness, a euglycemic hyperinsulinemic clamp to estimate insulin sensitivity, and an oral glucose tolerance test to evaluate glucose tolerance. RESULTS: The thickness of the epicardial adipose tissue on the right ventricle varied between 4 and 17.4 mm. Echocardiographic epicardial adipose tissue was significantly correlated with whole-body glucose uptake index from the clamp and with all indices of insulin resistance and glucose intolerance measured, except the 120-min plasma glucose level after an oral glucose tolerance test. CONCLUSIONS: Our study showed that the epicardial fat is significantly related to obesity-related insulin resistance. This finding could be of potential interest in clinical practice and research of obesity-related risk stratification
Sharp regularity for functionals with (q,p) growth
No full textWe prove regularity theorems for minimizers of integral functionals
of the Calculus of Variations
f(x; u;Du) dx;
with non-standard growth conditions of (p; q) type
|z |p< f(x; z) < L(| z| ^q +1); p < q:
In particular,we prove that a sufficient condition for minimizers to be
regular is q/p<(n+\alpha)/n ; where the function f(x; z) is Ho lder continuous
with respect to the x-variable. This condition is also
sharp. We include results in the setting of Orlicz spaces; moreover,we
treat certain relaxed functionals too. Finally,we address a problem
posed by Marcellini, showing a minimizer with an isolated singularity
Sums of Multivariate Polynomials in Finite Subgroups
No full textLet R be a commutative ring, f ∈ R[X1,⋯,Xk] a multivariate polynomial, and G a finite subgroup of the group of units of R satisfying a certain constraint, which always holds if R is a field. Then, we evaluate Σ f(x1,⋯,xk), where the summation is taken over all pairwise distinct x1,⋯,xk G. In particular, let ps be a power of an odd prime, n a positive integer coprime with p - 1, and a1,⋯,ak integers such that φ(ps) divides a1 + ⋯ + ak and p - 1 does not divide Σi∈Iai for all non-empty proper subsets I ⊆ {1,⋯,k}; then ∑x1a1⋯xkak ≡ φ(ps)/gcd(n,φ(ps))(-1)k-1(k - 1)!modps, where the summation is taken over all pairwise distinct nth residues x1,⋯,xk modulo ps coprime with p
Quasiconformal solutions to certain first order systems and the proof of a conjecture of G. W. Milton.
No full textAbstractWe study fine properties of the gradient of the solution to the conductivity equation div (σ(χ)▿u(χ)) = 0 in bounded domains. Our analysis is restricted to dimension two and it is concerned with merely measurable, elliptic coefficients. We establish sharp results on the higher order of integrability of the modulus of the gradient and of the inverse of the modulus of the gradient of the solution with the aid of recent advances in the theory of quasiconformal mappings due to Astala, Eremenko and Hamilton.We also consider the first order system associated to the second order elliptic equation, hence defining the map w = (u, ũ) and we isolate a class of Dirichlet boundary data on the function u which guarantees the quasiconformality of the mapping w. This leads in particular to a geometrical characterization of the electrostatic energy. We make use of results about the critical points of solutions of elliptic equations due to Alessandrini and Alessandrini and Magnanini
- …
