7,007 research outputs found
A problematic zygopleuroid gastropod Acanthostrophia revisited
No full textSEM examination of the type series of Acathostrophia acanthica CONTI & FISCHER, 1984 from Middle Jurassic of Italy has shown that this gastropod most likely belongs to the family Protorculidae as previously suggested by NÜTZEL (1998). It is also similar to some Jurassic species of Polygyrinidae, which might also be related to Protorculidae. The supposition of KAIM et al. (2008) that Acanthostrophia is an early member of Abyssochrysidae could not be confirmed
As relações entre a disciplina Laboratorio di Sintesi Finale do Politecnico di Milano e o ensino de projeto em moda no Brasil.
No full textA partir da experiência no Politecnico di Milano, acompanhando a disciplina Laboratorio di Sintesi Finale, de responsabilidade do professor Giovanni Conti, foi possível registrar as etapas que configuram um processo de projetação em moda e certa ordem para que elas ocorram. Durante esse período, foi possível observar com que frequência é utilizado o vocabulário e práticas do design industrial que, por vezes, é flexibilizado em função das necessidades específicas do design de moda. Além de frequentar as aulas de Conti, foi realizada uma entrevista de caráter exploratório com o docente, visando a coleta de dados primários mais precisos que, posteriormente foram tratados respeitando os métodos da História Oral para a construção de relatos, como aqueles de Alberti (2013), Poupart (2008) e Velho (1980). Dessa forma, a problematização do tema produzida como resultado dessa prática de pesquisa permitiu chegar a reflexões que expõem a importância da prática do design de moda e sua institucionalização para o avanço do campo
Material for knitwear: a new contemporary design scenario
No full textIn the actual globalized context in which the cross-fertilization among disciplines and different fields of project mixes together forms, systems and processes, Knitwear Design can make the difference in the production and in the consumption of the products.
Actually they are real insights on the various issues that characterize this area; today designing in very specific areas such as Italian knitwear, made of artists, designers, spinners, companies, perpetually poised between tradition and manual industrial product, makes research a really complicated challenge.
In contemporary scenarios knitwear design is a complex process, combining ancient techniques of traditional knowledge with experimentation and technological innovation. It’s a challenge that feeds the curiosity and the desire to seek more.En el contexto globalizado actual en el que la fertilización cruzada entre disciplinas y diferentes campos de proyecto se mezcla generando formas, sistemas y procesos, el diseño de Tejidos de Punto puede marcar la diferencia en la producción y en el consumo de los productos.
En realidad, son ideas reales sobre los diversos temas que caracterizan esta área. Actualmente el diseño en áreas muy específicas como diseño de tejido de punto italiano, realizado por artistas, diseñadores, hilanderos, empresas, continuamente entre la tradición y el producto manual industrial, hace de la investigación un desafío realmente complicado.
En los escenarios contemporáneos el diseño de tejido de punto es un proceso complejo, que combina antiguas técnicas tradicionales de conocimiento con la experimentación y la innovación tecnológica. Es un desafío que alimenta la curiosidad y el deseo de buscar más
The radical right in Europe, between slogans and voting behavior. IHS Political Science Series No. 123, July 2011
No full textThe paper analyzes the radical right‘s attitudes toward the EU focusing in particular on the level of congruence between the programmatic statements of the central office and the voting behavior of their MEPs. It shows that although radical right parties represent a source of opposition to the EU, within the EP they express their dissent making use of the rules of the game, voting with the opposition more than the other forces do, but voting almost as much with the majority. The party public office in the EP is inserted in the legislative process and even more collusive with the other parties of both sides of the political spectrum than the Eurosceptical rhetoric and statements of central office makes the public believe
Lettre de Armand de Bourbon, prince de Conti (gouverneur de Languedoc) et Claude Bazin de Bezons (intendant de Languedoc) à Jean-Baptiste Colbert (ministre d'Etat) datée du 22 décembre 1663, à Pezénas
No full textLettre de Armand de Bourbon, prince de Conti (gouverneur de Languedoc) et Claude Bazin de Bezons (intendant de Languedoc) à Jean-Baptiste Colbert (ministre d'Etat) datée du 22 décembre 1663, à Pezénas. In: Correspondance administrative sous le règne de Louis XIV, recueillie et mise en ordre par G. B. Depping. Tome I. Etats provinciaux – Affaires municipales et communales. Paris : Imprimerie nationale, 1850. pp. 128-129
Muttini-Conti G. — La popolazione del Piemonte nel secolo XIX
No full textC A. Muttini-Conti G. — La popolazione del Piemonte nel secolo XIX. In: Population, 21ᵉ année, n°1, 1966. pp. 159-160
Muttini-Conti G. — La popolazione del Piemonte nel secolo XIX
No full textC A. Muttini-Conti G. — La popolazione del Piemonte nel secolo XIX. In: Population, 21ᵉ année, n°1, 1966. pp. 159-160
Lettre de Armand de Bourbon, prince de Conti (gouverneur de Languedoc), François Adhémar de Monteil de Grignan (lieutenant général en Languedoc) et Claude Bazin de Bezons (intendant de Languedoc) à Jean-Baptiste Colbert (ministre d'Etat) datée du 01 février 1664, à Pezénas
No full textLettre de Armand de Bourbon, prince de Conti (gouverneur de Languedoc), François Adhémar de Monteil de Grignan (lieutenant général en Languedoc) et Claude Bazin de Bezons (intendant de Languedoc) à Jean-Baptiste Colbert (ministre d'Etat) datée du 01 février 1664, à Pezénas. In: Correspondance administrative sous le règne de Louis XIV, recueillie et mise en ordre par G. B. Depping. Tome I. Etats provinciaux – Affaires municipales et communales. Paris : Imprimerie nationale, 1850. pp. 141-142
Design, synthesis and biological characterization of PfGAPDH inhibitors
No full textMalaria has a tremendous health, social and economic impact on people living in tropical and subtropical regions of the world. WHO estimated 214 million cases and 438 000 deaths in 2015 and 3.2 billion people are globally at risk of infection1. Available treatments are becoming progressively less effective, mainly because parasites are constantly acquiring resistance toward the drug in use. Therefore, there is an urgent need of developing therapeutic agents acting on new targets.
Plasmodium parasites (P. falciparum is the most lethal), in their amastigote phase, produce energy only through glycolysis. In this pathway, GAPDH catalyses the first energy productive step and thus represent a valuable target for drug discovery. Known GAPDH inhibitors that bind to the active site are small nonselective molecules (iodoacetamide, 3-bromopyruvate), which irreversibly react with cysteine residues of the enzyme, including the catalytic one. We designed and synthesized the first series of inhibitors characterized by a 3-bromoisoxazoline warhead2, inspired by 3-bromoacivicin, a known inhibitor of reactive cysteine containing enzymes3. The compounds were assayed for the inhibitory activity on the P. falciparum isolated enzyme showing a biphasic irreversible inactivation. MS/MS studies of the digested protein demonstrated the mild reactivity of the exploited warhead, which only reacts with catalytic Cys (activated by a His residues). The human ortholog of GAPDH is only partially inhibited (up to 25%). We explained this through a negative cooperativity that prevents the alkylation of all the four monomers of hGAPDH, resulting in selectivity among the two isoforms of GAPDH4. Compounds were also assayed on cultures of the bloodstream form of P. falciparum and human cell lines in order to determine their in vitro antiparasitic activity and toxicity.
The goal of this project is to obtain compounds with improved potency and pharmacokinetic properties, suitable for in vivo studies on animal model of P. falciparum infections.
1. http://www.who.int/mediacentre/factsheets/fs094/en/
2. Bruno, S.; Pinto, A.; Paredi, G.; Tamborini, L.; De Micheli, C.; La Petra, V.; Marinelli, L.; Novellino, E.; Conti, P.; Mozzarelli, A. J. Med. Chem. 2014, 57(17), 7465-7471.
3. a) Conti, P.; Pinto, A.; Wong, P.E.; Major, L.L.; Tamborini, L.; Iannuzzi M.C.; De Micheli, C.; Barrett, M.P.; Smith, T.K. ChemMedChem 2011, 6(2), 329-333. b) Tamborini, L.; Pinto, A.; Smith, T.K.; Major, L.L.; Iannuzzi, M.C.; Cosconati, S.; Marinelli, L.; Novellino, E.; Lo Presti, L.; Wong, P.E.; Barrett, M.P.; De Micheli, C.; Conti, P. ChemMedChem 2012, 7(9), 1623-1634.
4. Bruno, S.; Margiotta, M.; Pinto, A.; Cullia, G.; Conti, P.; De Micheli, C.; Mozzarelli, A. Bioorg. Med. Chem. 2016, 24(12), 2654-2659
Populations of the Rio Negro steppe, challenges: for the social economy, community development and autonomy
No full textFil: Conti, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Conti, Santiago. Universidad Nacional de Río Negro; ArgentinaFil: Conti, Santiago. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio; ArgentinaFil: Nuñez, Paula G. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio; ArgentinaFil: Nuñez, Paula G. Universidad Nacional de Río Negro. Sede Andina; ArgentinaFil: Nuñez, Paula G. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaEl presente artículo recorre las actividades de un sector geográfico/poblacional históricamente invisibilizado. Aquel ubicado en la población de la estepa rionegrina, situada en la Patagonia argentina. Nuestro objetivo es dar cuenta de la interpelación a esa invisibilidad a partir de la valoración económica de actividades feminizadas, situadas en la producción artesanal. Tomamos como eje de nuestra reflexión a una experiencia comercial y productiva asociativa, el Mercado de la Estepa Quimey Piuqué. Mostraremos cómo, tras una experiencias asociativa se encuentra una fuerte disputa respecto de una mirada económica que históricamente ha ignorado las capacidades y potencialidades implícitas en esta experiencia, llevando a revisar el concepto mismo de la economía social
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