1,721,186 research outputs found
Re-set: fragmentos informáticos e identitarios y defragmentación del discurso en la poesía de Luis Bagué Quílez = Re-set: Informatic and Identitary Fragments, and Discourse Defragmentation in Luis Bagué Quílez's Poetry
No full textAmong the different paths that Spanish poetry has been traveling in recent decades, in Malos tiempos para la épica (Bagué and Santamaría, 2013) emerges the creative line that explores an objectual territory where subjectivity remains expectant behind the walls that contain reality. Such approache could reveal concerns for an unstable reality, which to a large extent derives from a fragmented materiality and with a difficult definition for the subjectivity. This situation is amplified by the lack of trust in the linguistic pact between signifier and signified. In this context, the purpose of this article is to analyze the poetry of Luis Bagué Quílez (Palafrugell, 1978) and more specifically in the collections Página en construcción (2011), Paseo de la identidad (2014) and Clima mediterráneo (2017); I will focus on the poems with semantic suggestions taken from the language of computer science to discover the activity of ‘de-construction’ of the poet, which alludes both to structuralist deconstruction and to the need to construct an acceptable order in a disrupted world in which words do not always mean what they should. The poetic subject is constantly being formed throughout the pages of Luis Bagué, but always bearing in mind the “Entorno Windows” to which we are subjected and the technique of the collage of times and spaces that shape us as travelers of a “World in progress”. A defensive sense of humor and an intense ironic figuration are the weapons at the poet’s disposal to confront this gradual pixelization of identity.Entre los diferentes caminos que la poesía española ha estado recorriendo en las últimas décadas, En Malos tiempos para la épica (Bagué; Santamaría 2013) se ha puesto de manifiesto la línea creativa que se adentra en un territorio objetual donde la subjetividad permanece expectante tras los muros que contienen lo real. Tales planteamientos podrían revelar las preocupaciones por una realidad inestable, que en gran medida deriva de una materialidad fragmentada y con una subjetividad de difícil definición. Todo esto se agudiza debido a la falta de confianza en el pacto lingüístico entre significante y significado, que caracteriza la que Steiner definió como época de la post-palabra. En este panorama, me propongo analizar la poética de Luis Bagué Quílez (Palafrugell, 1978), deteniéndome más concretamente en los poemarios Página en construcción (2011), Paseo de la identidad (2014) y Clima mediterráneo (2017) y analizando los poemas con sugerencias semánticas tomadas del lenguaje de la informática para descubrir la actividad de ‘de-construcción’ del poeta, que alude tanto a la deconstrucción estructuralista, como a la necesidad de construir un orden aceptable en un mundo trastornado en que las palabras no siempre significan lo que deberían. El sujeto poético está formándose constantemente a lo largo de las páginas de Luis Bagué, pero siempre teniendo presente el “Entorno Windows” al que estamos sometidos y la técnica del collage de tiempos y espacios que nos plasman como viajeros de un “World in progress”. Un defensivo sentido del humor y una intensa figuración irónica son las armas de las que dispone el poeta para enfrentarse a esta paulatina pixelización de la identidad
Neurodevelopmental genetic drivers of the human 22q11.2 region
Full text linkDespite substantial progress have been made to understand the wide spectrum of congenital anomalies and birth defects associated with 22q11.2 segmental aneuploidies, the highest comorbidity rate for neurodevelopmental disorders (NDDs) has been also recently showed in this cohort compared to any other genetic conditions. To further define, hence to experimentally confirm, the pivotal neurodevelopmental role of the 22q11.2 region we applied different approaches to identify those genes whose impairment may not only impinge on 22q11.2 rearrangements’ medical history as modifying factors, but that may also constitute per se NDDs’ driver-genes. Through a “genotype-first” approach we identified 8 genes (ARVCF, CLDN5, DGCR8, RANBP1, TRMT2A, MED15, AIFM3 and LZTR1) that, according to the enrichment criteria applied, can exert a downstream functional convergence upon those circuits involved in physiological neurodevelopment as well as in pathophysiological behaviors. By targeted resequencing two prioritized genes, ARVCF and LZTR1, we proved that: (i) their impairment can contribute to the genetic background toward variability of neurodevelopmental phenotypes seen in individuals carrying 22q11.2 CNVs; (ii) these genes may constitute per se NDD driver. Hence, in order to identify novel NDD genes potentially sensitive to dosage imbalance within the distal 22q11.2 chromosomal region, we developed a “phenotype-first” approach building the distal 22q11.2 CNVs “co-morbidity” map that allowed us: (i) to elucidate that the 22q11.2 distal deletion and duplication events respectively clinically define a syndromic versus a non-syndromic neurodevelopmental disorder; (ii) to identify two small NDD genomic regions of interest harbored within. Deeply investigating two rearranged 22q11.22q11.23 carriers’ families, whose segmental aneuploidies were retrieved fully incorporating one of our predicted pathogenic frames, we functionally showed that the RAB36 gene may play a role in NDD pathogenesis acting in a dosage-dependent manner. Overall, these research project’s results added new insights on the elucidation of 22q11.2-related neurobehavioral outcomes as well as of NDDs’ neuroscience physiopathology, widening the scope on those dynamics that constantly shape and re-shape the human brain
Aproximación y alejamiento de lo real maravilloso en la literatura hispánica de Guinea Ecuatorial. La obra literaria de Justo Bolekia Boleká
No full text«Mi poesía es una reflexión sobre el tiempo en el que vivo». Entrevista a Luis García Montero
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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