1,721,011 research outputs found
Piezoelectric nanomaterials for biomedical applications
No full textNanoscale structures and materials have been explored in many biological applications because of their novel and impressive physical and chemical properties. Such properties allow remarkable opportunities to study and interact with complex biological processes. This book analyses the state of the art of piezoelectric nanomaterials and introduces their applications in the biomedical field. Despite their impressive potentials, piezoelectric materials have not yet received significant attention for bio-applications. This book shows that the exploitation of piezoelectric nanoparticles in nanomedicine is possible and realistic, and their impressive physical properties can be useful for several applications, ranging from sensors and transducers for the detection of biomolecules to “sensible” substrates for tissue engineering or cell stimulation
Preparation, characterization and in vitro testing of poly (lactic-co-glycolic) acid/barium titanate nanoparticle composites for enhanced cellular proliferation
No full textThe recent advancements in tissue engineering
and, more in general, in cell-based applications, has led to
an ever increasing interest toward new materials for
sustained cell proliferation and differentiation. Here, the
preparation and the characterization of scaffolds based on
poly(lactic-co-glycolic) acid / barium titanate nanoparticle
composites are presented. In vitro testing on H9C2 cell line
demonstrates how the presence of the nanoparticles
positively affects both the proliferation and the differentiation
of this muscle-like cell line. Finally, the possibility to
obtain porous scaffolds and, therefore, an actual 3D culture
system, is introduced
Engineered materials for the development of bio-hybrid actuators
No full textIn this study we show the results obtained by co-culturing fibroblasts and skeletal muscle cells on micro-engineered hydrogels subjected to piezoelectric nanoparticle-mediated physical stimuli. Results suggest that these materials can be used for developing bio-hybrid devices, by synergistically combining tissue engineering and micro-mechatronics
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Osmolality control by inhalation or micro-infusions?
No full textA model of osmolarity is proposed in this paper. This model represents a typical example of embedded physiological feedback control in physiology. Extensive simulation tests with a compartmental approach (using the specific software SAAM II) have been performed, showing that the model agrees with the findings published in the literature of endocrine physiology and with medical practice. As a relevant example of application of the models, the diabetes insipidus pathology was considered. In the case of central insipidus diabetes, it is possible to predict effects of a therapy, giving out synthetic ADH (where ADH is the antidiuretic hormone, the vasopressine) for restoring homeostatic conditions
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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