287 research outputs found
Si ce n’était que moi, La sclérose latérale amyotrophique (ALS), Témoignage (If it was just me, Testimony)<em></em> : The translation from Swedish to French of <em>Om det bara var jag, </em>by Tina Jansson
No full text« Si ce n’était que moi, S’il ne s’agissait que de moi, j’y arriverais. Je m’en sors comme malade. Je peux vivre et penser à la mort. Je supporte les maux, qu’on me donne à manger et qu’on sèche mes fesses; mais, c’est aussi tous les autres, la famille, les enfants, les parents, les soeurs et frères, neveux et nièces, tantes, oncles, cousins et cousines, amis, voisins, connaissances… et les inconnus.» Mère de trois enfants, Tina Jansson est atteinte de sclérose latérale amyotrophique depuis 2006. Traduit du suédois en français par sa cousine Hedvig Brorsson-Jakobiak, son témoignage nous invite à partager l’intimité de cette maladie, également nommée la maladie de Charcot, à travers une collection de chroniques écrites au jour le jour. Au-delà de la peur, au-delà de la souffrance, l’auteur pose un regard lucide sur la vie et ses dérapages, avec distance, courage et humour.« If it was just me, if it was just about me. I would make it. I’ll work it out being ill. I can live and think of death. I can stand the pain, that I’m being fed and having my bottom wiped. But, it’s also the others, family, the children, parents, sisters and brothers, nephews and nieces, aunts, uncles, cousins, friends, neighbours, acquaintances... and the unknown.» Mother of three, Tina Jansson suffers from Amyotrophic lateral sclerosis since 2006. Translated from Swedish to French by her cousin Hedvig Brorsson-Jakobiak, her testimony invites us to share the intimacy of this disease, also called the Lou Gehrig’s disease, through a collection of daily chronicles. Beyond the fear, beyond suffering, the author poses a clear look on life and its skids, with distance courage and humour.</p
Diabetes during childhood and adolescence : studies of insulin treatment, patient-reported outcomes, and evaluation of an empowerment-based education
No full textThere is a lack of studies demonstrating positive effects on glycaemic control and HRQoL in children and adolescents starting CSII treatment. Guidelines recommend measuring perceived HRQoL routinely. It is important to have questionnaires, not overly comprehensive or timeconsuming, to measure HRQoL in children and adolescents as well as their parents. Structured and person-centred education has been emphasized as a key to successful selfmanagement. Guided Self-Determination-Young (GSD-Y) is a person-centred communication and reflection method. The overall aim of this thesis was to increase the knowledge regarding glycaemic control, type of treatment, HRQoL, and a theory-based education among youth with type 1 diabetes.Study I was a retrospective case-control study comparing children and adolescents starting CSII (n=216), with a control group treated with MDI (n=215). Children and adolescents who had started CSII showed improvement in glycaemic control, measured as HbA1c, during the first six months. For boys, this improvement could be identified throughout the first year. In Study II, 197 parents and their children with type 1 diabetes completed the proxy and child versions of the questionnaires Check your Health and DISABKIDS to test the psychometric properties of Check your Health by proxy. The test of the reliability and validity of this questionnaire showed acceptable psychometric properties. Study III, an RCT evaluating a GSD-Y education, included 71 adolescents starting CSII and their parents. The intervention group (n=37) attended seven group education sessions, lasting for about two hours each, using the GSD-Y method. The participants were followed for six months. The GSD-Y method showed a positive effect on glycaemic control, especially for participants with an HbA1c above 63 mmol/mol (n=48) at inclusion (p= 0.037); furthermore, readiness to change increased (p=0.037). A correlation was identified between HbA1c and goal achievement (rs=-0.475, p=0.001), and readiness to change (rs=-0.487, p=0.001). In Study IV, 13 adolescents were interviewed after the intervention with GSD-Y. From the qualitative analysis, two categories emerged: the importance of context, and growing in power through the group process. An overarching theme that emerged from the interviews was the importance of expert and referent power in growing awareness of the importance of self-management, as well as mitigating the loneliness of diabetes. Further, the findings showed that it is valuable for adolescents to meet other young people in the same situation, and to share their experiences from living with diabetes.In conclusion the four studies showed, treatment with CSII may initially result in improved HbA1c. Group education with the GSD-Y method, for adolescents and their parents, has the potential to further improve HbA1c, mitigate the loneliness of diabetes, and contribute to conscious reflection about self-management. The Check your Health questionnaire by proxy has shown acceptable psychometric characteristics, and may be useful in both studies and clinical settings.List of scientific papersI. Brorsson AL, Viklund G, Örtqvist E, Lindholm Olinder A. Does treatment with an insulin pump improve glycaemic control in children and adolescents with type 1 diabetes? A retrospective case-control study. Pediatr Diabetes. 2015;16:546-553. https://doi.org/10.1111/pedi.12209 II.Brorsson AL, Lindholm Olinder A, Wikblad K, Viklund G. Parent's perception of their children's health, quality of life and burden of diabetes: testing reliability and validity of 'Check your Health' by proxy. Scand J Caring Sci. 2016. https://doi.org/10.1111/scs.12362 III. Brorsson AL, Leksell J. Lindholm Olinder A. A person-centred education for adolescents with type 1 diabetes: guided Self-Determination-Young - A randomized controlled trial. [Submitted]IV. Brorsson AL, Lindholm Olinder A, Viklund G, Granström T, Leksell J. Adolescents’ perceptions of participation in group education using the Guided Self-Determination-Young method: a qualitative study. [Submitted]</p
Auto-clustering of Financial Reports Based on Formatting Style and Author’s Fingerprint
No full textpeer reviewedWe present a new clustering algorithm of financial reports that is based on the reports’ formatting and style. The algorithm uses layout and content information to automatically generate as many clusters as needed. This allows us to reduce the effort of labeling the reports in order to train text-based machine learning models for extracting person or company names, addresses, financial categories, etc. In addition, the algorithm also produces a set of sub-clusters inside each cluster, where each sub-cluster corresponds to a set of reports made by the same author (person or firm). The information about sub-clusters allows us to evaluate the change in the author over time. We have applied the algorithm to a dataset with over 38,000 financial reports (last Annual Account presented by a company) from the Luxembourg Business Registers (LBR) and found 2,165 clusters between 2 and 850 documents with a median of 4 and an average of 14. When adding 2,500 new documents to the existing cluster set (previous annual accounts presented by companies), we found that 67.3% of the financial reports were placed in the correct cluster and sub-cluster. From the remaining documents, 65% were placed in a different subcluster because the company changed the formatting style, which is expected and correct behavior. Finally, labeling 11% of the entire dataset, we can replicate these labels up to 72% of the dataset, keeping a high feature coverage.U-AGR-7012 - BRIDGES2020/IS/15403349/SCRiPT_Yoba Cont (01/04/2021 - 31/03/2024) - BRORSSON Mats Hakan9. Industry, innovation and infrastructur
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.
No full textBACKGROUND: The conversion of soluble peptides and proteins into polymeric amyloid structures is a hallmark of many age-related degenerative disorders, including Alzheimer's disease, type II diabetes and a variety of systemic amyloidoses. We report here that amyloid formation is linked to another major age-related phenomenon--prostate tissue remodelling in middle-aged and elderly men. METHODOLOGY/PRINCIPAL FINDINGS: By using multidisciplinary analysis of corpora amylacea inclusions in prostate glands of patients diagnosed with prostate cancer we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. In prostate protease rich environment the amyloids are stabilized by dystrophic calcification and lateral thickening. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro under native and acidic conditions and shows the characters of amyloids. This process is facilitated by calcium or zinc, both of which are abundant in ex vivo inclusions. These observations were supported by computational analysis of the S100A8/A9 calcium-dependent aggregation propensity profiles. We found DNA and proteins from Escherichia coli in CA bodies, suggesting that their formation is likely to be associated with bacterial infection. CA inclusions were also accompanied by the activation of macrophages and by an increase in the concentration of S100A8/A9 in the surrounding tissues, indicating inflammatory reactions. CONCLUSIONS/SIGNIFICANCE: These findings, taken together, suggest a link between bacterial infection, inflammation and amyloid deposition of pro-inflammatory proteins S100A8/A9 in the prostate gland, such that a self-perpetuating cycle can be triggered and may increase the risk of malignancy in the ageing prostate. The results provide strong support for the prediction that the generic ability of polypeptide chains to convert into amyloids could lead to their involvement in an increasing number of otherwise apparently unrelated diseases, particularly those associated with ageing.Original Publication:Kiran Yanamandra, Oleg Alexeyev, Vladimir Zamotin, Vaibhav Srivastava, Andrei Shchukarev, Ann-Christin Brorsson, Gian Gaetano Tartaglia, Thomas Vogl, Rakez Kayed, Gunnar Wingsle, Jan Olsson, Christopher M Dobson, Anders Bergh, Fredrik Elgh and Ludmilla A Morozova-Roche, Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate., 2009, PloS one, (4), 5, e5562.http://dx.doi.org/10.1371/journal.pone.000556
Yttrium barium copper oxide thin films on yttria-stabilized zirconia: growth and properties
No full textY Ba Cu oxide thin films were grown epitaxially on single cryst. yttria-stabilized zirconia substrates by laser deposition. [on SciFinder(R)
Growth and properties of a multilayer system based on Y1Ba 2Cu3Ox and amorphous Y-ZrO2
No full textThe growth of c-axis oriented Y1Ba2Cu 3Ox thin films on an amorphous buffer layer of Y-ZrO 2, deposited on sapphire substrates, was investigated. Both films were grown by a pulsed laser deposition technique. A strong correlation was observed between the properties of Y1Ba2Cu 3Ox and the thickness of the buffer layer. A Tc of 89 K was obtained for an optimal buffer layer thickness of 9 nm. A model that adequately describes the film growth process was developed. A multilayer system of Y1Ba2Cu3Ox and amorphous Y-ZrO2 was grown and a Tc of 87 K for the upper c-axis oriented layer was measured
The genetic and regulatory architecture of<i> ERBB3</i>-type 1 diabetes susceptibility locus
No full textThe study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D.</p
Study of in situ laser deposited YBCO thin films
No full textYBCO thin films were fabricated by laser deposition, in situ on MgO substrates, using both O2 and N2O as process gas. Films with Tc above 90 K and jc of 106 A/cm2 at 77 K were grown in oxygen at a substrate temperature of 765 °C. Using N2O, the optimum substrate temperature was 745 °C, giving a Tc of 87 K. At lower temperatures, the films made in N2O had higher Tc (79 K) than the films made in oxygen (66 K). SEM and STM investigations of the film surfaces showed the films to consist of a comparatively smooth background surface and a distribution of larger particles. Both the particle size and the distribution density depended on the substrate temperature.\ud
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LASER-DEPOSITED PRGAO3 FILMS ON SRTIO3 SUBSTRATES AND IN YBA2CU3O7/PRGAO3/YBA2CU3O7 TRILAYERS
No full textPrGaO3 films were successfully grown by laser deposition at temperatures between 730 and 785-degrees-C. The minimum full width at half maximum value of the (004) x-ray diffraction peak was 0.14-degrees, for films deposited on SrTiO3 substrates at 760-degrees-C. The optimum temperature for deposition of PrGaO3 in YBa2Cu3O7/PrGaO3/YBa2Cu3O7 trilayers was found to be 760-degrees-C. Three distinct layers were observed , and the PrGaO3 exhibited two orientations with respect to the c-axis oriented bottom layer; either the [001] or the [110] direction parallel to the YBa2Cu3O7 c axis. Two orthogonal in-plane orientations were observed for each of these cases. The highest resistivity (at 100 K) of the PrGaO3 layer was 10(5) OMEGA cm. Considerable interaction occurred between the PrGaO3 and the YBa2Cu3O7 bottom layer at 785-degrees-C, where the two bottom layers deteriorated.Physics, AppliedSCI(E)12ARTICLE4486-4886
Qualitative differences in the muscle activities in the forearm flexor and extensor muscles in healthy men and women in different ages
No full textBackground:Balance between flexor and extensor muscle activity is essential for optimal function. This has been demonstrated previously for the lower extremity, trunk and shoulder function, but information on the relationship in hand function is lacking.Objectives:The purpose of this study was to evaluate whether there are qualitative differences in finger extension force, grip force, force duration, force balance and the muscle activities in the forearm flexor and extensor muscles in healthy men and women in different ages.Methods:Healthy controls (men, n=65, women, n=40) were included. Primary outcome was muscle activity measured with S-EMG and finger flexion- and finger extension force in Newton (N). The maximal force from the first trial was used as reference value (maximal voluntary isometric contraction, MVIC). The S-EMG activity of the m. extensor digitorum communis (EDC) and the m. flexor carpi radialis (FCR) were measured on the dominant hand when performing seven clinically often used hand exercises. Hand function was also evaluated with the self-reported questioner Quick DASH and VAS pain and VAS stiffness.Results:The force balance between finger extension and flexion force was statistically significant for both men (r=0.51, p=0.000) and women (r=0.78, p=0.000). The finger extension force was not influenced by age, but flexion force was significantly correlated to age. The coefficient of determination showed that age and gender can explain 45-55% of differences in the force measurements. Muscle activity from hand exercises was significant related to gender for EDC and muscle activity in FCR showed significantly relation to age. Only 3 of the 7 hand exercise were adjustable for both men and women unrelatedly to age. Concerning the muscle activation in EDC and FCR in daily activities, the age and gender explain 31% respectively 19% of the differences.Conclusions:This study shows that there are differences between men and women's hand force capacity and that gender and age can explain 45-55% of the differences. Furthermore this study shows that the EDC muscle is related to gender and FCR is related to age. In a longer perspective this information is useful for designing optimal training program for adjusted for gender and age.References:Greig M, Wells R. A systematic exploration of distal arm muscle activity and perceived exertion while applying external forces and moments. Ergonomics. [Research Support, Non-U.S. Gov't]. 2008 Aug;51(8):1238-57.Nordenskiold U, Grimby G. Assessments of disability in women with rheumatoid arthritis in relation to grip force and pain. Disabil Rehabil. 1997 Jan;19(1):13-9.Kapandji I. The physiology of the joints - annotated diagrams of the mechanics of the human joints. Edingburgh London, Melborne and New York: Churchill Livingstone; 1982.Brorsson S, Nilsdotter A, Sollerman C, Baerveldt AJ, Hilliges M. A new force measurement device for evaluating finger extension function in the healthy and rheumatoid arthritic hand. Technol Health Care. 2008;16(4):283-92.Disclosure of Interest: None Declared</p
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