849 research outputs found
Hebbian and homeostatic synaptic plasticity of AMPA receptors in epileptogenesis
No full textAMPA receptors' synaptic plasticity is involved in epileptogenesis. In this issue, Eiro et al.(1) demonstrate that Hebbian plasticity is responsible for increased AMPAR in focal seizures, while homeostatic plasticity induces the reduction of AMPAR in generalized onset seizures
Marchi e contrassegni neopunici: spigolature e ipotesi sulla possibile organizzazione del cantiere della Curia di Leptis Magna
No full textAnalisi dei marchi neopunici incisi su alcuni blocchi dalla Curia di Leptis Magna, allo scopo di comprenderne le complesse dinamiche di approvvigionamento dei materiali e organizzazione del cantiere
Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy
No full textTemporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy, character-ized by recurrent spontaneous seizures originating in the temporal lobe(s), with mesial TLE (mTLE) as the worst form of TLE, often associated with hippocampal sclerosis. Abnormal epileptiform discharges are the result, among others, of altered cell-to-cell communication in both chemical and electrical transmissions. Current knowledge about the neurobiology of TLE in human patients emerges from pathological studies of biopsy specimens isolated from the epileptogenic zone or, in a few more recent investigations, from living subjects using positron emission tomography (PET). To overcome limitations related to the use of human tissue, animal models are of great help as they allow the selection of homogeneous samples still presenting a more various scenario of the epileptic syndrome, the presence of a comparable control group, and the availability of a greater amount of tissue for in vitro/ex vivo investigations. This review provides an overview of the structural and functional alterations of synaptic connections in the brain of TLE/mTLE patients and animal models
Hippocampal and neocortical dynamics at physiological or febrile temperature are not modified in the pre-epileptic period in a mouse model of Dravet syndrome.
No full textHippocampal and neocortical dynamics at physiological or febrile temperature are not modified in the pre-epileptic period in a mouse model of Dravet syndrome
La Curia diocesana : puertas abiertas para todos
No full textResumen: El artículo reflexiona acerca de la Curia, su organización y las personas que la conforman, considerando las características de las diócesis en la Argentina. El autor comparte su experiencia como Obispo diocesano, habiéndose desempeñado previamente como canciller y como vicario general, y presenta a la Curia como un espacio pastoral, proponiendo una curia de puertas abiertas.Abstract: This article reflects about the curia, its organization and the people that be part of it, considering the characteristics of the diocese in Argentina. The author share his experience as bishop, first being chancellor and vicar. He presents the curia as a pastoral space, proposing an open door curia
Preface to 'Advanced neurotechnologies: Translating innovation for health and well-being'
No full textBetween eternity and actualization: the co-evolution of the fields of communication in the Vatican
No full textMost research on structuration or the appropriation of ICT in organizations has put aside the problem of dyschronies. It has not taken into account the differences in nature, speed, and temporality of changes that co-exist within an organization. To address this limitation, the author of this paper suggests a model based on the theory of practice and neo-institutionalist perspectives, so as to make sense of the co-evolution of intra-organizational fields. This model, which proposes a balance between various institutional tensions, has been worked out inductively from a longitudinal case study on communication fields within the Roman Curia, the administrative headquarters of the Catholic Church located in the Vatican. These tensions are related to socio-technical, socio-theological, socio-organizational, and socio-economic areas. A set of propositions regarding the link between intra-organizational fields and tensions and the relationships between intra-organizational fields (parallel, convergent, and competing evolutions) is proposed.Keywords: Dyschronies; structuration; intra-organizational fields; communication; medias; ICT; Roman Curia
Wearable Electronics for Neurological Applications: A Review of Undergraduate Engineering Programmes
No full textNeuroscientists accept that we are indeed faced with an overwhelming challenge in understanding how the brain works. A better understanding of the brain will ultimately enable us to appreciate how well our students have grasped their learning materials. It will also enable us to diagnose and treat neurological disorders more effectively. Designing and developing the next generation of wearable devices is an important steppingstone towards this endeavor. Consequently, interdisciplinary efforts are required in co-creating educational materials that enable future neuro-engineers to develop these new devices. The aim of this article is to present a review of current undergraduate programmes that deal with this issue. Moreover, we provide recommendations for how new programmes in this field can be organized and delivered to ensure effective benefit for transnational students
Catalogo degli elementi architettonici
No full textCatalogo degli elementi architettonici sparsi nell'area della Curia di Leptis Magna
Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome
No full textThe absence of fragile X mental retardation protein results in the fragile X syndrome (FXS), a common form of mental retardation associated with attention deficit, autistic behavior, and epileptic seizures. The phenotype of FXS is reproduced in fragile X mental retardation 1 (fmr1) knockout (KO) mice that have region-specific altered expression of some gamma-aminobutyric acid (GABA(A)) receptor subunits. However, little is known about the characteristics of GABAergic inhibition in the subiculum of these animals. We employed patch-clamp recordings from subicular pyramidal cells in an in vitro slice preparation. In addition, semiquantitative polymerase chain reaction and western blot experiments were performed on subiculum obtained from wild-type (WT) and KO mice. We found that tonic GABA(A) currents were downregulated in fmr1 KO compared with WT neurons, whereas no significant differences were observed in phasic GABA(A) currents. Molecular biology analysis revealed that the tonic GABA(A) receptor subunits alpha5 and delta were underexpressed in the fmr1 KO mouse subiculum compared with WT. Because the subiculum plays a role in both cognitive functions and epileptic disorders, we propose that altered tonic inhibition in this structure contributes to the behavioral deficits and epileptic activity seen in FXS patients. This conclusion is in line with evidence implicating tonic GABA(A) inhibition in learning and memory
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