124 research outputs found
First person – Eriko Seo
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Eriko Seo is first author on ‘Roles of Keber's valve and foot chamber for foot manipulation in the mussel Nodularia douglasiae’, published in BiO. Eriko is a postdoctoral fellow in the lab of Prof. Shigeaki Kojima at The University of Tokyo, investigating the physiology of living bivalves
On the Inflence of "Fukui Prefectural Children's Science Hall" on User Consciousness
No full textIn this research, focusing on the cosmos and starry sky as regional resources, we aim to explore the influence of "Fukui Science Museum for Children" on the surrounding areas. In order to grasp the possibilities as regional resources, we designed and analyzed questionnaires for facility users. The main results are as follows: 1) The percentage of answer “use again" was very high (94%). Furthermore, the percentage of users recognizing that the facility has a positive influence on the surrounding area was also high. 2) After using the facility, knowledge of the cosmos and starry sky has deepened. Therefore, the users become more interested in the cosmos and starry sky. 3) About 9036626521351f respondents do not recognize the cosmos and starry sky as regional resources of Fukui. In Fukui, despite the existence of "facilities related to the cosmos" and "areas enjoying starry sky", they are not recognized as a regional resource at present.departmental bulletin pape
Vaccines for SARS-CoV-2: Lessons from Other Coronavirus Strains
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The composing processes of advanced Japanese language learners
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Ženski liki v literaturi Elfriede Jelinek
No full textV diplomski nalogi primerjam šest literarnih oseb (Sneguljčico, Trnjulčico, Jackie Kennedy, Sylvio Plath, Ingeborg Bachmann in Eriko Kohut) iz dramskega besedila Drame princes I-V in romana Učiteljica klavirja ,ter iščem njihove vzporednice. Pri vseh protagonistkah se pojavljajo motivi nefunkcionalnih odnosov, ki vplivajo na njihovo dojemanje spolnosti in nasilja. Avtorica preko nesamostojnih in podrejenih likov žensk demistificira enakopravnost med spoloma v sodobni demokratični družbi. Ženske so tako nesposobne osamosvojitve in izstopa iz zanje predhodno predpisanih vlog patriarhata.In my thesis, I compare six literary figures (Snow white, Sleeping beauty, Jackie Kennedy, Sylvia Plath, Ingeborg Bachmann and Erika Kohut) from the play Princess Dramas: Death and the Maiden and the novel The piano teacher by Elfriede Jelinek. All protagonists live in dysfuncitional relashionships that affect their perception of sexuality and violence. Through the indiscriminate and subordinate characters of women, the author demistifies gender equality in modern democratic society. Women are incapable of gaining independence and withdrawing from the previously prescribed roles of patriarchy
Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.
No full text3-Phosphoglycerate dehydrogenase (Phgdh) is the initial step enzyme in the phosphorylated pathway of L-serine biosynthesis. We have previously revealed in the brain that Phgdh is preferentially expressed in glial cells, but not in neurons, and that glia-borne L-serine exerts strong neurotrophic actions to neuronal survive, differentiation, and development. To investigate whether such an L-serine-meditated intercellular relationship is constructed in peripheral organs and tissues, we examined the kidney, which is one of the organs with the highest expression of Phgdh mRNA in the body. We found that Phgdh was distributed highly in the renal papilla and inner layer of the outer zone and moderately in the cortex, whereas it was almost negative in the outer layer of the outer zone. This heterogeneous distribution was due to selective expression in distinct tubular segments, i.e., the Bowman's capsule, proximal tubule, and thin limbs of the Henle's loop. Interestingly, neutral amino acid transporter ASCT1, which preferentially transports alanine, serine, cysteine, and threonine, was selectively expressed in Phgdh-negative tubular segments, i.e., the distal tubule and collecting duct. Therefore, either Phgdh or ASCT1 is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney too
Effect of mixed cropping with lupin (Lupinus albus L.) on growth and nitrogen uptake in pasture grasses grown under manure application
No full textThe use of organic fertilizer is essential to ensure sustainable agricultural production. Because organic fertilizer normally acts as a slow-release fertilizer, improving its nutrient-use efficiency is important, particularly in terms of nitrogen (N) nutrition. In the present study, we attempted to increase the N-use efficiency of cattle farmyard manure (CM) in the cultivation of pasture grasses by mixed cropping with white lupin (Lupinus albus), which has been reported to decompose organic N in its rhizosphere. Timothy (Phleum pratense) and orchard grass (Dactylis glomerata) were cultivated with or without either lupin or soybean (Glycine max) in pots under three different N treatments (CM, ammonium sulfate, or no N). In the CM treatment, growth was higher in grasses cultivated with lupin than in those cultivated alone or with soybean. Moreover, decomposition of soluble organic N and protease activity in the rhizosphere soil of grasses with CM treatment were enhanced by mixed cropping with lupin. Analyses of microbial activity and bacterial community structure using Biolog EcoPlates suggested that the enhanced decomposition of soluble organic N was facilitated by lupin roots rather than by rhizosphere microorganisms
A methodological and preliminary study on the acoustic effect of a trumpet player’s vocal tract
No full textMitochondrial-targeted DNA delivery using a DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes
No full textMitochondrial gene therapy has the potential to cure a variety of diseases that are associated with mitochondrial DNA mutations and/or defects. To achieve this, it will be necessary to deliver therapeutic agents into the mitochondria in diseased cells. A number of mitochondrial drug delivery systems have been reported to date. However, reports of mitochondrial-targeted DNA delivery are limited. To achieve this, the therapeutic agent must be taken up by the cell (1), after which, the multi-processes associated with intracellular trafficking must be sophisticatedly regulated so as to release the agent from the endosome and deliver it to the cytosol (2) and to pass through the mitochondrial membrane (3). We report herein on the mitochondrial delivery of oligo DNA as a model therapeutic using a Dual Function (DF)-MITO-Porter, an innovative nano carrier designed for mitochondrial delivery. The critical structural elements of the DF-MITO-Porter include mitochondria-fusogenic inner envelopes and endosome-fusogenic outer envelopes, modified with octaarginine which greatly assists in cellular uptake. Inside the cell, the carrier passes through the endosomal and mitochondrial membranes via step-wise membrane fusion. When the oligo DNA was packaged in the DF-MITO-Porter, cellular uptake efficiency was strongly enhanced. Intracellular observation using confocal laser scanning microscopy showed that the DF-MITO-Porter was effectively released from endosomes. Moreover, the findings confirmed that the mitochondrial targeting activity of the DF-MITO-Porter was significantly higher than that of a carrier without outer endosome-fusogenic envelopes. These results support the conclusion that mitochondrial-targeted DNA delivery using a DF-MITO-Porter can be achieved when intracellular trafficking is optimally regulated
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