711 research outputs found
Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia
No full textB-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course. Recent studies have shown that expression of lipoprotein lipase (LPL) and ADAM29 may serve as novel prognostic markers in B-CLL. To investigate the prognostic value of these genes, we quantified their expression in peripheral blood mononuclear cells using quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR) in a cohort of 133 B-CLL patients and correlated the results with clinical outcome, and other known prognostic factors. LPL, ADAM29, LPL and ADAM29 ratios, as well as CD38 and ZAP-70 protein expression determined by multiparameter flow cytometry, were predictive of treatment-free survival. Multivariate Cox regression analysis identified LPL, ADAM29 and CD38 as independent prognostic markers. Evaluation of several disease characteristics in association with the LPL expression status of the patients' B-CLL cells showed highly significant differences for CD38 and ZAP-70 expression, suggesting a correlation of LPL expression with these established adverse prognostic factors. Sequential RQ-PCR analyses in a subset of 22 patients revealed that LPL mRNA expression was relatively stable in the majority of patients, whereas ADAM29 expression levels varied substantially over time. Furthermore, in a subgroup analysis, LPL provided prognostic information in both early stage (Binet A) and patients with more advanced disease (Binet B and C). Conversely, high ADAM29 expression was predictive of a long treatment-free interval in Binet stage A but did not retain its prognostic significance in Binet B and C patients. The LPL/ADAM29 expression ratio was not found to be an independent prognostic factor and did not offer any advantages over the use of LPL alone. Collectively, our data confirm a role for LPL as a novel prognostic indicator in B-CLL
Vector-borne pathogens in clinically healthy military dogs and vector surveillance in eastern Austria
No full textDissertation - Veterinärmedizinische Universität Wien - 2023Die Ausbreitung von durch Vektoren übertragenen Krankheitserregern ist ein zunehmendes Problem für die Gesundheit von Mensch und Tier. Extensiv gehaltene Hunde, sowie ihre Halter können einem höheren Risiko einer Infektion ausgesetzt sein. In der vorliegenden Studie wurden 94 klinisch gesunde Hunde, die in extensiver Haltung in einem Militärhundezentrum leben, auf vektorübertragene Krankheitserreger untersucht. Es wurden in Summe 144 Blutproben entnommen und auf vektorübertragene Krankheitserreger untersucht. Es wurden Infektionen mit Dirofilaria repens, Babesia canis und Borrelia burgdorferi s.l.-Komplex festgestellt. Dies unterstreicht die Notwendigkeit, die Überwachung von Wirtspopulationen in die Überwachung von vektorübertragenen Krankheiten einzubeziehen. Zusätzlich wurden Zecken und Mücken im Militärhundezentrum gesammelt und untersucht. Es wurden 71 Mückenindividuen von zehn Arten gefunden. Davon sind Ae. vexans und C. pipiens s. l. auch als kompetente Vektoren für D. repens bekannt. Während D. repens in der Militärhundepopulation nachgewiesen wurde, fanden sich in den Stechmücken keine Hinweise auf Dirofilarien. Insgesamt wurden außerdem 1324 Zecken untersucht. Die häufigste Art war I. ricinus (92,9 %), gefolgt von Haemaphysalis inermis (3,6 %), D. reticulatus (3,1 %) und Haemaphysalis concinna (0,4 %). Der Nachweis von H. inermis als zweitgrößte Teilprobe war unerwartet, da diese Art in Österreich seit langem nicht mehr nachgewiesen wurde. Von den in den Hundeblutproben nachgewiesenen Krankheitserregern wurde jedoch nur B. burgdorferi s.l. bei der Vektorüberwachung gefunden. In den gesammelten Zecken wurden mehrere andere potenziell pathogene Mikroorganismen nachgewiesen. Drei davon wurden in Österreich bisher nur sporadisch nachgewiesen (Borrelia mijamotoi, Borrelia lustinaniae und Babesia microti). Zusätzlich konnten in den untersuchten Zecken die folgenden Mikroorganismen nachgewiesen werden: Borrelia afzelii, , Borrelia garinii, Borrelia burgdorferi s. s.,, Borrelia valesiana, Rickettsia helvetica, Rickettsia monacensis, Rickettsia raoultii, Rickettsia sp., Bartonella spp., und Arsenophonus sp. Aufgrund dieser Ergebnisse sowie der Arbeitsbedingungen von Militärhunden und ihren Hundeführern, sind eine verstärkte Sensibilisierung und die Evaluierung von Schutzmaßnahmen im Hinblick auf vektorübertragene Krankheiten erforderlich.Dissertation - University of Veterinary Medicine Vienna - 2023The spread of vector-borne pathogens is an increasing concern for both human and animal health. Extensively housed dogs, as well as their handlers, may be at higher risk for infection with vector-borne diseases. In the present study, 94 clinically healthy dogs living in extensive housing in a military dog center were clinically examined for vector-borne pathogens. In addition, a total of 144 blood samples were collected from these dogs for laboratory screening for vector-borne pathogens, whereby infections with Dirofilaria repens, Babesia canis, and Borrelia burgdorferi s.l. complex were detected. These results emphasize the need to incorporate host population surveillance into vector-borne disease monitoring. In addition, ticks and mosquitoes were collected and examined for the present study at the Military Dog Center. Seventy-one mosquito individuals of ten species were found. Of these, Aedes vexans and Culex pipiens s. l. are known competent vectors for D. repens. While D. repens was detected in the military dog population, no evidence of dirofilariae was found in the mosquitoes. Furthermore, a total of 1324 ticks were found and examined. The most common species was Ixodes ricinus (92.9%), followed by Haemaphysalis inermis (3.6%), Dermacentor reticulatus (3.1%) and Haemaphysalis concinna (0.4 %). The detection of H. inermis as the second largest subsample appeared unexpected, as this species had not been detected in Austria in a long time. However, of the pathogens detected in the dog blood samples, only B. burgdorferi s.l. was found in the vector species. Several other potentially pathogenic microorganisms were detected in the collected ticks. Three of these have been detected only sporadically in Austria before (Borrelia mijamotoi, Borrelia lustinaniae and Babesia microti). In addition, the following microorganisms were detected in the examined ticks: Borrelia afzelii, Borrelia garinii, Borrelia burgdorferi s.s., Borrelia valesiana, Rickettsia helvetica, Rickettsia monacensis, Rickettsia raoultii, Rickettsia sp., Bartonella spp, and Arsenophonus sp.. Based on the results acquired in the current study, as well as the working conditions of military dogs and their handlers, increased awareness and evaluation of protective measures especially for extensive canine husbandry and work are needed regarding vector-borne diseases
Institutionalizing ASEAN: celebrating Europe through network governance
No full textThis article provides a new piece for two of the puzzles of institutionalized cooperation in Association of Southeast Asian Nations (ASEAN). First, with regard to the organization's four decades of existence, there has always been a marked gap between ASEAN's rhetorical goals of cooperation and its actual achievements. What explains these systematic failures of implementation? Second, from the outset, ASEAN was criticized for its light institutionalization, which failed to deliver the substantial cooperation goals. Despite selected institutional reforms, ASEAN's autonomy has not increased remarkably and it has not made any major institutional innovations. Why does ASEAN design institutions it does not use? Why does this transformation gap occur? The author suggests a sociological institutional explanation and argues that major impulses for cooperation have come from outside Southeast Asia, most importantly from Europe. By mimicking the European integration process, ASEAN member states have effectively created an isomorphic organization. The Association's institutional development reflects a concern for international legitimacy and less an objective functional demand arising from the specific interactions of member states. This copying process has led to network governance within the organization
The Vietnamese Theatrical Tradition in the Plot of Monsun, by Anja Hillin
No full textFrom the dramatic text Monsun by the German author Anja Hilling, this article analyzes the construction of a plot using elements of the Asian theater, in this specific case the Vietnamese tradition, identifying its presence inthe structure beyond the constant references to the context of that country, starting with the title of the play itself and the trip of one of the characters to Vietnam.A partir do texto dramático Monsun, da autora alemã Anja Hilling, este artigo analisa a construção de uma trama que se utiliza de elementos do teatro asiático, neste caso específico a tradição vietnamita, identi cando a sua presença na estrutura, além das men- ções constantes ao contexto daquele país, começando pelo próprio título da peça e pela viagem de uma das personagens ao Vietnam. 
Discussing Anja Štefan`s fairytales in the first year of primary school
No full textFairytales are an indispensable part in children's lives. They stimulate the development of imagination, fantasy; they help to enrich children’s vocabulary and with expressing feelings. There are different types of fairytales and it is very important that children get to know the variety of them. I firstly presented a youth author Anja Štefan and her literary works in my diploma paper. Later on I continued with the presentation of youth literature and I defined the theory of a fairytale, wrote about the origin, its meaning and classification of fairytales which I have also described in greater detail. I stated and described authorial prose work of Anja Štefan: picture book Lešniki, lešniki and classic fairytales Kotiček na koncu sveta, Melje, melje mlinček and Štiri črne mravljice, which can be defined as animal fairytales. I was interested in the receptive development of children in the period of intuitive intelligence, which I thoroughly described. In the empirical part of my diploma I wrote lesson plans for discussing and teaching three Anja Štefan’s animal fairytales in the first grade of primary school. 25 children took part in the research. I found out that pupils distinguish between real and unreal life (imaginative life), they are capable of identifying themselves with a literary person and they perceive animals as literary persons and they identify themselves with them
Correction to: Predicting the effectiveness of protected areas of Natura 2000 under climate change
No full textIn the original publication of this article (Nila & Hossain, 2019), co-authors ‘Carl Beierkuhnlein, Anja Jaeschke and Samuel Hoffmann’ need to be added to the author list
The establishment history panel 1975-2006 : handbook Version 2.0.1
No full text"The Establishment History Panel (BHP) for 1975 to 2006 includes all of the establishments throughout Germany which have at least one employee liable to social security as of the 30th of June of a given year or which have also had at least one marginal part-time employee as of 1999. For establishments in West Germany the observation period is the period 1975 to 2006 and for establishments in East Germany 1991 to 2006. The data source for the BHP is the Employee and Benefit Recipient History (BLH) of the IAB. The data on individuals contained in the BLH are aggregated to establishment level using the establishment numbers. The BHP covers between 1.3 and 2.7 million establishments per year. The individual annual waves can be linked to a panel dataset via the identifier 'artificial establishment number', which can be found in the dataset. This data report describes the variables of the weakly anonymous version of the 1975-2006 BHP basic dataset, which is available to researchers for on-site use at the Research Data Centre (FDZ) or for remote data access also. These BHP data are predominantly original data, with the sole exception that the original establishment numbers, which are direct identifiers for the different establishments, were replaced by artificial establishment numbers. The sensitive characteristics contained in the dataset, i.e. German Classification of Economic Activities 93 as 5- digit codes, German Classification of Economic Activities 03 as 5-digit codes, and Place of Work (District), are made available in the original on request and in well-founded cases only; all other users are given these variables in their aggregate forms only (as 3-digit codes or according to German States). This report will begin with a brief description of the sources used for the BHP, as well as the generation and processing of the BHP, followed by individual detailed explanations on the variables of the BHP 1975-2006. This data report contains no frequency tables for the individual variables. These are given in a separate text file that can be found on the FDZ homepage. To begin with, a brief overview of the changes to the BHP 1975-2006 in relation to the previous version from 1975-2005 is provided. This will help users of this version come to terms with the new version." (Author's abstract, IAB-Doku) ((en)) Additional Information Here you find frequency tables for the individual variables. Here you can find the German version.IAB-Betriebs-Historik-Panel, IAB-Beschäftigtenhistorik, IAB-Leistungsempfängerhistorik, Datenaufbereitung, Forschungsdatenzentrum, Arbeitsmarktforschung, Datenorganisation, Betrieb, Wirtschaftszweige, regionale Verteilung, Unternehmensgründung, Betriebsstilllegung, Beschäftigtenstruktur, sozialversicherungspflichtige Arbeitnehmer, erwerbstätige Frauen, Inländer, Ungelernte, Qualifikationsniveau, Bildungsabschluss, Schulbildung, Berufsausbildung, Studienabschluss, Fachhochschule, Hochschule, Vollzeitarbeit, Stellung im Beruf, Auszubildende, nicht formal Qualifizierte, Facharbeiter, Polier, Meister, Angestellte, Teilzeitarbeitnehmer, Heimarbeitnehmer, geringfügige Beschäftigung, Altersstruktur, Lohnstruktur, Lohnhöhe, Vollzeitarbeit, Nationalität, Jugoslawe, Osteuropäer, Pole, Spanier, Portugiese, Türke, Beschäftigtenstatistik
The establishment history panel 1975-2005 : handbook version 2.0.0
No full text"The Establishment History Panel (BHP) for 1975 to 2005 includes all of the establishments throughout Germany which have at least one employee liable to social security as of the 30th of June of a given year or which have also had at least one marginal part-time employee as of 1999. For establishments in West Germany the observation period is the period 1975 to 2005 and for establishments in East Germany 1991 to 2005. The data source for the BHP is the Employee and Benefit Recipient History (BLH) of the IAB. The data on individuals contained in the BLH are aggregated to establishment level using the establishment numbers. The BHP covers between 1.3 and 2.5 million establishments per year. This data report describes the variables of the weakly anonymous version of the 1975-2005 BHP basic dataset, which is available to researchers for on-site use at the Research Data Centre (FDZ) only. These BHP data are predominantly original data, with the sole exception that the original establishment numbers, which are direct identifiers for the different establishments, were replaced by artificial establishment numbers. The sensitive characteristics contained in the dataset, i.e. German Classification of Economic Activities 93 as 5-digit codes, German Classification of Economic Activities 03 as 5-digit codes, and Place of Work (District), are made available in the original on request and in well-founded cases only; all other users are given these variables in their aggregate forms only (as 3-digit codes or according to German States). This report will begin with a brief description of the sources used for the BHP, as well as the generation and processing of the BHP, followed by individual detailed explanations on the variables of the BHP 1975-2005. This data report contains no frequency tables for the individual variables. These are given in a separate text file that can be found on the FDZ homepage. To begin with, a brief overview of the changes to the BHP 1975-2005 in relation to the previous version from 1993-2003 is provided. This will help users of this version come to terms with the new version." (Author's abstract, IAB-Doku) ((en)) Additional Information Here you can find the german version of the documentation.IAB-Betriebs-Historik-Panel, IAB-Beschäftigtenhistorik, IAB-Leistungsempfängerhistorik, Datenaufbereitung, Forschungsdatenzentrum, Arbeitsmarktforschung, Datenorganisation, Betrieb, Wirtschaftszweige, regionale Verteilung, Unternehmensgründung, Betriebsstilllegung, Beschäftigtenstruktur, sozialversicherungspflichtige Arbeitnehmer, erwerbstätige Frauen, Inländer, Ungelernte, Qualifikationsniveau, Bildungsabschluss, Schulbildung, Berufsausbildung, Studienabschluss, Fachhochschule, Hochschule, Vollzeitarbeit, Stellung im Beruf, Auszubildende, nicht formal Qualifizierte, Facharbeiter, Polier, Meister, Angestellte, Teilzeitarbeitnehmer, Heimarbeitnehmer, geringfügige Beschäftigung, Altersstruktur, Lohnstruktur, Lohnhöhe, Vollzeitarbeit, Nationalität, Jugoslawe, Osteuropäer, Pole, Spanier, Portugiese, Türke, Beschäftigtenstatistik
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