164,915 research outputs found
O kung Fu e o desenvolvimento infantil : desenvolvimento motor
No full textEste trabalho busca elementos para verificar a ligação do Kung Fu, uma arte
marcial chinesa, com o desenvolvimento motor infantil, baseando-se no conceito do
desenvolvimento motor de GALLAHUE, D. L.; OZMUN, J. C e MEINEL, K., e assim poder
associar estes conceitos a pratica desta, que atualmente é uma das artes marciais mais praticadas
no mundo. Mas antes de apresentar o desenvolvimento motor, passa-se por uma revisão da
história do Kung Fu, e uma revisão sobre o desenvolvimento, para que se possa desenvolver
com clareza a idéia da ligação das duas coisas. Durante a pesquisa foi realizado como forma de
busca de dados, um sistema de diário de observação de alunos praticantes de Kung Fu em
diversos níveis de aprendizagem e treinamento, respeitando a faixa etária proposta pelo trabalho,
para poder apresentar conclusões consistentes. Sem aprofundar-se no tipo de treinamento
realizado e nos estilos existentes da modalidade esportiva, mas se atentando exclusivamente as
crianças no treinamento, com os dados coletados, foi possível observar uma grande relação entre
o Kung Fu e a melhora do desenvolvimento de capacidades como coordenação motora geral,
equilíbrio, lateralidade, noção de direita e esquerda, posição e sentido.This paper searches for elements to verify the connection of Kung Fu, a
Chinese martial art, with the motor development of children, based on the concept of motor
development of GALLAHUE, D. L.; OZMUN, J. C e MEINEL, K., and this way be able to
associate these concepts to it, which is currently one of the most practiced martial arts in the
world. But before presenting the motor development, it will go through a review of the history
of Kung Fu, and a review about the development, so that it can develop a clear idea of the
connection of both things. During the research it was conducted as a way of data searching, a
system of observation journal of students practicing Kung Fu at different levels of learning and
training, respecting the age proposed for the work, to present consistent conclusions. Without
going too deep into the kind of training conducted and in the different existing styles of the
sport, but exclusively paying attention to the children in training, with the collected data, it was
possible to observe a strong relation between Kung Fu and the improvement of capacities as
general motor coordination, balance, laterality, sense of right and left, position and direction
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
No full textOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
Pygoluciola qingyu Fu et Ballantyne
No full textPygoluciola qingyu Fu et Ballantyne Figs 43–48, 63 – 4, 71, 92 Pygoluciola qingyu Fu et Ballantyne, 2008: 1. Material examined. CHINA: Eight fifth instar larvae, E Mei Mountain, Sichuan Province, July 8, 2006 (NHMHAU). Diagnosis. Very similar in morphology to larvae of L. gorhami, L. praeusta. L. terminalis, L. cerata, L. anceyi from which it differs most obviously in having 2 inner teeth on the mandibles (Figs 46, 71). Found near shallow bodies of water along road sides. Known to be actively predacious on living ants. Remarks. It is very possible that some of the other species with similar dorsal morphology, but a single toothed retinaculum, (e.g. L. gorhami, L. praeusta. L. terminalis, L. cerata, L. anceyi) could be found to be semiaquatic (Chen 2003; Fu & Ballantyne in prep.). There are however no records to suggest these species are actively predacious like P. qingyu. Chen (2003) recorded L. terminalis as terrestrial, the adults occurring close to rice fields, while L. praeusta was found alongside mountain roads in an environment that approaches that of Pygoluciola qingyu with larvae recorded as terrestrial. Fletcher (1919: 28) found L. gorhami in Pusa India under fallen and rotting leaves, indicated it fed only on dead Lepismidae (Thysanura), and would not touch living food. Mehta (1932) considered the spinose tergal plates equated with a burrowing mode of life.Published as part of Fu, Xinhua, Ballantyne, Lesley & Lambkin, Christine, 2012, The external larval morphology of aquatic and terrestrial Luciolinae fireflies (Coleoptera: Lampyridae), pp. 1-34 in Zootaxa 3405 on page 20, DOI: 10.5281/zenodo.21130
Aquatica Fu, Ballantyne & Lambkin, 2010, gen. nov.
No full textKey to species of Aquatica gen. nov. 1. Dorsally pale ................................................................................................................................ leii (Fu et Ballantyne) - Dorsal surface always with dark brown elytra which may be pale margined.............................................................. 2 2. Pronotum with median dark marking........................................................................................................................... 3 - Pronotum lacking median dark marking....................................................................................................................... 4 3. Pronotum reddish with median dark marking extending from anterior to posterior margins; aedeagus with inner basal area of LL (view from above) toothed ..................................................................................... lateralis (Motsch.) - Pronotum yellowish with median dark marking not extending to posterior margin; aedeagus with inner basal area of LL not toothed ....................................................................................................................................... wuhana sp. nov. 4. Elytra with narrow pale band along suture, and lateral margins narrowly paler than rest; posterior area of aedeagal sheath sternite may appear strongly bent to right; inner margins of LL apices hooked .......................... ficta (Olivier) - Elytra dark brown with no paler lateral margins; posterior area of aedeagal sheath sternite not bending strongly to right; inner margins of LL apices not hooked ............................................................................ hydrophila (Jeng et al.)Published as part of Fu, Xinhua, Ballantyne, Lesley & Lambkin, Christine L., 2010, Aquatica gen. nov. from mainland China with a description of Aquatica Wuhana sp. nov. (Coleoptera: Lampyridae: Luciolinae), pp. 1-18 in Zootaxa 2530 on pages 5-6, DOI: 10.5281/zenodo.19653
EpCAM Aptamer Activated 5-FU-Loaded PLGA Nanoparticles in CRC Treatment; In vitro and In vivo study
No full textIn this study, EpCAM aptamer-activated nanoparticles (Ap-NPs) were synthesized to enhance treatment efficiency in colorectal cancer (CRC). PLGA [poly (D, L-lactide-co-glycolide)] copolymer was fabricated by conjugation of COOH-PEG-NH2 to PLGA-COOH through an EDC/NHS-mediated chemistry. Afterward, 5‐fluorouracil-loaded (FU) nanoparticles were prepared using the water/oil/water double emulsion solvent evaporation method. The in vitro cytotoxicity of formulations was evaluated using the MTT assay in HCT-116, CT-26, and HEK-293 cell lines. For in vivo study, tumor-bearing BALB/c mice were established by subcutaneous injection of CT-26 cell line. The results indicated that fabricated AP-FU-NPs had 101 nm size with a spherical surface, relatively homogeneously and, satisfactory encapsulation efficiency (83.93%). In vitro experiments revealed that Ap-FU-NPs had a superior in vitro cytotoxicity than both FU-NPs and free 5-FU in CT-26 and HCT-116 cells but, were significantly low toxic against HEK-293 cells relative to free 5-FU. Furthermore, in vivo results showed no significant hemolytic effect, hepatic and renal injury, or weight loss. After treatment of various animal groups with formulations, notable tumor growth delay was observed followed the order: Ap-FU-NPs The overall strategy of this study is summarized in Graphical Abstract. The present study was carried out in the three steps summarized: 1) synthesis and characterization. At first, PEG was conjugated to PLGA polymers by EDC/NHS chemistry method, then the resulting polymers were used to prepare PLGA-PEG NPs via the W/O/W technique. Finally, EpCAM Aptamers were attached to fabricated NPs. 2) In the second step cytotoxicity of formulated NPs was evaluated in vitro experiments in HEK-293, CT-26, and HCT-116 cell lines. 3) In the third step in vitro results further was investigated in CT-26 tumor-bearing BALB/c mice. “Created with BioRender.com.”</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Practical application of on-line partial discharge monitoring technique on 500kV shunt reactor
No full textConsidering the damage mechanism of oil-impregnated paper insulation in power transformers, shunt reactors and other high voltage electrical apparatus caused by partial discharge, a concept of “destructive partial discharge” is introduced in this paper. The intensity of this discharge is regarded as several thousands pico-coulomb (pC) and may cause the insulation a fatal damage. An oil-paper insulation is usually able to withstand this type of partial discharge for a period of time prior to failure. This provides engineers a time window to detect it. This paper describes an on-line partial discharge monitoring system for 500kV shunt reactors. The commission results from 3 single-phase shunt reactors either connected or disconnected to the grid showed that the on-line partial discharge detecting system has a high noise immunising ability. Two years later after the installation, a pre-warning signal was received from one shunt reactor indicating the existence of an intermittent discharge. The acoustic emission system located its position at the low end of the high voltage bushing in the oil. Dissolved gasses analysis (DGA) in the oil suggested the presence of partial discharge, as acetylene (C2H2) was as high as 20ppm. PD activity was further confirmed by a physical examination on the reactor
Gemcitabine: Progress in the treatment of pancreatic cancer
No full textUnresectable pancreatic cancer has a dismal prognosis with a median survival of 3-5 months in untreated disease. Since the introduction of gemcitabine, pancreatic cancer may no longer be regarded a chemotherapy-resistant tumor. Treatment with single-agent gemcitabine achieved clinical benefit and symptoms improvement in 20-30% of patients. While 1-year survival was observed in 2% of 5-fluorouracil (5-FU)-treated patients, it was raised to 18% by single-agent gemcitabine. Good treatment tolerability and low incidence of side effects are clear advantages of single-agent gemcitabine. Improvement of efficacy is, however, expected from combination treatment. Gemcitabine and cisplatin given as first-line treatment in three studies achieved a median survival of 7.4-8.3 months. One-year survival was raised to 28% as reported in one study. Comparable activity was obtained by a combination of gemcitabine with 5-FU. Nine studies using gemcitabine in combination with standard-dose or high-dose 5-FU reported a median survival ranging from 5.5 to 13 months. Notwithstanding these promising results, recommendations regarding palliative chemotherapy of pancreatic cancer remain tentative and still need confirmation by presently ongoing phase III trials. Inclusion of pancreatic cancer patients into clinical trials should be a major goal. Outside clinical trials, patients should present with an adequate PS (Karnofsky-performance index greater than or equal to 70) to qualify for chemotherapy. Copyright (C) 2001 S. Karger AG, Basel
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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