154,093 research outputs found
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
No full textOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
Note of congratulations from Jack Huang to Dr. Frank Fu, January 1, 1983
No full textA note of congratulations to Dr. Frank H. Fu (Fu Haojian) from Springfield College Alum, Jack Huang, Class of 1936, dated January 1, 1983. The card has country lane scene on the front, with a tree with pink leaves, a buttfly, and a tree with its leaves still green. There is the roof of a house just visible over the hill. It also says Congratulations. Inside is short message.Mr. Huang wrote a short personal note congratulating him for his efforts and the recent recognition by then President Ronald Reagan, or the actor as he refers to him, and saying how proud the Chinese are of him. An author of 17 textbooks and more than 100 journal articles, Frank H. Fu, G’73, DPE’75, has worked across the world in China, Canada, and the United States. Throughout his career, he has received many distinguished honors, including the Medal of Honor in 2009 by the SAR Government of Hong Kong.
Fu has held positions at institutions such as the Chinese University of Hong Kong and Springfield College, where he served as director of the International Center starting in 1978. Five years later, Fu returned to Hong Kong, but has since remained actively involved with Springfield College, participating in talks on the campus and even hosting a gathering of nearly 60 alumni in Hong Kong.
Currently, Fu is the associate vice president of Hong Kong Baptist University, where he also works as the director of the Dr. Stephen Hui Research Centre of Physical Recreation and Wellness. In addition, Fu is president of the Society of Chinese Scholars on Exercise Physiology and Fitness, chairperson of Hong Kong Coach Education Committee, a research fellow of the Research Consortium of SHAPE America, and an international fellow of the National Academy of Kinesiology
Dr. Frank Fu
No full textA portrait photograph of Dr. Frank H. Fu (Fu Haojian). The writing on the photograph says "17 yrs."An author of 17 textbooks and more than 100 journal articles, Frank H. Fu, G’73, DPE’75, has worked across the world in China, Canada, and the United States. Throughout his career, he has received many distinguished honors, including the Medal of Honor in 2009 by the SAR Government of Hong Kong.
Fu has held positions at institutions such as the Chinese University of Hong Kong and Springfield College, where he served as director of the International Center starting in 1978. Five years later, Fu returned to Hong Kong, but has since remained actively involved with Springfield College, participating in talks on the campus and even hosting a gathering of nearly 60 alumni in Hong Kong.
Currently, Fu is the associate vice president of Hong Kong Baptist University, where he also works as the director of the Dr. Stephen Hui Research Centre of Physical Recreation and Wellness. In addition, Fu is president of the Society of Chinese Scholars on Exercise Physiology and Fitness, chairperson of Hong Kong Coach Education Committee, a research fellow of the Research Consortium of SHAPE America, and an international fellow of the National Academy of Kinesiology.Photograph is stapled with other photographs to folder of original student record kept by the International center
Dr. Frank Fu thinking
No full textA photograph of Dr. Frank H. Fu (Fu Haojian). He is seated with hands held up to his chin and appears to be deep in thought. There are others around him, but they are unable to be seen clearly enough to identify.An author of 17 textbooks and more than 100 journal articles, Frank H. Fu, G’73, DPE’75, has worked across the world in China, Canada, and the United States. Throughout his career, he has received many distinguished honors, including the Medal of Honor in 2009 by the SAR Government of Hong Kong.
Fu has held positions at institutions such as the Chinese University of Hong Kong and Springfield College, where he served as director of the International Center starting in 1978. Five years later, Fu returned to Hong Kong, but has since remained actively involved with Springfield College, participating in talks on the campus and even hosting a gathering of nearly 60 alumni in Hong Kong.
Currently, Fu is the associate vice president of Hong Kong Baptist University, where he also works as the director of the Dr. Stephen Hui Research Centre of Physical Recreation and Wellness. In addition, Fu is president of the Society of Chinese Scholars on Exercise Physiology and Fitness, chairperson of Hong Kong Coach Education Committee, a research fellow of the Research Consortium of SHAPE America, and an international fellow of the National Academy of Kinesiology
Dr. Frank Fu, c. 1979
No full textA portrait photograph of Dr. Frank H. Fu (Fu Haojian). The photograph was used in news stories on Dr. Fu for his work and his appointment as Director of Springfield College's International Center.An author of 17 textbooks and more than 100 journal articles, Frank H. Fu, G’73, DPE’75, has worked across the world in China, Canada, and the United States. Throughout his career, he has received many distinguished honors, including the Medal of Honor in 2009 by the SAR Government of Hong Kong.
Fu has held positions at institutions such as the Chinese University of Hong Kong and Springfield College, where he served as director of the International Center starting in 1978. Five years later, Fu returned to Hong Kong, but has since remained actively involved with Springfield College, participating in talks on the campus and even hosting a gathering of nearly 60 alumni in Hong Kong.
Currently, Fu is the associate vice president of Hong Kong Baptist University, where he also works as the director of the Dr. Stephen Hui Research Centre of Physical Recreation and Wellness. In addition, Fu is president of the Society of Chinese Scholars on Exercise Physiology and Fitness, chairperson of Hong Kong Coach Education Committee, a research fellow of the Research Consortium of SHAPE America, and an international fellow of the National Academy of Kinesiology
Dr. Frank H. Fu receiving award
No full textThis photograph shows Dr. Frank H. Fu, the Director of Springfield College's International Center, holding an award with two men on each side of him. 傅浩堅; 傅浩坚;He became Springfield's director in 1978 and stayed until 1983. As the director, he coordinated the activities and programs of the Doggett Memorial International Center. Dr. Fu received a diploma and certificate from St. Paul's College in Hong Kong in 1968 and a Bachelor's degree from Dartmouth College in 1971. He was then awarded a Master's degree from Springfield College in 1973, and a Doctorate in Physical Education from Springfield in 1975. In 1979, Dr. Fu visited Hong Kong to lecture students on physical education programs and the differences among them from country to country. He worked to promote and establish foreign exchange programs
Otacilia jianfengling Fu, Zhang & Zhu 2010
No full text<i>Otacilia jianfengling</i> Fu, Zhang & Zhu, 2010 (Figs 52–58) <p> <i>Otacilia jianfengling</i> Fu, Zhang & Zhu, 2010: 641, f. 1A–H, 2A–E.</p> <p>Material examined. Holotype ♂, paratypes 1♂, 4♀, China, Hainan Province, Ledong County, Mt. Jianfengling (18.61°N, 108.93°E), 9 August 1980, Ming-Sheng Zhu leg. Other materials. China, Hainan Province, Ledong County, Mt. Jianfengling, Tianchi Lake (18°44′25″N, 108°51′44″E), 2♂, 3♀, 31 January 2015, Li-Na Fu leg.; Jianfengling National Forest Park (18°44′27″N, 108°51′36″E), 4♂, 4♀, 1 February 2015, Chi Jin leg.</p> <p>Description. See Fu, Zhang & Zhu (2010). Male (holotype) habitus shown in Fig. 52, male palp in Figs 54–56; female (paratype) habitus in Fig. 53, epigyne and vulva in Figs 57–58.</p> <p>Distribution. China (Hainan).</p>Published as part of <i>Fu, Li-Na, He, Jing-Chao & Zhang, Feng, 2015, Species of the genus Otacilia from Hainan Island, China (Araneae: Phrurolithidae), pp. 436-450 in Zoological Systematics 40 (4)</i> on page 448, DOI: 10.11865/zs.20150402, <a href="http://zenodo.org/record/4617522">http://zenodo.org/record/4617522</a>
Gemcitabine: Progress in the treatment of pancreatic cancer
No full textUnresectable pancreatic cancer has a dismal prognosis with a median survival of 3-5 months in untreated disease. Since the introduction of gemcitabine, pancreatic cancer may no longer be regarded a chemotherapy-resistant tumor. Treatment with single-agent gemcitabine achieved clinical benefit and symptoms improvement in 20-30% of patients. While 1-year survival was observed in 2% of 5-fluorouracil (5-FU)-treated patients, it was raised to 18% by single-agent gemcitabine. Good treatment tolerability and low incidence of side effects are clear advantages of single-agent gemcitabine. Improvement of efficacy is, however, expected from combination treatment. Gemcitabine and cisplatin given as first-line treatment in three studies achieved a median survival of 7.4-8.3 months. One-year survival was raised to 28% as reported in one study. Comparable activity was obtained by a combination of gemcitabine with 5-FU. Nine studies using gemcitabine in combination with standard-dose or high-dose 5-FU reported a median survival ranging from 5.5 to 13 months. Notwithstanding these promising results, recommendations regarding palliative chemotherapy of pancreatic cancer remain tentative and still need confirmation by presently ongoing phase III trials. Inclusion of pancreatic cancer patients into clinical trials should be a major goal. Outside clinical trials, patients should present with an adequate PS (Karnofsky-performance index greater than or equal to 70) to qualify for chemotherapy. Copyright (C) 2001 S. Karger AG, Basel
Targeted Drug Delivery to Chemoresistant Cells: Folic Acid Derivatization of FdUMP[10] Enhances Cytotoxicity toward 5-FU-Resistant Human Colorectal Tumor Cells.
No full textTargeted Drug Delivery to Chemoresistant Cells: Folic Acid Derivatization of FdUMP[10] Enhances
Cytotoxicity toward 5-FU-Resistant Human Colorectal Tumor
Cells
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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