2,719,378 research outputs found
Shanxi province (China), people irrigating from a well on the Taiyuan plain
No full textIrrigating from a well on the Taiyuan Plain.Image is part of research conducted by Raymond T. Moyer for the article: Agricultural Soils in a Loess Region of North China
Author(s): Raymond T. Moyer
Source: Geographical Review, Vol. 26, No. 3 (Jul., 1936), pp. 414-425
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/209047http://www.jstor.org/stable/209047Grayscal
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Letter from Stephen T. Mather to Carl Hayden
No full textLetter from Stephen T. Mather to Carl T. Hayden thanking Hayden for his advice about visiting Arizon
Letter from Stephen T. Mather to Carl Hayden
No full textLetter from Stephen T. Mather to Carl T. Hayden advocating for a reduction in automobile fees for the South Rim entrance
Shanxi (China), red soil basin around Qin Xian
No full textTopography in the red soil basin around Chinchow.Image is part of research conducted by Raymond T. Moyer for the article: Agricultural Soils in a Loess Region of North China
Author(s): Raymond T. Moyer
Source: Geographical Review, Vol. 26, No. 3 (Jul., 1936), pp. 414-425
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/209047http://www.jstor.org/stable/209047Grayscal
Produktivität und Futterqualität von bewirtschaftetem, naturnahem Grünland unterschiedlicher Phytodiversität
No full textProduktivität und Futterqualität von bewirtschaftetem, naturnahem Grünland unterschiedlicher Phytodiversität
No full textShanxi (China), profile of soils
No full textProfile of soils of the Gray Brown Subgroup, showing zone of accumulation.Image is part of research conducted by Raymond T. Moyer for the article: Agricultural Soils in a Loess Region of North China
Author(s): Raymond T. Moyer
Source: Geographical Review, Vol. 26, No. 3 (Jul., 1936), pp. 414-425
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/209047http://www.jstor.org/stable/209047Grayscal
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
