100,587 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Cochlear Implants: bridging the gap between computational model and clinic
No full text The work of this thesis was to develop and use such a computational model to offer insight into the working mechanisms of cochlear implant stimulation and to enable virtual experiments that would be unfeasible or outright impossible in real life. The model that was used for this thesis was not built from scratch but was an updated and expanded version of the one developed at Leiden University Medical Centre by Johan H.M. Frijns and Jeroen J. Briaire. In essence, this thesis forms a continuation of their PhD work. The general goals of each of the modelling studies presented in this thesis were:(I) To improve the accuracy of the Leiden computational cochlear implant model to gain a better understanding of cochlear implant-induced hearing.(II) Where possible, validate the model using available data from electrophysiological or psychophysical experiments.(III) To use the model to offer predictions that may help to improve the function or design of cochlear implants in the future. </p
Cochlear Implants: bridging the gap between computational model and clinic
No full text The work of this thesis was to develop and use such a computational model to offer insight into the working mechanisms of cochlear implant stimulation and to enable virtual experiments that would be unfeasible or outright impossible in real life. The model that was used for this thesis was not built from scratch but was an updated and expanded version of the one developed at Leiden University Medical Centre by Johan H.M. Frijns and Jeroen J. Briaire. In essence, this thesis forms a continuation of their PhD work. The general goals of each of the modelling studies presented in this thesis were:(I) To improve the accuracy of the Leiden computational cochlear implant model to gain a better understanding of cochlear implant-induced hearing.(II) Where possible, validate the model using available data from electrophysiological or psychophysical experiments.(III) To use the model to offer predictions that may help to improve the function or design of cochlear implants in the future. </p
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Surveys on user types, availability and consumption estimates
No full textThe main aims of this study were three-fold: to describe characteristics of users and consumption patterns among different
types of users of cannabis, ecstasy, amphetamines, cocaine and heroin; secondly, to describe the availability of drugs to the
different types of users; and thirdly, to make estimates of the amount of drugs consumed - by user type and in total - in
the seven sample EU Member States: Bulgaria, the Czech Republic, Italy, the Netherlands, Portugal, Sweden and England &
Wales. In Spring 2012 a web survey was carried out in the seven countries to collect data on these topics for the four drugs
under study. For the Czech Republic, amphetamine in this report refers to methamphetamine
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Hearing status affects children's emotion understanding in dynamic social situations: An eye-tracking study.
No full textTsou, Y. T., Li, B., Kret, M. E., Frijns, J. H. M., & Rieffe, C. (2021?). Ear and Hearing
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