306,193 research outputs found
Frew, E A, NX28525
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/386391Surname: FREW. Given Name(s) or Initials: E A. Military Service Number or Last Known Location: NX28525. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 36748.208161
Item: [2016.0049.18684] "Frew, E A, NX28525
Sublingual immunotherapy
No full textRecent claims have been made that sublingual immunotherapy (SLIT) may be a viable alternative to injection immunotherapy (SIT). Animal studies show that when allergens are administered topically, they are handled differently, and IgE responses can be reduced. Most published studies of human SLIT have been small but show fairly consistent benefits on symptom scores, with few systemic side effects. Objective measures of allergen reactivity usually do not change. Relatively few subjects have been treated in SLIT trials compared with the numbers that would be required to validate new drug therapies. On the plus side, SLIT appears to work in adults and in children; it offers some logistic advantages and seems to be safe. Giving allergen by mouth rather than by injection should decrease the costs of immunotherapy, but the cumulative dose of allergen used in SLIT has been between 20 to 375 times the dose given in conventional SIT. Further cost-benefit analysis is needed. On the other hand, standard SIT is effective and is supported by better clinical and experimental evidence. The balance sheet for SLIT is improving, but on the current evidence, SLIT requires further evaluation before it could be recommended for use in routine clinical practice
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
GA2LEN--The Global Allergy and Asthma European Network
No full textThe European Community's Network on Allergies and Asthma was launched officially on 12 February 2004 in the presence of the European Commissioner Phillipe Bousquin. The current round of European Union funding for research includes two major new types of funding vehicle: integrated projects and networks of excellence. GA2LEN represents one of the first networks of excellence to be put into play by the European Commission, and Commissioner Bousquin was careful to point out that as well as addressing a major public health problem in Europe, the new network should serve as a standard bearer for this new form of European funding and research co-operation. So, what lies beyond the political rhetoric? Why do we need a European Network at this time and what does it hope to achieve during the 5 years of its life? Everyone agrees that allergic diseases such as asthma, allergic rhinitis (AR) and eczema have all increased over the last 30–40 years [1]. The European country with the highest prevalence of allergic disease is the UK where up to 32% of 13–14-year-olds report symptoms of asthma. While the prevalence rates vary between different European countries, the general upward trend is universal, making this a concern for all Europeans. Despite recent evidence that there has been a levelling off of the rate of asthma and related conditions in the UK [2], there remain worries that the prevalence rates could start to rise again in the UK and of course other countries have no wish to emulate the rates of asthma and allergic disease that are seen in the UK. Asthma is a major factor in children losing days from school, with potential consequences for their level of educational achievement while in adults asthma is an important cause of absence from the workplace. Besides the personal inconvenience, this represents a significant loss of productivity, and some estimates are as high as 9 billion working days lost because of asthma each year in the European Union. Asthma has direct medical costs in the form of medication and hospital care, with about 5% of the European medication budget currently being spent on caring for asthma. AR and eczema may not cause so many admissions to hospital as asthma but they also consume considerable amounts of healthcare resources in the form of medication
There's a garden in the heart of Switzrland
No full textFor voice and piano.Caption title.Illustrated list t.p. in pink, white and gold with a drawing of a lamp, fan, mask, goblet and fleur-de-lis / Frew; list of 11 selections from the show."Songs from Lew Fields production The pleasure seekers produced at the New York Winter Garden / book by Edgar Smith ; lyrics & music by E. Ray Goetz"--List title page.Archived web conten
Advances in environmental and occupational disorders
No full textThe environment plays a crucial role in determining the development and expression of allergic disorders. Epidemiologic studies allow us to understand risk factors for allergic disease, which may lead to interventional studies to provide the evidence base for our clinical advice. Articles published in The Journal of Allergy and Clinical Immunology last year highlighted the relevance of mold exposure and environmental tobacco smoke as risk factors for the development of asthma and the expression of symptoms. The role of fitted carpets as a reservoir for house dust allergens was also challenged by data arising from this work. Occupational allergy is an important clinical and socioeconomic problem. A large body of work on latex allergy has been reported in the past year, demonstrating the impact of containment strategies on exposure to latex and the incidence of sensitization to latex. Other articles have explored the range of latex allergens to which patients are sensitized and the HLA associations of latex allergy. Two models of isocyanate sensitization were reported, providing some insight into possible mechanisms of isocyanate asthma and some clues for understanding nonallergic asthma. Environmental and occupational disorders are highly relevant to our readership, and the new Editorial Board hopes to encourage submission and publication of relevant articles in this area
Advances in environmental and occupational diseases 2004
No full text2004 was another good year for publications on environmental and occupational disorders in our journal. The major focus is clearly on the environment and particularly on environmental risk factors for sensitization and asthma. There is a growing consensus that exposure to pets is good, provided there is enough of it. Low levels enhance sensitization, and higher levels protect against the consequences of that sensitization. Following on from previous work on cockroaches, we now see allergy to feral mice as an emergent problem—at least we now have the tools to study this properly. Emphasis seems to be swinging away from the outdoor environment as a cause of allergic disease and toward the indoor environment, which is, after all, where most of us spend most of our lives. New techniques for studying isocyanate allergy might kindle a revival of interest in the mechanisms of occupational asthma caused by low-molecular-weight compounds. But for all types of occupational allergy, prevention remains key, and it is good to see that comprehensive programs of allergen reduction can pay off in reduced rates of latex allergy in health care workers. Further work in the area of recombinant allergens is welcome but needs soon to be translated into new diagnostic and therapeutic strategies. This sector of allergy research remains vibrant, and the editors will continue to welcome outstanding contributions in this area
25. Immunotherapy of allergic disease
No full textSpecific immunotherapy involves the administration of allergen extracts to achieve clinical tolerance of the allergens which cause symptoms in patients with allergic conditions. Immunotherapy has been shown to be effective in patients with mild forms of allergic disease, and also in those who do not respond well to standard drug therapy. Recent studies suggest that specific immunotherapy may also modify the course of allergic disease, by reducing the risk of developing new allergic sensitizations, and also inhibiting the development of clinical asthma in children treated for allergic rhinitis. Specific immunotherapy remains the treatment of choice for patients with systemic allergic reactions to wasp and bee stings. The precise mechanisms responsible for the beneficial effects of SIT remain a matter of research and debate. An effect on regulatory T cells seems most probable, associated with switching of allergen-specific B cells towards IgG4 production. Few direct comparisons of specific immunotherapy and drug therapy have been made. Existing data suggest that the effects of specific immunotherapy take longer to come on, but once established, specific immunotherapy will give long-lasting relief of allergic symptoms, whereas the benefits of drugs only last as long as they are continued. (J Allergy Clin Immunol 2003;111:S712-9.
What can we learn about asthma from studying occupational asthma?
No full textObjective: To review the clinical features and underlying mechanisms of occupational asthma in an attempt to glean insights into various other forms of asthma.Data Sources: Published literature, including consensus guidelines on diagnosis and management of occupational asthma.Study Selection: This article represents a synthesis of these data sources and the opinion of the author.Results: Occupational asthma may be caused by a variety of mechanisms, including both IgE-dependent and non-IgE-dependent immunological processes. IgE-dependent mechanisms are responsible for reactions to all high-molecular-weight occupational antigens and to some but not all low-molecular-weight antigens. Factors in sensitization and onset include the general genetic predisposition to make IgE and the specific responsiveness of the individual to particular allergens. Once sensitized, the main factor that influences the onset of symptoms is the degree of exposure. In general, the higher the level of exposure, the more likely the sensitized person is to develop asthma.Conclusions: Occupational asthma can be induced by a variety of agents that appear to use different mechanisms to affect the airway. Studies of the remission of occupational asthma indicate that resolution is a slow process. However, the study of occupational asthma may eventually allow us to identify treatments that will accelerate remission or induce remission in other forms of asthma
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