323,966 research outputs found
Nuova generazione di frese diamantate al rodio-platino
No full textLo studio eseguito intende analizzare alcune caratteristiche determinanti nella risultanza clinica di strumenti abrasivi rotanti realizzati con componenti innovativi. Dall’analisi delle informazione tecniche le frese di nuova generazione appaiono evidentemente migliori rispetto alle frese tradizionali: in particolare ad un più elevato potere di taglio e una maggior durata nel tempo si associa un’ottima biocompatibilità, con vantaggi sia per l’operatore che per il paziente stesso
[Rezension zu:] Tobias Frese; Aktual- und Realpräsenz. Das eucharistische Christusbild von der Spätantike bis ins Mittelalter (Neue Frankfurter Forschungen zur Kunst, Bd. 13); hrsg. vom Kunstgeschichtlichen Institut der Goethe-Universität Frankfurt am Main; Berlin: Gebr. Mann Verlag 2013; 290 S., 80 Abb., davon 18 in Farbe; ISBN 978-3-7861-2693-5
No full textVersteht man das christlich religiöse Bild als einen wesentlichen Bestandteil der europäischen Kunst, berührt die Frage nach seinen Anfängen die Grundlagen der gesamten nachantiken Kunst Europas. Tobias Frese erörtert in seiner Studie ein Problem, das für das christliche Bild von zentraler Bedeutung war: den Wandel von der "pneumatische[n] Gottesvorstellung" des zumindest bilderskeptischen frühen Christentums hin zum konkret körperlich gedachten Gottessohn, der in der Eucharistie gegenwärtig wird; er betont die große Bedeutung der "Vorstellung von der 'Aktual' und 'Realpräsenz' [...] für die Entwicklung des frühen Christusbildes". ..
Arylsulfatase G, a novel lysosomal sulfatase
No full textFrese M-A, Schulz S, Dierks T. Arylsulfatase G, a novel lysosomal sulfatase. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(17):11388-11395.The sulfatases constitute a conserved family of enzymes that specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. By modifying the sulfation state of their substrates, sulfatases play a key role in the control of physiological processes, including cellular degradation, cell signaling, and hormone regulation. The loss of sulfatase activity has been linked with various severe pathophysiological conditions such as lysosomal storage disorders, developmental abnormalities, or cancer. A novel member of this family, arylsulfatase G (ASG), was initially described as an enzyme lacking in vitro arylsulfatase activity and localizing to the endoplasmic reticulum. Contrary to these results, we demonstrate here that ASG does indeed have arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. The activity of ASG depends on the Cys-84 residue that is predicted to be post-translationally converted to the critical active site C-alpha-formylglycine. Phosphate acts as a strong, competitive ASG inhibitor. ASG is active as an unprocessed 63-kDa monomer and shows an acidic pH optimum as typically seen for lysosomal sulfatases. In transfected cells, ASG accumulates within lysosomes as indicated by indirect immunofluorescence microscopy. Furthermore, ASG is a glycoprotein that binds specifically to mannose 6-phosphate receptors, corroborating its lysosomal localization. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ASG that might be associated with a so far non-classified lysosomal storage disorder
John Beckford teaching Marcella Frese
No full textJohn S. Beckford, Professor of Music, teaching marimba to Marcella Frese, Class of 1984, on the Daniel Recital Hall stage. John Beckford joined the Furman faculty in 1976. After 32 years as the university's first full-time percussion instructor, he was appointed dean of faculty in March 2008 and later became vice president for academic affairs and dean, the university's chief academic officer. Dean Beckford retired in 2019
Metodiche di prelievo osseo intraorale: frese carotatrici K-System
No full textGli innesti di osso da siti intraorali prevedono il prelievo di osso solo corticale, di tasselli o carote ossee corticomidollari o di bone chip. Qualunque sia la tecnica prescelta essa deve essere possibilmente semplice e poco traumatica, specialmente in caso di prelievi di piccole dimensioni. In tale panorama ben si inseriscono le frese carotatici K-System che delineano il blocco del prelievo e contemporaneamente lo triturano con una lama rotante interna alla fresa: il prelievo particolato che si ottiene può essere utilizzato a fini chirurgico-implantologici con sicurezza, non essendo contaminato dalla saliva
Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling
No full textLamanna WC, Frese M-A, Balleininger M, Dierks T. Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(41):27724-27735.Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival. In this study, the mammalian Sulfs were functionally characterized using overexpressing cell lines, in vitro enzyme assays, and in vivo Sulf knock-out cell models. Analysis of subcellular Sulf localization revealed significant differences in enzyme secretion and detergent solubility between the human isoforms and their previously characterized quail orthologs. Further, the activity of the Sulfs toward their native heparan sulfate substrates was determined in vitro, demonstrating restricted specificity for S-domain-associated 6S disaccharides and an inability to modify transition zone-associated UA-GlcNAc( 6S). Analysis of heparan sulfate composition from different cell surface, shed, glycosylphosphatidylinositol- anchored and extracellular matrix proteoglycan fractions of Sulf knock-out cell lines established differential effects of Sulf1 and/or Sulf2 loss on nonsubstrate N-, 2-O-, and 6-O-sulfate groups. These findings indicate a dynamic influence of Sulf deficiency on the HS biosynthetic machinery. Real time PCR analysis substantiated differential expression of the Hs2st and Hs6st heparan sulfate sulfotransferase enzymes in the Sulf knock-out cell lines. Functionally, the changes in heparan sulfate sulfation resulting from Sulf loss were shown to elicit significant effects on fibroblast growth factor signaling. Taken together, this study implicates that the Sulfs are involved in a potential cellular feed-back mechanism, in which they edit the sulfation of multiple heparan sulfate proteoglycans, thereby regulating cellular signaling and modulating the expression of heparan sulfate biosynthetic enzymes
The psychology of entrepreneurial performance-theoretical and applied : Robert A. Baron and Michael Frese, co-recipients of the 2024 Global Award for Entrepreneurship Research
No full textProfessors Robert A. Baron and Michael Frese are the joint recipients of the 2024 Global Award for Entrepreneurship Research. Their research contributions have helped establish the disciplinary foundation necessary to explore entrepreneurship from theoretical and applied psychological perspectives. From a theoretical psychological perspective, Professor Baron has repeatedly introduced a disciplinary scaffolding from cognitive psychology, social psychology, and judgment and decision-making psychology to develop the field's socio-cognitive perspective. He has examined entrepreneurship's basic "why" questions: (1) Why do some persons but not others choose to become entrepreneurs? (2) Why do some persons but not others recognize opportunities for new products or services that can be profitably exploited? (3) Why are some entrepreneurs so much more successful than others? From an applied psychological perspective, Professor Frese has examined entrepreneurship as the epitome of a proactive approach to work, advocating the benefits of personal initiative and the need for a self-regulatory approach to performance among both small business owners and employees in transition economies. Continually taking stock of what is known about the psychology of entrepreneurship through reviews and meta-analysis, he and his students have advanced an evidence-based approach to entrepreneurial training and performance in challenging contexts. Together, Professors Baron and Frese have served as ambassadors for the field of entrepreneurship, welcoming an entire generation of micro scholars to explore the entrepreneurial process and the psychology of the entrepreneurs who enact it
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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