400 research outputs found
Using omics in chronic pain conditions to delineate mechanisms and provide new therapeutic strategies
No full text170226 ELDER CARE EVENT BEARD 007
No full textProfessor Laura Olson, a member of the Political Science department at Lehigh, listens to her audience on Wednesday, Feb. 22, 2017 in Williams Hall. Olson is the author of "Elder Care Journey: A View from the Front Lines" (Maxim Beard/B&W Staff
170226 ELDER CARE EVENT BEARD 003
No full textProfessor Laura Olson, author of "Elder Care Journey: A View from the Front Lines", talks during a Brown Bag Series on Wednesday, Feb. 22, 2017 in Williams Hall. Olson is a professor of Political Science at Lehigh. (Maxim Beard/B&W Staff
170226 ELDER CARE EVENT BEARD 005
No full textProfessor Laura Olson, author of "Elder Care Journey: A View from the Front Lines", speaks during a Brown Bag Series on Wednesday, Feb. 22, 2017 in Williams Hall. Olson passionately discussed her personal experience with the long-term care system in the U.S. (Maxim Beard/B&W Staff
The Association Between Low Back Pain and Composition of IgG Glycome
Full text linkLow back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out a first so far analysis of associations between LBP and plasma IgG N-glycome in a sample of 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, and IgG-glycan levels. Using weighted correlation network analysis, we established a correlation between LBP and glycan modules featured by glycans that either promote or block antibody-dependent cell-mediated cytotoxicity (ADCC). The levels of four glycan traits representing two of those modules were statistically significantly different in monozygotic twins discordant for LBP. Also, the trend to higher prevalence of systemic inflammatory disorders was shown for twins with low level of fucosylated glycans and high level of non-fucosylated glycans. Core fucosylation of IgG is a "safety switch" reducing ADCC, thus our results suggest the involvement of ADCC and associated inflammation in pathogenesis of LBP. No correlation between LDD scores and glycans was found assuming that the inflammation may not be a part of LDD. These data provide a new insight into understanding the complex pathophysiology of LBP and suggest glycan levels as a possible biomarker for inflammation-related subtypes of LBP
Genome-wide association summary statistics for sex- and age-specific analysis of chronic back pain
No full textThe dataset comprises summary-level statistics for age- and sex-specific genome-wide association study of chronic back pain (cBP) in individuals of European descent from UK Biobank (https://www.ukbiobank.ac.uk/). The study was carried out under UK Biobank approved project #18219.
The dataset accompanies the paper (please cite if using the dataset):
Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; Meng, Weihua; Hayward, Caroline; Smith, Blair H.; Khoury, Samar; Parisien, Marc; Bortsov, Andrey; Diatchenko, Luda; Børte, Sigrid; Winsvold, Bendik S.; Brumpton, Ben M.; Zwart, John-Anker; HUNT All-In Pain; Aulchenko, Yurii S.; Suri, Pradeep; Williams, Frances M.K. Sex- and age-specific genetic analysis of chronic back pain. Pain. 2020. doi:10.1097/j.pain.0000000000002100.
The phenotype of cBP was defined as back pain for 3+ months. Linear mixed-effects additive model was fitted adjusting for age, genotyping array type, and 10 genetic PCs provided by UK Biobank. The following filters were applied: minor allele frequency >0.001, genotyping and individual call rates >0.98%, imputation quality score (INFO) >0.7. GWAS were carried out in males and females separately in the whole sample (allages) as well as in groups of younger than 65 years (under65) and 65+ years old (65plus) as detailed in the paper. Accordingly, 6 files are deposited here, corresponding to each group.
Column headers:
SNP, SNP rsID
CHR, chromosome
BP, genomic position (GRCh37 build)
EA, effect allele (coded as "1")
OTHER, other allele (coded as "0")
A1FREQ, frequency of effect allele
INFO, imputation quality
BETA, effect size (for effect allele)
SE, standard error of effect size
PVAL, p-value for associatio
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
No full textEpitaxial Zintl aluminide SrAl4 grown on a LaAlO3 substrate
Full text linkabstract: Zintl phases are a class of intermetallic materials that have simultaneously ionic and covalent bonding resulting from charge transfer between two different atomic species. We present a combined first principles and experimental study of Zintl-phase SrAl4, which is grown in thin film form on the perovskite oxide LaAlO3 using molecular beam epitaxy. The structural properties are investigated using reflection-high-energy electron diffraction, x-ray diffraction, and cross-section transmission electron microscopy, which reveal relaxed epitaxial island growth. Photoelectron spectroscopy measurements verify the Zintl-Klemm nature of the bonding in the material and are utilized to determine the band offset and the work function of SrAl4, while transport measurements confirm its metallic behavior. The experimentally observed properties are confirmed using density functional calculations.Copyright (2013) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. along with the following message: The following article appeared in (Physical Review B, 88 (4)) and may be found at (http://journals.aps.org/prb/abstract/10.1103/PhysRevB.88.045314)
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank
No full textThe dataset contains results of a genome-wide association studies for age-related hearing impairment (ARHI)-related traits as described in the following publication: Wells, H.R.R., Abidin, F.N.Z., Freidin, M.B. et al. Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. Sci Rep 11, 6470 (2021). https://doi.org/10.1038/s41598-021-85871-6 {"references": ["Wells, H.R.R., Abidin, F.N.Z., Freidin, M.B. et al. Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. Sci Rep 11, 6470 (2021). https://doi.org/10.1038/s41598-021-85871-6"]
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank
No full textThe dataset contains results of a genome-wide association studies for age-related hearing impairment (ARHI)-related traits as described in the following publication:
Wells, H.R.R., Abidin, F.N.Z., Freidin, M.B. et al. Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. Sci Rep 11, 6470 (2021). https://doi.org/10.1038/s41598-021-85871-
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