469 research outputs found
Medical Terminology : A Short Course / by Davi-Ellen Chabner
No full textPrevious edition: St. Louis, Mo.: Elsevier Saunders, 2012Includes indexxvii, 415 pages :Quickly master the basics of medical terminology and begin speaking and writing terms almost immediately! Using Davi-Ellen Chabner's proven learning method, Medical Terminology: A Short Course, 7th Edition omits time-consuming, nonessential information and helps you build a working medical vocabulary of the most frequently encountered prefixes, suffixes, and word roots. Medical terms are introduced in the context of human anatomy and physiology to help you understand exactly what they mean, and case studies, vignettes, and activities demonstrate how they're used in practice. With all this plus medical animations, word games, and flash cards on the Evolve companion website, you'll be amazed at how easily medical terminology becomes part of your vocabulary
Bitcoin e cyber self-laundering: lo sguardo sospettoso della Cassazione sull'impiego di criptovaluta
No full textIn Judgment n. 27023 of 2022, the italian Supreme Court recognized the confgurability of the crime of self-money laundering in the conduct of a person who uses the proceeds of crimes committed by him to purchase bitcoin, not directly, but through the intermediation of cryptocurrency exchange companies.
The Author takes the pronouncement as a starting point to probe the extent to which the culture of suspicion, with which the anti-money laundering legislation is imbued, and the stigmatization of cryptocurrency have influenced the Supreme Court's guidance, in which there emerges a strong temptation to establish a kind of automatism between the input of illicit proceeds into the bitcoin system and the integration of the crimes of money laundering or self-money laundering. The Author sets out to examine whether conduct in the use of cryptocurrencies can actually be sanctioned without resorting to hermeneutic forcing of the incriminating norms
Il lavoro di pubblica utilità come sanzione sostitutiva delle pene detentive brevi
No full textThe Cartabia Reform has attempted to relaunch alternative sanctions and to accentuate their re-educational purpose, in particular by including public service work among them, on the Anglo-Saxon ‘Community Service’ model. The author analyses the innovations introduced by the reform, their practical effects and critical issues and reflects on the problematic nature of the subject of re-education
Compliance, riparazione e diversione. Prime sperimentazioni italiane dei pre-trial agreements nel campo della responsabilità da reato delle imprese
No full textThe Author notes how, in the practice of some judicial offices, forms of corporate trial diversion have begun to develop that show clear analogies with the U.S. pre-trial agreements model, as a spontaneous evolution of the criminal compliance paradigm. Thus, while Italian doctrine debates whether such in- struments of diversion should be imported, formal or informal agreements that use non-punishment as a bargaining chip are now an undeniable reality of the corporate liability system
Il fallimento dell’impresa mafiosa: tra tutela dell’interesse pubblico e par condicio creditorum
No full textThe author examines the main problems connected with the interference between patrimonial prevention measures and bankruptcy proceeding, also in the light of the recent introduction of the Code for company crises and insolvency, and questions the adequacy of the protection recognized by the Anti-Mafia Code for bona fide creditors of the mafia company
Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia
No full textThe formation of B-cell receptor immunoglobulin (BcR IG) is the result of a multi-step process that starts at the pro-B cell stage with the VDJ gene recombination of IG genes of the heavy chain, followed by VJ recombination of the light chain genes at the pre-B II cell stage. As a result, a fully functional BcR IG is expressed on the surface of any given naive B cell. After antigen encounter, somatic hypermutation (SHM) and class-switch recombination (CSR) act on the rearranged IG genes within the context of affinity maturation, leading to the expression of a BcR IG with unique immunogenetic and functional characteristics. Since B-cell neoplasms arise from the transformation of a single B cell, this renders IG gene rearrangements ideal clonal markers as they will be identical in all neoplastic cells of each individual clone. Furthermore, the rearranged IG sequence can also serve as a cell development/maturation marker, given that its configuration is tightly linked to specific B-cell developmental stages. Finally, in certain instances, as in the case of chronic lymphocytic leukemia (CLL), the clonotypic IG sequence and, more specifically, the load of somatic hypermutations within the rearranged IG heavy variable (IGHV) gene, holds prognostic and potentially predictive value. However, in order to take full advantage of the information provided from the analysis of the clonotypic IG gene rearrangement sequences, robust methods and tools need to be applied. Here, we provide details regarding the methodologies necessary to ensure reliable IG sequence analysis based on the recognized expertise of the European Research initiative on CLL (ERIC). All methodological and analytical steps are described below, starting from the isolation of blood mononuclear cells (PBMC), moving to the identification of the clonotypic IG rearrangement and ending with the accurate interpretation of the SHM status
The microenvironment in lymphomas - Dissecting the complex crosstalk between tumor cells and 'by-stander' cells
No full textIn lymphomas, it is increasingly apparent that the microenvironment is an essential player not only for lymphoma pathogenesis but also for disease progression and therapy resistance. In recent years, we have begun to understand the complex crosstalk between the neoplastic cells and other immune cells, such as T and NK cells, and stromal cells, as well as the signaling pathways that become aberrantly activated through this dialogue (e.g. B-cell receptor, Toll-like receptor and NF-kappa B signaling). In this series of reviews, the intricate interplay between lymphoma cells and 'by-stander' cells will be illustrated in representative lymphoma entities, namely Hodgkin lymphomas, follicular lymphomas, marginal-zone lymphomas, chronic lymphocytic leukemia, and T-cell lymphomas, where the crucial role played by the microenvironment has become particularly evident. Furthermore, important clues to the pathobiology of lymphomas have emerged from (i) the recognition of pre-malignant conditions, such as monoclonal B-cell lymphocytosis or in situ lymphomas, (ii) the identification of microbial and/or auto-antigens that are linked to particular entities, as well as (iii) the established increased risk of lymphomas in certain autoimmune/inflammatory conditions, all critical aspects that will be further elaborated in this thematic issue. Our increasing knowledge of these interactions and associations has finally allowed us to design targeted or immune-mediated strategies to interfere with the lymphoma microenvironment, thereby opening promising therapeutic avenues on the road to cure for these yet incurable diseases.</p
Disability as both a Source of Marginalization and a Tool for Agency In the Work of William Shakespeare
No full textThis program is presented in conjunction with the exhibition “’And there’s the humor of it!’ Shakespeare and the Four Humors,” created by the National Library of Medicine and on display at McGoogan Library (Level 6) through March 15. An online exhibition is also available.
Historically disability is ignored or absent in literature, art, culture, and media. While limited, representation of disability has been critiqued for perpetuating both inaccurate and demeaning stereotypes, leading to prejudice and discrimination against the disability community. William Shakespeare’s works often reflect the complex attitudes toward disability present in early Modern England. While not explicitly defined by Shakespeare, his works explore disability through a variety of characters and themes, reflecting both the prejudices and attitudes toward disabled people during this time.
During this program, Davi Kallman, PhD will review the two most prominent and modern models of disability (medical and social models) and will discuss how Shakespeare’s work has influenced the creation of both these widely accepted models.
Additionally, she will discuss how Shakespeare’s plays contain references to disabilities and non-normative bodies. This includes a review of these common themes addressed by disability and media scholars in William Shakespeare’s work: Disability as a Marker of Character Empathy and Humanity of Disability Social Stigma and Marginalization of Disability Disability as a Source of Power or Agency
Lastly, she will reflect on how Shakespeare’s treatment of disability is multifaceted, blending prejudices of his era with moments of insight and empathy toward the disabled community. While his works do not advocate for progressive understanding of disability by modern standards, they offer nuanced portrayals that ask us to reflect on our own understanding of the social and personal implications of non-normative minds and bodies.
About Dr. Davi Kallman
Davi Kallman, PhD is a Mexican, Jewish, Disabled Woman whose intersecting identities amplify her advocacy for traditionally marginalized communities. She is a published author, an award-winning speaker, and a powerful institutional change-maker.
Dr. Davi Kallman is the District Dean of Student Engagement at Pierce College in Lakewood Washington. Kallman also serves as Pierce College’s 504/ADA Coordinator. In this role she works with Pierce College District students, faculty, and staff to ensure that student disability rights are upheld. In her spare time, she serves as an adjunct Professor of Communication at Tacoma Community College (TCC).
She earned her PhD in Health Communication from the Edward R. Murrow College of Communication at Washington State University, following her master’s and bachelor’s degrees in communication from the University of Texas at El Paso (UTEP). Dr. Kallman leverages her expertise in media literacy and other interventions to dismantle stereotypes in institutional settings, fostering environments that are more inclusive and equitable.
A key part of her journey has been informed by her own experiences as a dyslexic individual. Her work reflects her commitment to ensuring that individuals with disabilities—both visible and “hidden”—receive the support they need to thrive. Dr. Kallman’s experiences inform her vision for a more inclusive and accessible higher education system.https://digitalcommons.unmc.edu/mcgoogan_lectures/1012/thumbnail.jp
High occurence of DRB1 11 in chronic lymphocytic leukaemia families
No full textRecently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development
Reconstructed drought variability across Mongolia based on tree-ring records:
No full textOur understanding of climate in Mongolia is hindered by the extremely limited meteorological data in the region. Longer records, and insight into temporal drought patterns could aid greatly in anticipating extreme events and agrarian planning. Tree-ring reconstructions can provide longer, high-resolution records of climate variability in regions where recorded data are limited.
In central Mongolia, streamflow for the Selenge River (1637-1997), the largest river in Mongolia, was reconstructed. Regression models resulted in a reconstruction of streamflow that explains 49 percent of the flow variation. The wettest 5-year period was 1764-1768 and the driest period was 1854-1858. The most extended wet period is 1794-1802 and an extended dry period is 1778-1783. Spectral analysis, a method for identifying periodicities within a time series, indicated significant variation in the frequencies common to Pacific Ocean variations (PDO and ENSO) and also some quasi-solar and lunar-nodal periodicities.
In the far west, a grid cell of the Palmer Drought Severity Index (PDSI) was reconstructed (1565-2003) and explains 41 percent of the total variance in the instrumental PDSI. The reconstruction shows that starting in the 20th Century and continuing into the 21st Century there was a large-scale regional increase in growing-season moisture conditions compared to the prior centuries, a trend not seen in central or eastern Mongolian tree-ring reconstructions. Spectral analysis shows significant periodicities at approximately 22 (99% significance level), 11 (90%), 7 (99%), and 5 (99%) years.
Also presented is a summer drought reconstruction for all of Mongolia, based on a network of 34 tree-ring chronologies that span the country. The PDSI model explains 61% of the variance over the most replicated period (1703-1993) and nested model methods were used to create the longest reconstruction possible (1520-1993). The reconstruction shows that droughts from 1999-2002, felt across central and eastern Mongolia, were extreme compared to the past 500 years. Significant periodicities are found at 40 (90%), 19.3 -25 (99%), 11.6 (95%), 6.4-7.2 (95%), and 2.8 years (99%).
These high-resolution drought reconstructions supplement and extend the sparse meteorological data in Mongolia and allow for a long-term perspective of drought across Mongolia. As temperatures continue to rise in Mongolia, and much of the Northern hemisphere, drought may be an increasingly dire issue for human and environmental well being. Future predictions of drought and forecast capabilities are summarized, as are current climate risk management program.Ph.D.Includes bibliographical referencesby Nicole K. Dav
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