623 research outputs found
Correction to: Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap
No full textThe article “Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap”, written by Raffaella Coppier, Elisabetta Michetti and Luisa Scaccia, was originally published electronically on the publisher’s internet portal on 05 July 2023 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 24 February 2024 to © The Author(s) 2024 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors
No full textIn the last years, the explosion of high throughput sequencing technologies has enabled epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal squamous cell carcinoma (OPSCC) epigenetic landscape. In this setting, the cellular pathways contributing to the neoplastic phenotype, including cell cycle regulation, cell signaling, DNA repair, and apoptosis have been demonstrated to be potential targets of epigenetic alterations in OPSCC. Of note, it has becoming increasingly clear that HPV infection and OPSCC lifestyle risk factors differently drive the epigenetic machinery in cancer cells. Epigenetic changes, including DNA methylation, histone modifications, and non-coding RNA expression, can be used as powerful and reliable tools for early diagnosis of OPSCC patients and improve prognostication. Since epigenetic changes are dynamic and reversible, epigenetic enzymes may also represent suitable targets for the development of more effective OPSCC therapeutic strategies. Thus, this review will focus on the main known epigenetic modifications that can occur in OPSCC and their exploitation as potential biomarkers and therapeutic targets. Furthermore, we will address epigenetic alterations to OPSCC risk factors, with a particular focus on HPV infection, tobacco exposure, and heavy alcohol consumption
Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors
No full textPhospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase family. Originally, it was identified as a membrane protein involved in maintaining plasma membrane asymmetry. However, studies conducted over the past few years have shown the involvement of PLSCR1 in several other cellular pathways. Indeed, PLSCR1 is not only embedded in the plasma membrane but is also expressed in several intracellular compartments where it interacts with a diverse repertoire of effectors, mediators, and regulators contributing to distinct cellular processes. Although most PLSCR1 interactors are thought to be cell-type specific, PLSCR1 often exerts its regulatory functions through shared mechanisms, including the trafficking of different molecules within intracellular vesicles such as endosomes, liposomes, and phagosomes. Intriguingly, besides endogenous proteins, PLSCR1 was also reported to interact with exogenous viral proteins, thereby regulating viral uptake and spread. This review aims to summarize the current knowledge about the multiple roles of PLSCR1 in distinct cellular pathways. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00895-3
Elisabetta I come Cinzia: Una regina e il suo oceano
No full textThe defeat of the Spanish Armada in the Channel in 1588 turned ‘a weak and feeble woman’ into one of the most relevant characters of late 16th-century European history: Elizabeth I, the Tudor Queen, was considered a semi-divine creature whom the myth, by comparing her to Moon goddesses like Diana and Cinthia, had made known as Semper Eadem.
The identification of the queen with Cinthia became more and more evident after the events occurred in 1588, when she was hailed as the moon goddess par excellence in a series of texts written by her contemporaries. It was in that period, the last decades of the 16th century, that Sir Walter Ralegh, courtier, poet and seaman, wrote The Poems to Cynthia: a collection of short poems where Elizabeth I, the lady of the seas, is addressed as his beloved. The role of Elizabeth as Cinthia is evident above all in Ralegh’s Last Book of the Ocean to Cynthia, an unfinished poem where the author, desperate for being in disgrace, appeals to her clemency and addresses her as the empress of the ocean.La sconfitta della flotta spagnola nelle acque della Manica nel 1588 trasformò una donna sola e fragile in una delle figure più rilevanti della storia europea di fine XVI secolo: Elisabetta I Tudor divenne per i suoi sudditi una creatura semidivina che il mito, accostandola alle divinità lunari Diana e Cinzia, avrebbe consegnato alla Storia come Semper Eadem.
Pur essendo evidente già nei primi tempi del suo regno, l’identificazione della sovrana con Cinzia, la dea che governa i mari e i corsi d’acqua, si fa ancora più evidente dopo il 1588, quando si assiste ad una fioritura di testi che esaltano Elisabetta I come la dea lunare per eccellenza.
Sempre in quegli anni di fine XVI secolo, Sir Walter Ralegh compone The Poems to Cynthia: letterato, cortigiano e uomo di mare, Ralegh dedicherà il suo amore ad Elisabetta come Cinzia, signora dei mari. Il legame tra Elisabetta e l’oceano è soprattutto evidente in Last Book of the Ocean to Cynthia, un poemetto incompiuto in cui il poeta, caduto in disgrazia, riunisce sotto il nome di Cinzia, la donna e la regina, l’amante e la dea, trasformando così Elisabetta in dea e imperatrice dei mari
Elisabetta I come Cinzia. Una regina e il suo oceano.
No full textLa sconfitta della flotta spagnola nelle acque della Manica nel 1588 trasformò una donna sola e fragile in una delle figure più rilevanti della storia europea di fine XVI secolo: Elisabetta I Tudor divenne per i suoi sudditi una creatura semidivina che il mito, accostandola alle divinità lunari Diana e Cinzia, avrebbe consegnato alla Storia come Semper Eadem. Pur essendo evidente già nei primi tempi del suo regno, l’identificazione della sovrana con Cinzia, la dea che governa i mari e i corsi d’acqua, si fa ancora più evidente dopo il 1588, quando si assiste ad una fioritura di testi che esaltano Elisabetta I come la dea lunare per eccellenza. Sempre in quegli anni di fine XVI secolo, Sir Walter Raleigh compone ‘The Poems to Cynthia’: letterato, cortigiano e uomo di mare, Raleigh dedicherà il suo amore ad Elisabetta come Cinzia, signora dei mari. Il legame tra Elisabetta e l’oceano è soprattutto evidente in ‘Last Book of the Ocean to Cynthia’, un poemetto incompiuto in cui il poeta, caduto in disgrazia, riunisce sotto il nome di Cinzia, la donna e la regina, l’amante e la dea, trasformando così Elisabetta in dea e imperatrice dei mari.The defeat of the Spanish Armada in the Channel in 1588 turned ‘a weak and feeble woman’ into one of the most relevant characters of late 16th-century European history: Elizabeth I, the Tudor Queen, was considered a semi-divine creature whom the myth, by comparing her to Moon goddesses like Diana and Cinthia, had made known as Semper Eadem. The identification of the queen with Cinthia became more and more evident after the events occurred in 1588, when she was hailed as the moon goddess par excellence in a series of texts written by her contemporaries. It was in that period, the last decades of the 16th century, that Sir Walter Raleigh, courtier, poet and seaman, wrote ‘The Poems to Cynthia’: a collection of short poems where Elizabeth I, the lady of the seas, is addressed as his beloved. The role of Elizabeth as Cinthia is evident above all in Raleigh’s ‘Last Book of the Ocean to Cynthia’, an unfinished poem where the author, desperate for being in disgrace, appeals to her clemency and addresses her as the empress of the ocean
Praxiphanes of Mytilene (called 'of Rhodes'). The Sources, Text and Translation
No full textNuova edizione dei frammenti di Prassifane di MItilene, detto di Rodi, con traduzione e note. Prassifane era uno dei filosofi di età ellenistica implicato in ruoli anche pubblici in merito ai quali abbiamo segnali di onori ricevuti (cittadinanza e prossenia). I frammenti superstiti permettono di ricostruire la personalità di un filosofo peripatetico, allievo di Teofrasto, che pur avendo acquisito fama come 'primo grammatico' ed essersi occupato di critica letteraria, di poeti, di poetica e di 'storia', non lasciò da parte interessi di etica e probabilmente di fisica. Importante la sua attività a Rodi, nel pieno III sec. a.C., in un periodo nel quale l'isola rivestì un ruolo particolarmente rilevante dal punto di vista politico, economico e culturale per il mondo ellenico.New Critical Edition of the sources related to Praxiphanes of Mytilene, called of Rhodes' (3rd BC), a Peripatetic philosopher, pupil of Theophrastus, whose entire works are lost. The new collection of fragments shows that he was a philosopher involved in public life, called 'first grammarian' and author of works on literary critics, on poetics, on poets, on history, on ethics and physics. He lived and worked in Rhodes in a special period when this island was an important economic, political and cultural centre of the Hellenic world
Utopia e realtà: Ercole II principe mercantilista
No full textIl saggio disegna sinteticamente la politica economica praticata da Ercole II a metà del Cinquecento, che sostenne il commercio invitando mercanti forestieri, ma che si occupò anche delle attività produttive impiantando una produzione laniera. Infine, si analizzano gli effetti delle scelte ducali valendosi dei dati fiscali tratti dai registri della Mercanzia, soffermandosi anche sulla fiera di Rovig
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