1,721,042 research outputs found
Gallstone pancreatitis and laparoscopic cholecystectomy
No full textLaparoscopic cholecystectomy is now considered the gold-standard for the treatment of gallbladder stones (NH Consensus Conference 1992). Moreover, its feasibility in complex problems like acute cholecystitis, common bile duct stones and biliary pancreatitis is more widely recognized. The aim of this paper is to evaluate the efficacy of the laparoscopic treatment in acute biliary pancreatitis comparing it with the traditional open surgery. Since February 1991 to January 1995 we treated 18 patients submitted with a diagnosis of acute biliary pancreatitis. In 15 patients the pancreatitis was interstitial while 3 had necrotic pancreatitis. All patients, except 2, were submitted to a laparoscopic cholecystectomy during the same admission, with a mean interval of 11 days from the day of admission to surgery. The other 2 cases, who suffered a severe necrotic pancreatitis, were operated after 3 months. Endoscopic retrograde-cholangiopancreatography (ERCP) was performed in 8 cases (38.8%), with 7 papillosphincterotomy (PST) and stone extraction. In only one case it was necessary to convert to open surgery. The mean operation time was 55 minutes. One patient died due to cardiorespiratory failure 16 days after surgery (death rate: 5.5%). Complications were not observed in the other patients. Our results are similar to those observed in the literature showing that the majority of the patients with biliary pancreatitis can be submitted to laparoscopic surgery with advantage. In case of common bile duct stones, we prefer to perform an ERCP with PST if necessary. We did not observe complications with this strategy but it is probably that in the future the laparoscopic approach will be applied for both gallbladder and CBD stones. At the moment this is reserved to the more experienced surgeons and specialized centers
Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome
No full textWe have isolated a novel human zinc finger gene, ZNF41, from a human X-chromosome-specific library. Nucleotide sequence analysis reveals that ZNF41 potentially encodes a polypeptide featuring an array of 18 contiguous zinc fingers of the C2H2 type. Multiple polyadenylated transcripts homologous to ZNF41 are present at different levels in several distinct cell types. Southern analyses of somatic cell hybrids containing either intact or rearranged X chromosomes confirm the genomic origin of the isolated gene and establish that it is localized between Xcen and Xp22.1
Malignant enterochromaffinlike cell carcinoid of the gastric stump: an ultrastructural study
No full text
Ageing as a Trait de Union between diabetes and dementia for frailty
No full textA frail patient is one who carries a sum of poly-pathologies, whose co-existence may shorten his life expectation. Diabetes mellitus type 2 and metabolic syndrome play a substantial role in it, but dementia has increasingly risen in importance. Interestingly, the insulin pathway was suggested to be responsible for the metabolic cascade that leads to amyloid-beta deposit and pathology. Nevertheless, a clear relationship between them was just experimentally, rather than clinically demonstrated. In this work the authors suggest a possible link between insulin, diabetes and Alzheimer's disease, whose co-existence could be responsible for physical and cognitive decline but not for frailty. We suggest that these factors could be responsible for frailty only if senescence-associated
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Statistical evaluation of the coding capacity of complementary DNA strands
No full textTwo independent methods are used to evaluate the protein-coding information content in different classes of DNA sequences.The first method allows to evaluate the statistical relevance of finding unidentified reading frames, longer than 100 codons, on both DNA strands of: a) 117 DNA sequences that code for 142 nuclear proteins; b) 39 stable RNA coding sequences and c) 36 other DNA sequences which include regulatory and as yet unknown function sequences. The finding of 50 reading frames longer than 100 codons (complementary inverted proteins or c.i.p. genes) located on the DNA strand complementary to the protein-coding one is drastically in excess of the number predicted by chance alone.An independent method (testcode) applied to c.i.p. gene sequences, which assigns the probability of coding to a given sequence, predicts that more than 50% of these genes are translated in a functional product.These analyses indicate the existence of a new class of protein-coding genes, located on the DNA sequences complementary to the protein-coding DNA strand. © 1984 IRL Press Limited
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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