120 research outputs found
Vespasiano fra legittimità del potere e "arcana imperii"
No full textVespasiano dovette affrontare il problema della legittimità della successione alla dinastia giulio-claudia, come conferma la lex de potestate Vespasiani. Ma anch'egli si arrese di fronte alla necessità di garantire una continuità ricorrendo ad una successione dinastic
Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO)
No full textThe incidence of Cholangiocellular carcinoma (CCA) is increasing, due to a sharp increase of the intrahepatic form. Evidence-ascertained risk factors for CCA are primary sclerosing cholangitis, Opistorchis viverrini infection, Caroli disease, congenital choledocal cist, Vater ampulla adenoma, bile duct adenoma and intra-hepatic lithiasis. Obesity, diabetes, smoking, abnormal biliary-pancreatic junction, bilio-enteric surgery, and viral cirrhosis are emerging risk factors, but their role still needs to be validated. Patients with primary sclerosing cholangitis should undergo surveillance, even though a survival benefit has not been clearly demonstrated. CCA is most often diagnosed in an advanced stage, when therapeutic options are limited to palliation. Diagnosis of the tumor is often difficult and multiple imaging techniques should be used, particularly for staging. Surgery is the standard of care for resectable CCA, whilst liver transplantation should be considered only in experimental settings. Metal stenting is the standard of care in inoperable patients with an expected survival >4 months. Gemcitabine or platinum analogues are recommended in advanced CCA whilst there are no validated neo-adjuvant treatments or second-line chemotherapies. Even though promising results have been obtained in CCA with radiotherapy, further randomized controlled trials are needed. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved
03 - MRI-based radiomics in carbon-ion therapy of skull-base chordomas: Preliminary results for predicting local control
No full textCarbon ion radiotherapy and completion pancreatectomy. A feasible model to explore a new integrated approach?
No full textEvaluation of residual abdominal tumour motion in carbon ion gated treatments through respiratory motion modelling
No full textAt the Italian National Centre for Oncologic Hadrontherapy (CNAO) patients with upper-abdominal tumours are being treated with carbon ion therapy, adopting the respiratory gating technique in combination with layered rescanning and abdominal compression to mitigate organ motion. Since online imaging of the irradiated volume is not feasible, this study proposes a modelling approach for the estimation of residual motion of the target within the gating window. The model extracts a priori respiratory motion information from the planning 4DCT using deformable image registration (DIR), then combines such information with the external surrogate signal recorded during dose delivery. This provides estimation of a CT volume corresponding to any given respiratory phase measured during treatment. The method was applied for the retrospective estimation of tumour residual motion during irradiation, considering 16 patients treated at CNAO with the respiratory gating protocol. The estimated tumour displacement, calculated with respect to the reference end-exhale position, was always limited (average displacement is 0.32 ± 0.65 mm over all patients) and below the maximum motion defined in the treatment plan. This supports the hypothesis of target position reproducibility, which is the crucial assumption in the gating approach. We also demonstrated the use of the model as a simulation tool to establish a patient-specific relationship between residual motion and the width of the gating window. In conclusion, the implemented method yields an estimation of the repeatability of the internal anatomy configuration during gated treatments, which can be used for further studies concerning the dosimetric impact of the estimated residual organ motion
22q11.2 Microduplication syndrome and epilepsy with continuous spikes and waves during sleep (CSWS). A case report and review of the literature.
No full textChromosome 22q11.2 microduplication syndrome is characterized by a variable and usually mild phenotype and by incomplete penetrance. Neurological features of the syndrome may entail intellectual or learning disability, motor delay, and other neurodevelopmental disorders. However, seizures or abnormal EEG are reported in a few cases. We describe a 6-year-old girl with microduplication of chromosome 22q11.2 and epilepsy with continuous spikes and waves during sleep (CSWS). Her behavioral disorder, characterized by hyperactivity, impulsiveness, attention deficit, and aggressiveness, became progressively evident a few months after epilepsy onset, suggesting a link with the interictal epileptic activity characterizing CSWS. We hypothesize that, at least in some cases, the neurodevelopmental deficit seen in the 22q11.2 microduplication syndrome could be the consequence of a disorder of cerebral electrogenesis, suggesting the need for an EEG recording in affected individuals. Moreover, an array-CGH analysis should be performed in all individuals with cryptogenic epilepsy and CSWS
A cohesive-zone model for steel beams strengthened with pre-stressed laminates
No full textAbstractWe analyse the problem of a simply supported steel beam subjected to uniformly distributed load, strengthened with a pre-stressed fibre-reinforced polymer (FRP) laminate. According to the assumed application technology, the laminate is first put into tension, then bonded to the beam lower surface, and finally fixed at both its ends by suitable connections. The beam and laminate are modelled according to classical beam theory. The adhesive is modelled as a cohesive interface with a piecewise linear constitutive law defined over three intervals (elastic response, softening response, debonding). The model is described by a set of differential equations with suitable boundary conditions. An analytical solution to the problem is determined, including explicit expressions for the internal forces and interfacial stresses. For illustration, an IPE 600 steel beam strengthened with a Sika® Carbodur® FRP laminate is considered. First, the elastic limit state load of the unstrengthened beam is determined. Then, the loads corresponding to the elastic limit states in the steel beam, adhesive, and laminate for the strengthened beam are calculated. As a result, the increased elastic limit state load of the strengthened beam is obtained
Indagine sierologica nei confronti di agenti di malattia respiratoria in allevamenti bovini ubicati in Sicilia
No full textOrgan motion quantification and margins evaluation in carbon ion therapy of abdominal lesions
No full textIn image-guided particle radiotherapy of abdominal lesions, respiratory motion hinders treatment accuracy. In this study, 2D cineMRI data were used to quantify the tumor (GTV) motion and to evaluate the clinical approach based on deriving an internal target volume (ITV) from a planning 4DCT for gating treatments
- …
