12 research outputs found
Brief communication: Hydrological and hydraulic investigation of the extreme September 2024 flood on the Lamone River in Emilia-Romagna, Italy
No full textIn September 2024, several European countries
experienced extreme and prolonged record-breaking rainfall
that induced severe flooding and caused widespread damage,
casualties, and disruptions. In this context, the Emilia-
Romagna region in northern Italy suffered heavy precipitation
primarily affecting the Lamone River basin, where a
levee breach occurred near the village of Traversara, causing
the flooding of urban settlements, vineyards, orchards,
and crops. Since the same area was severely impacted by
devastating floods no later than May 2023, it is relevant to
understand whether this area indeed faced extreme precipitation
events in 2 consecutive years and to explore how the
hydrological–hydraulic modelling can support the preparedness
against these recurring events
Indagine numerico-sperimentale finalizzata alla caratterizzazione del bacino imbrifero sotterraneo del Lago di Monate (VA)
No full textLo scopo del seguente lavoro di Tesi è quello di approfondire il tema del bilancio idrologico del bacino del Lago di Monate servendosi di modellazioni idrologiche che tengano conto della variabilità dell’estensione del bacino imbrifero sotterraneo del lago. Nella fase introduttiva dell’elaborato vengono riportate la descrizione dell’area di studio e del bacino idrologico del lago, le attività di monitoraggio in corso e il modello idrologico utilizzato per l’analisi. Sono stati introdotti quattro schemi concettuali di applicazione del modello idrologico, tramite l’implementazione del programma di calcolo R: il primo è identificato dal classico modello di trasformazione afflussi-deflussi HyMOD che prevede l’utilizzo di 5 parametri; il secondo e terzo schema concettuale impongo la variabilità dell’area del bacino sotterraneo strettamente correlata all’andamento delle precipitazioni, imponendo un incremento o riduzione dell’area rispettivamente all’aumentare o al diminuire delle precipitazioni; infine nel quarto schema l’area del bacino sotterraneo è stimata dal modello HyMOD come sesto parametro. Ognuno dei precedenti schemi è stato valutato secondo diverse strategie di calibrazione, dalle quali è stato possibile ottenere i set di parametri con i quali eseguire le simulazioni del modello. Analizzando i risultati si nota come tutti i modelli proposti restituiscano performance molto elevate negli anni caratterizzati da elevata umidità, mentre evidenziano un calo di prestazioni negli anni “anomali” contraddistinti da un comportamento siccitoso. Si deduce dunque che, al netto di altri possibili dati inaffidabili, il modello presenta diversi limiti che saranno oggetto di analisi future
Expression of the mRNA stability regulator Tristetraprolin is required for lactation maintenance in the mouse mammary gland
No full textTristetraprolin (TTP), an mRNA-binding protein that negatively controls levels of inflammatory factors, is highly expressed in the lactating mouse mammary gland. To determine the biological relevance of this expression profile, we developed bi-transgenic mice in which this protein is specifically down-regulated in the secretory mammary epithelium in the secretory mammary epithelium during lactation. Our data show that TTP conditional KO mice produced underweight litters, possibly due to massive mammary cell death induced during lactation without the requirement of additional stimuli. This effect was linked to overexpression of inflammatory cytokines, activation of STAT3 and down-regulation of AKT phosphorylation. Importantly, blocking TNFa activity in the lactating conditional TTP KO mice inhibited cell death and similar effects were observed when this treatment was applied to wild-type animals during 48 h after weaning. Therefore, our results demonstrate that during lactation TTP wards off early involution by preventing the increase of local inflammatory factors. In addition, our data reveal the relevance of locally secreted TNFa for triggering programmed cell death after weaning.Fil: Goddio, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Gattelli, Albana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Tocci, Johanna Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Perez Cuervo, Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Stedile, Micaela Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Stumpo, Deborah. National Institute Of Environmental Health Science; Estados UnidosFil: Hynes, Nancy. Friedrich Miescher Institute For Biomedical Research; SuizaFil: Blackshear, Perry. National Institute Of Environmental Health Science; Estados UnidosFil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Kordon, Edith Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentin
Regulation of the maternal-to-embryonic transition in "C. elegans"
No full textReproduction is a fundamental process of life which allows the survival of each
species through the birth of young species members. Several modes of
reproduction evolved and are classified into sexual and asexual reproduction.
Sexual reproduction involves the fusion of two gametes: the female oocyte and
the male sperm. Parthenogenesis is a form of asexual reproduction in which
oocytes alone develop into viable progeny. Parthenogenesis most likely
independently evolved multiple times from sexual reproduction and has been
described in various invertebrate and vertebrate species.
In certain phyla, like in nematodes, closely related species differ in their modes of
reproduction. Studying reproduction and early embryogenesis in these species
allows the identification of molecular mechanisms which permit or restrict
parthenogenesis. From other model organisms, several regulatory candidates
are known. For example in flies, sperm independent oocyte activation and
spindle formation facilitate parthenogenetic development, whereas in mammals,
genetic imprinting, sperm dependent oocyte activation and oocytic centriole
elimination restrict parthenogenesis.
We study the sexually reproducing nematode C. elegans in which
parthenogenetic development has not been described. We analyzed the
influence of maternally inherited epigenetic modifiers and found that modifiers
involved in maintaining the soma - germ line distinction have no additional role in
regulating the onset of embryonic transcription. We further analyzed embryonic
features in two different maternal mutant backgrounds. We found that formation
of a maternal germ line tumor, the teratoma, has striking similarities with early
embryogenesis. In contrast, ovulated but unfertilized oocytes of a feminized
mutant show early embryonic-like features but are unable to differentiate. The
ability to differentiate is most likely not due to sperm inherited components but
partially depends on the sperm triggered formation of a functional eggshell.
We conclude that in C. elegans, the onset of the maternal-to-embryonic transition
is uncoupled from sperm dependent oocyte activation which might facilitate
parthenogenesis in nematodes. Further, next to sperm dependent oocyte
activation and centriole inheritance, sperm licensed eggshell formation might
restrict parthenogenetic development in C. elegans
The Lantern, 2011-2012
No full text• Frangipani • A Shadow • Dear Anne, In this Place, Stringbean Girls • Back to a Dandelion • How to Plant a Room • Swimming Pool Poem 30 • The Naming of Daughters • Berman Museum Photographs • Truth or Dare • The Song of Remembrance, L\u27vov, Poland, 1940 • Headlights • Prayer of Thanks • Numbers Game • Pediment • Home Sick • Lust • Sand Lining Instructions • A-A-Ask a Question • Flash Cards • Columbus Day • Mr. Yoest Gives His Report to the Police Officers on Wednesday Night • Gender Trouble • The Internet Connection at Ursinus College • Assuming You\u27ll Still be Here • 10/28/11, Third Poem • October • Actions that Affirm and Confirm Us as a Community • Why I Hate The Lantern • Confessions of an Ex-Vegetarian • Run • Lunch at Caltort • Schemers • You Will Make Beautiful Babies in America • The Black Dirt Region • Il Travatore • Ghost Story • Blue Eyes and Sunny Skies • A Little Sincerity • The Bookstore • The Opposite of Serendipity • The Human Doll • Evil Deeds • Francesca • Sunday Morning • Jersey Aesthetic • Jump! • Behind Reimert • Seaweed in New Zealand • Tombee de L\u27elegance • The Window • Esperando • Rainbow to the Heavens • Encased • In Springtime • A Fiesolan Monk\u27s Room • Inside a Bone • Neon Indian • Moments of Clarity • OneFeral: A Feral Self-Portrait • Cover Image: The Conquerorhttps://digitalcommons.ursinus.edu/lantern/1177/thumbnail.jp
Long-term overall survival with dual CTLA-4 and PD-L1 or PD-1 blockade and biomarker-based subgroup analyses in patients with advanced non-small-cell lung cancer: a systematic review and reconstructed individual patient data meta-analysis
No full textImmune checkpoint inhibitors targeting PD-L1 or PD-1 as monotherapy or combined with CTLA-4 inhibitors or chemotherapy (or both) are the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, it remains unclear which patients benefit from the addition of CTLA-4 inhibitors. We aimed to evaluate whether dual checkpoint blockade with CTLA-4 and PD-L1 or PD-1 inhibitors provides similar efficacy to PD-L1 or PD-1 inhibitor monotherapy, or whether these strategies produce distinct outcomes across NSCLC subpopulations.
We conducted a search of PubMed, MEDLINE, and Embase for randomised phase 3 trials published from database inception to Nov 21, 2024, that investigated PD-L1 or PD-1 inhibitors, with or without CTLA-4 inhibitors, in patients with advanced NSCLC. We focused on studies reporting Kaplan-Meier survival data at 5 years or biomarker analyses based on PD-L1, KRAS, and STK11 mutational status. Individual patient data were extracted from Kaplan-Meier curves with WebPlotDigitizer version 5 and reconstructed with the IPDfromKM method. The primary endpoint of the study was 5-year overall survival in the overall population and in subpopulations based on PD-L1 tumour proportion score (TPS), tumour histology, and mutational status (mutant vs wild-type) of KRAS and STK11. This study was registered with PROSPERO, CRD420251081707.
The initial search yielded 1026 results, and six randomised clinical trials met the eligibility criteria and were included. Among the 2881 patients eligible for analysis (838 [29·1%] female and 2043 [70·9%] male), 1282 received dual CTLA-4 and PD-L1 or PD-1 blockade and 1599 received single PD-L1 or PD-1 blockade. Patients treated with dual CTLA-4 and PD-L1 or PD-1 blockade had similar median overall survival compared with those treated with single PD-L1 or PD-1 inhibition (16·1 months [95% CI 15·0-17·8] vs 16·9 months [15·5-18·3]; HR 0·95 [95% CI 0·87-1·03], p=0·19). Median overall survival was significantly longer with dual CTLA-4 and PD-L1 or PD-1 blockade among patients with PD-L1 TPS less than 1% versus those treated with single PD-L1 or PD-1 inhibition (15·5 months [95% CI 13·6-18·5] vs 14·5 months [13·4-15·9]; HR 0·85 [95% CI 0·74-0·98], p=0·021), with 5-year overall survival rates of 16·6% (95% CI 13·4-20·6) versus 9·3% (7·0-12·3), respectively. Median overall survival in patients with tumours harbouring STK11 mutations was also significantly longer with dual CTLA-4 and PD-L1 or PD-1 blockade compared with single PD-L1 or PD-1 inhibition (13·9 months [95% CI 9·8-20·8] vs 7·8 months [6·4-12·9]; HR 0·67 [95% CI 0·49-0·91], p=0·012). However, no significant differences in overall survival were found between treatment groups by tumour histology (squamous vs non-squamous NSCLC) or by KRAS mutational status.
Compared with single PD-L1 or PD-1 inhibition, dual immune checkpoint blockade with CTLA-4 and PD-L1 or PD-1 inhibitors was associated with improved overall survival in patients with advanced NSCLC and PD-L1 TPS less than 1% and in those with STK11 mutations, but not in the overall population. Prospective validation of these results in clinical trials is warranted.
NextGenerationUE.
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NATIONAL INNOVATION SYSTEM AND MACROECONOMIC POLICIES: BRAZIL AND INDIA IN COMPARATIVE PERSPECTIVE
No full textEfforts towards economic development in Brazil and India share some common aspects. From the beginning of the 1950s to the end of the 1980s, both countries adopted import substitution policies including high tariffs and non-tariff barriers. Since the beginning of the 1990s, liberalizing economic reforms have been implemented by the respective Governments. If we compare the reach of the Brazilian reform to that of India, one could easily conclude that the former was more extensive and profound than the latter; and in conventional indicators of innovative effort such as research and development expenditures, education coverage, average years of education and literacy rate, Brazil’s results are a little bit better than those of India. However, since the beginning of the 1980s, India has been showing better general economic performance than Brazil. This paper argues and gives some empirical evidence to show that India’s performance is explained by its institutional capacity for coordinating conventional macroeconomic policies with other policies related to its National Innovation System.
A. Lepore I datori di lavoro
No full textL'inquadramento previdenziale del datore di lavoro rende edotti dei doveri contributivi del datore di lavor
The CAESAR Project for the ASI Space Weather Infrastructure
No full textThis paper presents the project Comprehensive spAce wEather Studies for the ASPIS prototype Realization (CAESAR), which aims to tackle the relevant aspects of Space Weather (SWE) science and develop a prototype of the scientific data centre for Space Weather of the Italian Space Agency (ASI) called ASPIS (ASI SPace Weather InfraStructure). To this end, CAESAR involves the majority of the SWE Italian community, bringing together 10 Italian institutions as partners, and a total of 92 researchers. The CAESAR approach encompasses the whole chain of phenomena from the Sun to Earth up to planetary environments in a multidisciplinary, comprehensive, and unprecedented way. Detailed and integrated studies are being performed on a number of well-observed “target SWE events”, which exhibit noticeable SWE characteristics from several SWE perspectives. CAESAR investigations synergistically exploit a great variety of different products (datasets, codes, models), both long-standing and novel, that will be made available in the ASPIS prototype: this will consist of a relational database (DB), an interface, and a wiki-like documentation structure. The DB will be accessed through both a Web graphical interface and the ASPIS.py module, i.e., a library of functions in Python, which will be available for download and installation. The ASPIS prototype will unify multiple SWE resources through a flexible and adaptable architecture, and will integrate currently available international SWE assets to foster scientific studies and advance forecasting capabilities
Industrial MIPyMEs of Colombia and Mexico: Factors that hinder or facilitate their development 2000-2013
No full textLa presente investigación aborda los diferentes puntos de vista teórico-prácticos de los factores productivos (trabajo, tierra, capital y tecnología) y de entorno (Política económica que a su vez se divide en Política Monetaria, Política de Rentas, Política Fiscal, Política Cambiaria y Política Exterior) que facilitan o dificultan el desarrollo económico de las MIPyMEs del sector industrial de Colombia y México en el periodo comprendido del año 2000 al 2013, tomando como referencia las teorías económicas y administrativas de Krugman (Nueva Teoría del Comercio Internacional) y Porter (Diamante de Porter), realizando un análisis con bases de datos de diversas fuentes, teniendo en cuenta que la información haya sido creada a partir de las mismas variables para ambos países, a fin de tener un resultado más objetivo para uno, en donde en primer lugar se analizaron cada uno de los factores en general, es decir se realizó una búsqueda en diversas fuentes bibliográficas y se tomó una descripción que reuniera cada uno de los componentes que cada autor planteaba; en segundo lugar se explicó la condición de estos factores para cada país a partir de las mismas variables y para finalizar en tercer lugar se recopilo a través de bases de datos del Banco Mundial, Banco Central de México, Banco de la Republica de Colombia y CEPAL además de otras fuentes y se analizó cada factor y cada variable en iguales condiciones y se logró determinar cuáles son los factores que facilitaban o dificultaban el desarrollo económico de las MIPyMEs del sector industrial.The present research deals with the different theoretical and practical points of view of productive factors (labor, land, capital and technology) and environment (Economic policy which in turn is divided into Monetary Policy, Revenue Policy, Fiscal Policy, Exchange Policy And Foreign Policy) that facilitate or hinder the economic development of MIPyMEs in the industrial sector of Colombia and Mexico in the period from 2000 to 2013, taking as a reference the economic and administrative theories of Krugman (New Theory of International Trade) and Porter (Diamond of Porter), carrying out an analysis with data bases of diverse sources, taking into account that the information has been created from the same variables for both countries, in order to have a more objective result for one, where in First, each of the factors were analyzed in general, a search was made in various bibliographic sources and a description was drawn up to gather each of the components that each author proposed; Secondly, the condition of these factors for each country was explained from the same variables, and in order to finish third, data were collected from databases of the World Bank, Central Bank of Mexico, Bank of the Republic of Colombia and CEPAL In addition to other sources and analyzed each factor and each variable under the same conditions and it was possible to determine which are the factors that facilitated or hindered the economic development of MIPyMEs in the industrial sector
