22 research outputs found
Reaction of Alkynes with Iodine Monochloride Revisited
No full text6-Exo-dig and/or 7-endo-dig iodocyclization reactions
of functionalized acetylenic derivatives with ICl are
disfavored in comparison with the corresponding electrophilic
addition reactions providing regioselectively (E)-1-
chloro-2-iodoethene derivatives. On the contrary, 6-endo-dig
and 5-exo-dig iodocyclizations of methyl ynoates with ICl
seem to be favored in comparison with the corresponding
electrophilic addition reactions
Identification of Histopathological Criteria for the Diagnosis of Canine Cutaneous Progressive Angiomatosis
No full textSIMPLE SUMMARY: In animals, cutaneous progressive angiomatosis (CPA) is a disorder with variable prognosis related to the extension and depth of infiltration of the surrounding tissues by vessels. CPA may share some microscopical features with other vascular proliferations such as low-grade well-differentiated capillaritic hemangiosarcoma (HS), making the diagnosis not always straightforward. The aim of this study is to assess the most common diagnostic microscopical features of CPA in dogs. Eleven histopathological criteria were analyzed on 31 CPA and 11 primary cutaneous HS in dogs. Features significantly associated with CPA included: lobular growth, interposition of connective tissue and adnexa between the vascular proliferation, presence of nerve fibers, and a mixed vascular proliferative component. Absence of plump/prominent endothelial cells, lack of atypia, and lack of mitoses were also significant factors for differentiating CPA from HS. In conclusion, the presence and/or absence of multiple microscopical clues allowed for the distinction of CPA from HS. ABSTRACT: The term angiomatosis is used to denote a group of well-known to poorly characterized proliferative vascular entities. In animals, cutaneous progressive angiomatosis (CPA) is a disorder with variable prognosis related to the extension and depth of infiltration of the surrounding tissues by vessels. CPA may share some microscopical features with other vascular proliferations such as low-grade well-differentiated capillaritic hemangiosarcoma (HS), making the diagnosis not always straightforward, especially in small biopsies. The aim of this study is to retrospectively assess the most common diagnostic microscopical features of CPA in dogs. In this work, 11 histopathological criteria were analyzed on 31 CPA and 11 primary cutaneous HS in dogs. Features significantly associated with CPA included: lobular growth, interposition of connective tissue and adnexa between the vascular proliferation, presence of nerve fibers, and a mixed vascular proliferative component. Absence of plump/prominent endothelial cells, lack of atypia, and lack of mitoses were also significant factors differentiating CPA from HS. Additional distinctive findings in CPA, although with no statistical association to CPA diagnosis, were vascular shunting, absence of necrosis, and endothelial cell piling up. In conclusion, the combined use of different microscopical clues allowed for the distinction of CPA from HS and was considered useful for the diagnosis of CPA
Digital signal processing techniques for personal and broadcasting satellite communication systems
No full textElectrical Engineering, Mathematics and Computer Scienc
Psychological effects of perfectionism and physical activity on gamblers.
No full textopenDal 2014 il gioco d’azzardo è inserito all’interno del Manuale Diagnostico e Statistico dei Disturbi Mentali (DSM-V) nella sottocategoria dei disturbi non correlati a sostanze e denominato come disturbo da gioco d’azzardo; si tratta del primo disturbo comportamentale inserito all’interno del Manuale. L’obiettivo del presente lavoro è di ricercare possibili predittori del gioco d’azzardo e vedere se questi possano essere messi in relazione con l’eccessiva attività fisica, comportamento che al momento non è classificato come disturbo secondo il DSM-V. In particolare, verrà mostrato, attraverso l’analisi di due articoli, come il perfezionismo possa essere considerato un predittore del disturbo da gioco d’azzardo e possa essere messo in relazione con l’eccessivo esercizio fisico. Infine, si prenderà in considerazione un articolo che analizza vari disturbi comportamentali, anche non classificati ufficialmente nel DSM-V, come l’eccesso di esercizio fisico, per vedere se quest’ultimo può essere messo in relazione con il gioco d’azzardo
ANGIOMATOSI CUTANEA PROGRESSIVA NEL CANE E NEL GATTO
No full textL’obiettivo di questa tesi è studiare retrospettivamente gli aspetti clinici, istopatologici e il follow up dell’angiomatosi cutanea progressiva (AP), rara malattia proliferativa vascolare, non-neoplastica presente nel cane e nel gatto. I casi sono stati selezionati dall’archivio di patologia del Dipartimento di Scienze Veterinarie (PI) e dell’Istituto Zooprofilattico Sperimentale delle Venezie (PD) tra il 2005 e il 2016. Sono stati inclusi diciotto casi istopatologicamente riferibili a AP, i cui dati del segnalamento e clinici correlavano con quanto riportato in letteratura. I parametri istopatologici utilizzati (margini infiltranti, il tipo di crescita lobulare e endovascolare, l’assenza di endocapillarizzazione del connettivo, l’interposizione di tessuto normale tra le proliferazioni vascolari, l’assenza di caratteri di atipia e mitosi dell’endotelio e infine la tipologia dei vasi) sono stati utili per la caratterizzazione della malattia, da soli o in combinazione, e in sette casi in cui era conosciuto il follow up, ben correlavano con l’esito benigno della proliferazione. In conclusione i parametri istopatologici individuati, sono risultati utili per la diagnosi di AP
Dopamine agonists and analogues have an antiproliferative effect on CHO-K1 cells
No full textEpidemiological studies have shown a reduced incidence of cancer in Parkinson's disease. Since nearly all parkinsonian patients with clinical impairment are treated with L-beta-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine (DA)ergic agonists, a possibility exists that these therapeutic agents can influence the risk of cancer. We studied the antiproliferative effect of these therapeutic agents (and substances structurally correlated) on Chinese hamster ovary (CHO)-K1 cell growth. Among the compounds tested, apomorphine proved to be the most potent inhibitor of CHO-K1 cell growth, with an EC(50) of 3.35 +/- 0.12 micro M. The apomorphine analogues, apocodeine and hydroxyethylnorapomorphine, were less active as inhibitors of CHO-K1 cell growth. The activity of DA, 6-hydroxydopamine (6-OHDA), phenylethylamine (PEA), L-DOPA and bromocriptine as antiproliferative was one order of magnitude lower than that of apomorphine while pergolide was ineffective. To test whether or not the oxidative potential of these compounds was important for their antiproliferative effect, several antioxidants were assayed. Among them glutathione (GSH) and dithiothreitol (DTT) were effective in reversing the anti-proliferative effect of apomorphine, DA, 6-OHDA and PEA, conversely they did not work with bromocriptine. GSH and DTT are sulphydryl-reducing agents; while their effect could explain the efficacy against apomorphine, DA and 6-OHDA, it is difficult to understand why they should have any effect on PEA as this substance does not react with sulphydryl groups. The oxidative potential as a mechanism of action was also questioned by the results obtained with dihydrorhodamine 123, a probe that changes its fluorescent emission wave when oxidized. None of the compounds, with the exception of 6-OHDA, had any effect on the fluorescent emission wave of the probe at the maximal concentrations used to inhibit CHO-K1 cell growth. At concentrations five times higher, apomorphine and DA generated reactive oxygen species but PEA and bromocriptine did not. These data demonstrate that the antiproliferative effect of these compounds is not due to their oxidative potential, but another mechanism must be postulated
Dopamine agonists and analogues have and antiproliferative effect on chinese hamster ovary cells
No full text
Reaction of Alkynes with Iodine Monochloride Revisited
No full text6-Exo-dig and/or 7-endo-dig iodocyclization reactions of functionalized acetylenic derivatives with ICl are
disfavored in comparison with the corresponding electrophilic addition reactions providing regioselectively (E)-1-chloro-2-iodoethene derivatives. On the contrary, 6-endo-dig
and 5-exo-dig iodocyclizations of methyl ynoates with ICl
seem to be favored in comparison with the corresponding
electrophilic addition reactions
Biological Restoration of Urban Soils after De-Sealing Interventions
No full textMost urban greening interventions involve soil de-sealing and management to enhance fertility. Management typically requires translocating fertile topsoil to the site, which comes at great environmental costs. We hypothesized that de-sealed urban soils would undergo an increase of their fertility without exogenous topsoil application. We assessed experimental plots with de-sealed soil with topsoil, and de-sealed soil without topsoil. Both treatments were vegetated with two ornamental shrub species and irrigated. Soil fertility was analyzed by chemical (total and organic carbon) and biological indicators of soils (biological quality index and microbial activities). Since metal contamination is related to urban de-sealed soil, we also monitored the concentration of Zn, Cu and Pb in soil and detected it in plant leaves. The results demonstrate that de-sealed urban soils rapidly restore their biological quality and fertility. Restoration of de-sealing soils can contribute to the recent growing interest reclamation of urban soils for improving the urban environment quality through the restoration of soil functions and related ecosystem services. Overall, the results of this study demonstrate that de-sealed soils can improve their functionality and can contribute to the recent growing interest in reclamation of urban soils for improving the urban environment quality
