2,138 research outputs found
Authorship in the Interstices of History, Biography, Reality and Memory: Histoire(s) du cinéma and Cabra Marcado para Morrer
No full textEste artigo contrasta Histoire(s) du cinéma de Jean-Luc Godard e Cabra Marcado Para Morrer de Eduardo Coutinho, estão engajadas com a questão da autoria no cinema. Enquanto a imagem de Godard enfatiza a capacidade que tem um filme de transmitir a visão de mundo pessoal de um artista, a presença de Coutinho na tela funciona menos como um meio de subjetivar a obra do que como um catalizador instigando cetas reações nos "atores" filmados
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
De la laïcité à la française à la théorie normative de la religion (et retour).: Un entretien de Luc Foisneau avec Cécile Laborde
No full textThis interview with Cécile Laborde was conducted by Luc Foisneau in Aubervilliers on 13th April 2023. This interview has been published on the website Politika.io in French and English versions. In addition to Critical Republicanism (Oxford 2008) and a collective volume with John Maynor, Republicanism and Political Theory (Blackwell 2008), Cécile Laborde is the author of Liberalism's Religion (Harvard 2017). She's a Fellow of the British Academy and of the Royal Academy of Belgium.Cet entretien avec Cécile Laborde a été réalisé par Luc Foisneau à Aubervilliers le 13 avril 2023. Cet entretien a été publié sur le site Politika.io en versions française et anglaise. Outre Critical Republicanism (Oxford 2008) et un volume collectif avec John Maynor, Republicanism and Political Theory (Blackwell 2008), Cécile Laborde est l'auteur de Liberalism's Religion (Harvard 2017). Elle est membre de la British Academy et de l'Académie royale de Belgique
A Canonical Form for PROV Documents: Dataset Underpinning Evaluation
No full textDataset supporting:
Luc Moreau (2017) A Canonical Form for PROV Documents and its Application to Equality, Signature, and Validation. ACM Transactions on Internet Technology.
We present a canonical form for PROV that is a normalized way of representing PROV documents as mathematical expressions. As opposed to the normal form specified by the PROV-CONSTRAINTS recommendation, the canonical form we present is defined for all PROV documents, irrespective of their validity, and it can be serialized in a unique way. The paper makes the case for a canonical form for PROV and its potential uses, namely: comparison of PROV documents in different formats, validation, and signature of PROV documents. A signature of a PROV document allows the integrity and the author of provenance to be ascertained; since the signature is based on the canonical form, these checks are not tied to a particular encoding, but can be performed on any representation of PROV.</span
Portrait of the Author in (Him/Her)self
No full textA fragment of a philosophical essay by Jean-Luc Nancy and Federico Ferrari titled Iconographie dell’auteur (Paris, 2005), published for the first time in Polish, that addresses the problem of a relationship between the image of the author and his/her work
UvA-DARE (Digital Academic Repository) HUMU 780 A Single Ser259Arg Mutation in the Gene for Lipoprotein Lipase Causes Chylomicronemia in Moroccans of Berber Ancestry
No full textA single Ser 259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry Foubert, L.; Bruin, T.; de Gennes, J.L.; Ehrenborg, E.; Furioli, J.; Kastelein, J.J.P.; Benlian, P.; Hayden, M.R. Published in: Human Mutation Link to publication Citation for published version (APA): Foubert, L., Bruin, T., de Gennes, J. L., Ehrenborg, E., Furioli, J., Kastelein, J. J. P., ... Hayden, M. R. (1997). A single Ser 259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry. Human Mutation, 10, 179-185. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible
Touching Freud's dog: H.D.'s tactile poetics
No full text"Do not touch me", Frau Emmy warns Freud in 1889. "Do not touch", Freud echoes in 1933. This time, he is referring to his pet chow, Yofi, warning H.D. that "she snaps - she is very difficult with strangers". Examining the prohibition in light of work by Jacques Derrida and Jean-Luc Nancy, this article charts the withdrawal that always interrupts touch. Despite Freud's taboo, however, H.D.'s writing seeks to make contact in strange and unnerving ways. Developing Julia Kristeva's account of the semiotic, this paper proposes a literature of touch. Reading H.D.'s poems, alongside Tribute to Freud, and her letters, the author demonstrates that H.D.'s poetics are always haunted by the very (im)possibility of contact
Provenance-based trust for grid computing: Position Paper
No full textCurrent evolutions of Internet technology such as Web Services, ebXML, peer-to-peer and Grid computing all point to the development of large-scale open networks of diverse computing systems interacting with one another to perform tasks. Grid systems (and Web Services) are exemplary in this respect and are perhaps some of the first large-scale open computing systems to see widespread use - making them an important testing ground for problems in trust management which are likely to arise. From this perspective, today's grid architectures suffer from limitations, such as lack of a mechanism to trace results and lack of infrastructure to build up trust networks. These are important concerns in open grids, in which "community resources" are owned and managed by multiple stakeholders, and are dynamically organised in virtual organisations. Provenance enables users to trace how a particular result has been arrived at by identifying the individual services and the aggregation of services that produced such a particular output. Against this background, we present a research agenda to design, conceive and implement an industrial-strength open provenance architecture for grid systems. We motivate its use with three complex grid applications, namely aerospace engineering, organ transplant management and bioinformatics. Industrial-strength provenance support includes a scalable and secure architecture, an open proposal for standardising the protocols and data structures, a set of tools for configuring and using the provenance architecture, an open source reference implementation, and a deployment and validation in industrial context. The provision of such facilities will enrich grid capabilities by including new functionalities required for solving complex problems such as provenance data to provide complete audit trails of process execution and third-party analysis and auditing. As a result, we anticipate that a larger uptake of grid technology is likely to occur, since unprecedented possibilities will be offered to users and will give them a competitive edge
Implementasi Algoritma LUC Dalam Penyandian Teks
No full textConfidentiality and data security are very important in data communication, both for the purpose of shared security and for individual privacy. Computer users who want the data to be unknown by unauthorized parties always try to get around the way to secure the information that will be communicated or to be stored. One method for securing data or information is cryptographic methods. The LUC algorithm is a cryptographic method using two different keys in the cryptosystem. To encrypt text, an encryption function is used that uses a public key, the result of encryption is encrypted text that is safe from intruders. Furthermore, by decrypting encrypted text using the decryption function using the private key it will return the same text as the original. With the LUC algorithm the author tries to create a text encoding to secure data with the LUC algorithm
Phytochemical, antimicrobial and antiplasmodial investigations on Guinean plant species
No full textAbstract: Medicinal plants have historically proven their value as sources of molecules with therapeutic potential, and nowadays still represent an interesting pool for the discovery of novel drug leads. Current research in drug discovery from medicinal plants involves a multifaceted approach combining several methods and techniques. Despite the considerable progress in terms of research and development of new treatment and prevention procedures over the last decades, infectious diseases still remain the leading cause of death in many developing countries. In Guinea, medicinal plants play an important role in the management of infectious diseases including malaria, urinary disorders, skin diseases and oral diseases. As part of a valorization program of these plant species, ethnopharmacological investigations have been carried out and plants species employed for the treatment of malaria, skin diseases, oral diseases and urinary disorders were inventoried. An extensive bibliographic review, followed by a preliminary biological screening resulted in the selection of some promising plant species including Terminalia albida, Tetracera alnifolia Combretum paniculatum and Pavetta crassipes. In the present research, we propose to deepen the biological and phytochemical investigations on some promising plants extracts, through the evaluation of their potential antimicrobial and antiplasmodial properties, and the corresponding active constituents. The bioassay-guided fractionation of Terminalia albida root resulted in the isolation of 14 compounds (1\u201314), and their antimicrobial properties were evaluated against Plasmodium falciparum, Candida albicans, Staphylococcus aureus and Escherichia coli. Pantolactone (IC50 0.60 \ub1 0.03 ?M) demonstrated significant activity against P. falciparum. Other compounds, including 3,4,3\u2019-tri-O-methyl-ellagic acid, the triterpenes arjunolic acid, arjungenin, arjunic acid and arjunglucoside II, and the phenol glycoside calophymembranside-B, were less active and showed IC50 values in the range 5 \u2013 15 ?M. None of the tested compound showed antibacterial or antifungal activity. Although the n-butanolic fraction was not active, the possibility cannot be excluded that this polar fraction contains inactive glycosides, which may release active aglycones after removal of the glycosidic moieties in the gastrointestinal tract, more in particular in the colon. Therefore, the n-butanolic fraction of the total root extract of Terminalia albida has been subjected to extensive dereplication studies followed by the isolation of the target compounds. As a result, 10 oleanane triterpenoids (1-10), among which six new compounds, i.e. albidanoside A, albidic acid A, albidinolic acid, albidienic acid, albidolic acid, albidiolic acid; two triterpene aglycones, i.e. albidic acid B and albidic acid C isolated here for the first time from a natural source; and two known compounds. Isolated compounds were evaluated for their antiplasmodial and antimicrobial activity against the chloroquine-resistant strain Plasmodium falciparum K1, Candida albicans and Staphylococcus aureus. Compounds 1 - 4, 6 ,7 and 8 demonstrated moderate antiplasmodial activity with IC50 values between 5 and 15 ?M. None of the tested compounds was active against C. albicans or S. aureus. These findings emphasize the potential of T. albida as a source for discovery of new antiplasmodial compounds. The bioassay-guided fractionation of Tetracera alnifolia leaves extracts led to the isolation of 19 compounds (1\u201319). Purification of fractions was performed by flash chromatography, followed by semi-preparative HPLC-DAD-MS and LC-SPE-NMR, while the structural elucidation of the isolated compounds was carried out by 1D and 2D NMR and HR-ESI-MS. Isolated compounds were screened against Plasmodium falciparum, Candida albicans and their cytotoxicity against MRC-5 cells was determined. The highest antiplasmodial activity was obtained for pheophorbide-b methyl ester (1.0 \ub1 0.7 ?M), (1,2)-bis-nor-phytone (2.0 ?M), isophytol (4.0 ?M) , pheophorbide-a methyl ester (2.8 \ub1 1.2 ?M), epicatechin-3-galloylester (5.5 \ub1 2.1), and phytol (6.9 \ub1 2.4 ?M). Other compounds, including myricetin-3-O-rhamnopyranoside, ?-tocopherol and cycloart-24-en-3?-yl ?-linolenate were less active and showed IC50 values in the range 13.5\u2013 25 ?M. None of the tested compounds was active against Candida albicans. A hight cytotoxicity was found for pheophorbide-b methyl ester, pheophorbide-a methyl ester and phytol. Nowadays, the rapid development of modern analytical techniques and various chemometric approaches provide new perspectives for early metabolite identification in natural products research. These techniques represent a potential strategy to streamline the traditional and laborious process of isolating natural products through targeting of unknown active compounds before purification. These innovative techniques have been applied on extracts of the leaves of C. paniculatum, which have demonstrated promising antiplasmodial activity during our preliminary studies, leading to a quick and effective identification of compounds correlated to this activity. The fractionation of crude extracts was carried out, followed by multivariate data analysis of liquid chromatography\u2013high resolution mass spectrometry (LC\u2013HRMS) profiles of the fractions obtained. In parallel, all fractions were screened against Plasmodium falciparum, and their cytotoxicity against MRC-5 cells was determined. Dereplication studies combining UPLC-MS/MS-based molecular networking, in silico analysis and NMR methods were employed to identify the important metabolites. Several compounds strongly correlated with antiplasmodial activity have been highlighted. Six compounds including rutin (IC50 6.7 ?M) and foliasalacioside F (IC50 10.6 ?M ) have been isolated and their OPLS predicted score values were in agreement with antiplasmodial results found in vitro. These preliminary results provided clear evidence on the effectiveness of using these innovative methods (chemometrics and dereplication analysis) for the rapid identification of active metabolites in plant extracts. Further research aiming for the isolating of additional promising compounds which have shown a strong correlation with antiplasmodial activity is ongoing
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